Mostrando ítems 78-97 de 112
Llavanera Bruguera, Marc (Fecha de defensa: 2023-05-12)
Male infertility is a global health problem affecting one in four infertile couples. This also has a negative repercussion on the animal breeding industry, where infertility has a detrimental impact on their balance sheets. ...
Vallverdú Prats, Marta (Fecha de defensa: 2023-02-03)
Arrhythmogenic cardiomyopathy (ACM) is an entity that groups different clinical forms of hereditable cardiac diseases that are associated to ventricular arrhythmia and sudden cardiac death. The main cases are characterized ...
Vert Company, Anna (Fecha de defensa: 2014-07-30)
Cytotoxic ribonucleases are promising agents to be used in the treatment of cancer. Our group previously described a cytotoxic human pancreatic ribonuclease variant, named PE5, which carries a nuclear localization signal. ...
Ferri Iglesias, María José (Fecha de defensa: 2012-09-27)
Serum levels of several molecules associated to pancreatic adenocarcinoma (PDAC) pathophysiology are evaluated in this work, in order to determine their diagnostic value, distinguishing between PDAC patients and healthy ...
Miquel Cusachs, Josep Oriol (Fecha de defensa: 2021-12-17)
The gut microbiota (GM) plays a pivotal role in the maintenance of gut homeostasis, and the pathogenesis of inflammatory bowel disease (IBD) which includes Crohn's disease (CD) and ulcerative colitis (UC). The degree of ...
Yeste Oliveras, Marc (Fecha de defensa: 2008-12-17)
En aquesta tesi s'han dut a terme dos tipus d'estudis diferents. L'objectiu del primer era la preservació del semen de porcí a 15ºC i el del segon eren els co-cultius homòlegs de cèl·lules epitelials de l'oviducte i ...
Duran Sidera, Adrià (Fecha de defensa: 2023-11-14)
Pancreatic cancer (PaC) is the deadliest of all tumours, with a 5-year survival below 12% and a mortality/incidence ratio of 94.5%. One of the main reasons behind this dismal prognosis is the diagnosis of the disease at ...
Chico Julià, Berta (Fecha de defensa: 2009-02-19)
La DM 2 és una malaltia multifactorial i multigènica. Aquest fet condueix a l'estudi de molts gens i proteïnes susceptibles d'estar implicades amb la DM 2. Algunes d'aquestes proteïnes i gens estan associats a un estat ...
Oliveras Ferrarós, Cristina (Fecha de defensa: 2013-06-21)
The aim of this doctoral thesis was to unravel mechanisms underlying primary resistance to trastuzumab regarding a putative new breast cancer subtype with mixed basal & ErbB2+ molecular features. Using the JIMT-1 breast ...
Jurado Bruggeman, Diego (Fecha de defensa: 2023-03-16)
Introduction Different types of dose calculation algorithms for external beam radiation therapy with MV photons coexist nowadays. The oldest ones are convolution/superposition (C/S), which consider all media as water of ...
Mateo Otero, Yentel (Fecha de defensa: 2023-06-13)
For many years, reproductive outcomes were considered as being solely determined by the genome of oocytes and sperm. Yet, in the last decades, many other female and male factors have also been found to be relevant. Focusing ...
Marti Serrano, Elisabet (Fecha de defensa: 2014-03-07)
The overuse of antibiotics has led to the selection of resistant strains. This thesis investigated the occurrence of antibiotic resistance genes (ARGs) in aquatic microbial communities influenced by anthropogenic activities. ...
Balmaña Esteban, Meritxell (Fecha de defensa: 2016-07-07)
Cancer is one of the leading causes of death worldwide. Pancreatic ductal adenocarcinoma (PDAC) is characterized by high intrinsic aggressiveness and late diagnosis, causing poor prognosis and resulting in the lowest ...
Font i Sadurní, Josep (Fecha de defensa: 2006-06-02)
Utilitzant temperatura i pressió com a agents desnaturalitzants s'ha explorat la contribució a l'estabilitat de diferents residus del principal nucli hidrofòbic de la RNasa A. Aquests resutats suggereixen que el principal ...
Fernández Hernández, Maria Victoria (Fecha de defensa: 2012-11-28)
The conservation of species relies on a deep knowledge of biology of the species concerned, as well as on the identification of reproductively isolated units, which are genetically different from one other (genetic stocks). ...
Vicens Bordas, Jordi (Fecha de defensa: 2021-06-16)
The physical demands (high-intensity running and sprinting) of football match-play place footballers at increased risk of hamstring injuries. Some of the negative effects of a hamstring injury such as neuromuscular ...
Delgado Bermúdez, Ariadna (Fecha de defensa: 2022-07-28)
The spermatozoon is a highly specialised cell that travels along the female reproductive tract to deliver its genetic information into the oocyte. During this journey, the interaction with the varying environment is crucial ...
Recuero Cobos, Sandra (Fecha de defensa: 2022-04-01)
In Spain, as well as in the rest of Europe, livestock farming represents a substantial part of economy; thus, it is necessary to ensure an optimal breeding of the main farm animals, including swine and cattle. In order to ...
Gonzalez Montes, Yolanda (Fecha de defensa: 2024-04-12)
Multiple myeloma (MM) remains an incurable disease despite the incorporation of new therapies. The natural history of disease is of the relapse following treatments due to the re-emergence of the tumour from residual disease ...
Coll Constans, M. Gràcia (Fecha de defensa: 2000-03-31)
Bovine pancreatic ribonuclease A (RNase A, EC 3.1.27.5) has been extensively studied from the structural, mechanistic and functional points of view. Within the protein folding context, it constitutes a good ...