Departament de Biologia: Recent submissions
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Estudi comparatiu de la microbiota oral de l'antiga Tàrraco i la població actual
ENG- The present doctoral thesis explores and compares the oral microbiome of ancient dental plaque from burial sites in the ancient Roman city of Tarraco (modern-day Tarragona) with dental plaque from present-day individuals. ...
Fatty acids profile and DNA methylation in the placenta: prevention of cardiometabolic risk and obesity in childhood
ENG- The increase in the prevalence of obesity worldwide over the past 50 years has led to obesity being considered the pandemic of the 21st century. Overweight and obesity are under scrutiny because the current pediatric ...
Patró espacio-temporal de la ligno-suberificació de l’arrel d’Arabidopsis: la funció de les CASPARIAN STRIP MEMBRANE DOMAIN PROTEINS-LIKE en l’endodermis i el fel·lema
ENG- Terrestrial plants develop cellular barriers in stems and roots to protect themselves from adverse environmental conditions. These barriers accumulate lignin and suberin in their walls. Lignin is a polyphenolic polymer ...
Microbiota as indicator of intestinal health and modulation strategies
ENG- Intestinal microbiota, a diverse community of microorganisms residing in the gastrointestinal tract, plays a crucial role in digestion, nutrient absorption, and immune system regulation, thus influencing overall gut ...
Estudi del transcriptoma de l’Escherichia coli adherent-invasiva (AIEC) per desxifrar les bases moleculars implicades en la seva patogenicitat
Adherent-invasive Escherichia coli (AIEC) is a bacterium found in the intestine that can adhere to and invade intestinal epithelial cells and to survive and replicate inside macrophages. Although it has also been detected ...
Altered glycosylation of prostate specific antigen in prostate cancer: structural analysis and assessment for cancer risk stratification
The prostate-specific antigen (PSA) is the reference biomarker for prostate cancer (PCa) diagnosis. This biomarker is increased in PCa, but also in benign prostate hyperplasia (BPH) causing a high number of unnecessary ...
Microbial characterization of different bread-making processes and assessment of their impact on human intestinal dysbiosis and inflammatory bowel disease
Inflammatory bowel disease (IBD) is a group of immune-mediated chronic inflammatory intestinal conditions of multifactorial etiology. Unfortunately, there are still some gaps in its pathophysiology and, therefore, in its ...
Polimorfismos de los genes moduladores de la respuesta inmune como predictores de recaída en los pacientes con mieloma múltiple
Multiple myeloma (MM) remains an incurable disease despite the incorporation of new therapies. The natural history of disease is of the relapse following treatments due to the re-emergence of the tumour from residual disease ...
New tumour markers for pancreatic cancer based on the altered glycosylation of serum glycoproteins
Pancreatic cancer (PaC) is the deadliest of all tumours, with a 5-year survival below 12% and a mortality/incidence ratio of 94.5%. One of the main reasons behind this dismal prognosis is the diagnosis of the disease at ...
Relevance of sperm chromatin protamination, condensation and DNA integrity for sperm function and fertility: the role of toroid linker regions
Male fertilising capacity has traditionally been predicted by the assessment of sperm concentration, motility and morphology. During the last few decades, however, research has been particularly focused on the analysis of ...
Relació de la proteïna C-reactiva, el quocient neutròfils/limfòcits i l’adiponectina d’alt pes molecular amb paràmetres d’obesitat i de risc cardiometabòlic en nens prepuberals sans. Efecte modulador dels estils de vida
Childhood obesity is one of the most important public health problems and is associated with cardiometabolic risk factors (CMR). Low-grade inflammation plays a prominent role in the development of cardiometabolic alterations ...
L’extracte de fulla d’olivera redueix la pressió arterial de pacients amb hipertensió arterial lleugera sense malaltia vascular subclínica
Introduction: Hypertension is the common cardiovascular risk factor and affects 20 to 50% of the population. Treatment, with drugs or not, involves improving lifestyle. Olive leaf extract has traditionally been taken to ...
Variability in the health status and reproductive traits of European sardine stocks in the Mediterranean. Implications for fishery management
Small pelagic fish play an important ecological role mainly due to their contribution in transferring energy from low to higher trophic levels. Likewise, the capture of these species is in many cases an important nutritional ...
Molecular insights into mammalian sperm physiology: a comparative study of glutathione S-transferases in male reproduction
Male infertility is a global health problem affecting one in four infertile couples. This also has a negative repercussion on the animal breeding industry, where infertility has a detrimental impact on their balance sheets. ...
Novel insights into paternal factors influencing the maternal environment and embryo development
For many years, reproductive outcomes were considered as being solely determined by the genome of oocytes and sperm. Yet, in the last decades, many other female and male factors have also been found to be relevant. Focusing ...
Nova metodologia d’anàlisi de distribucions de dosi per algorismes de càlcul de dosi absorbida en radioteràpia externa que simulen el transport de radiació en medi
Introduction Different types of dose calculation algorithms for external beam radiation therapy with MV photons coexist nowadays. The oldest ones are convolution/superposition (C/S), which consider all media as water of ...
Dehiscencia de anastomosis en la cirugía del cáncer de recto: incidencia, factores pronósticos y morbimortalidad asociada
Introduction: Anastomotic leak (AL) is the most feared complication in the postoperative period for patients with rectal cancer. Objectives: To determine the real rate of AL in patients operated on for rectal cancer. ...
Factors pronòstics en la dehiscència anastomòtica de la cirurgia del càncer de còlon. Models de predicció actuals i validació externa independent
INTRODUCTION: Anastomotic leak (AL) is the most dreadful and life-threatening complication in colon cancer (CC) surgery. It is associated to an increase of morbimortality, longer hospital stay, increased healthcare costs ...
Molecular insights on arrhythmogenic cardiomyopathy: assessment of premature termination codons in desmosomal genes and variants reclassification
Arrhythmogenic cardiomyopathy (ACM) is an entity that groups different clinical forms of hereditable cardiac diseases that are associated to ventricular arrhythmia and sudden cardiac death. The main cases are characterized ...
Inhibition of sialyltransferases in pancreatic cancer: effects on the EGFR pathway and on the tumour phenotype
Pancreatic ductal adenocarcinoma (PDA) presents a dismal prognosis mainly due to its delayed diagnosis, its aggressiveness, and resistance to existing therapies. Aberrant glycosylation and, in particular, the overexpression ...
