Universitat de Barcelona
Mostrando ítems 1-19 de 19
El sistema de complemento es parte fundamental de la inmunidad innata, actúa reconociendo patrones moleculares asociados a microorganismos y patógenos, provenientes de ambiente extracelular. Su función principal es la ...
Esta tesis es el resultado de un proyecto multicéntrico y traslacional en pacientes pediátricos con trastornos del movimiento y alteraciones en los ganglios basales, centrándose en la parte bioquímica y genética desde un ...
[eng] Neuroblastoma (NB) is the most common extracranial solid childhood tumour. Its clinical and histological manifestations range from benign tumours that spontaneously regress to highly aggressive metastatic tumours ...
This thesis is a study on the integrin-mediated mechanoresponse by binding partners and force loading rates. Regarding the binding partners, here we demonstrate an alternative and counter-intuitive mechanism, by which ...
En esta tesis se estudian dos aspectos, el desarrollo de herramientas diagnósticas y terapéuticas aplicado a dos enfermedades metabólicas hereditarias: la deficiencia del transportador de creatina (CRTR) y la enfermedad ...
Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia in Western countries. Although the disease might follow an indolent course, it rapidly progresses in a fraction of cases, become resistant to ...
La regulación y potenciación de la proliferación de la célula β pancreática es un objetivo principal en la prevención y/o retardo de la diabetes. Su replicación se regula a través de un proceso dinámico, siendo muy elevada ...
La ICSI és una tècnica de reproducció assistida molt eficient, però la fallada de fecundació (FF) pot ocórrer en un 1-3% dels cicles. La FF té un elevat impacte en els pacients i és molt difícil de predir, diagnosticar i ...
[cat] El glioblastoma (GBM) és el tumor primari cerebral més freqüent i més agressiu. Els pacients amb GBM tenen una supervivència mitjana de 15 mesos. Una dels principals dificultats que presenten els GBMs per ser tractats ...
Hepatocellular Carcinoma (HCC) is one of the most common cancers. During hepatocarcinogenesis (a multistep process) there is a disruption of the balance between cell death and survival signalling pathways, where pro-apoptotic ...
La apoptosis es un proceso biológico fuertemente conservado a lo largo de la evolución que consta de un sistema de regulación complejo en el que intervienen gran cantidad de proteínas, en su mayoría relacionadas con la ...
La malaltia hepàtica per consum d'alcohol és una hepatopatia crònica amb alta taxa de mortalitat. Aquests pacients poden presentar episodis d'hepatitis alcohòlica (HA), caracteritzats histològicament per dany hepatocel·lular, ...
Ewing sarcoma (ES) is a highly aggressive tumour of the bone and soft tissue that typically affects children, adolescents, and young adults. The fusion protein EWSR1‐FLI1 is the main genetic alteration found that acts as ...
[ENG] CK2 is a constitutively active serine/threonine kinase that consists in a tetramer composed by two catalytic and two regulatory subunits (termed Cka1, Cka2, Ckb1 and Ckb2 in yeast, respectively). Catalytic subunits ...
One of the main causal factors of skin aging is ultraviolet radiation as part of sun exposure. This radiation induces many changes at the molecular level that alter the proper function of skin biological processes, being ...
[eng] The arrival of antiangiogenic therapies represented a huge advance in the treatment of different tumors, such as renal carcinoma. However, despite initial good results, some tumors were able to develop different ...
ZEB1 is a transcription factor best known for its role in cancer progression and metastasis. It is also expressed during embryonic development of different tissues although its function and mechanism of action have not ...
The members of ZEB family of transcription factors (ZEB1 and ZEB2) are widely known for its role in epithelial-to-mesenchymal transition (EMT), a highly relevant process during development and tumor progression. In this ...
The DNA from our cells carries the genetic information to build a human being. This information is interpreted through epigenetic marks that lead to tightly coordinated and cell type-specific gene expression programs. One ...
