Cognitive function in obesity: interactions with the gut microbiome 

    Arnoriaga Rodríguez, María (Date of defense: 2022-04-27)

    Obesity is considered a modifiable risk factor for cognitive impairment which, in turn, predisposes to overeating and weight gain. Compelling evidence in animal models has demonstrated the impact of the gut microbiome on ...

    Determinació del patró de miRNA en líquid cefaloraquidi de pacients amb esclerosi múltiple (estudi miEM) 

    Ramió i Torrentà, Lluís (Date of defense: 2014-10-23)

    Multiple sclerosis is a chronic neurological disease of the central nervous system with unknown, autoimmune mechanism, and a progressive and disabling course. Lipid-specific oligoclonal IgM bands in cerebrospinal fluid ...

    Grape stalk and coffee polyphenolic extracts administration as new pharmacological strategies to modulate spinal cord injury-induced neuropathic pain in mice 

    Bagó Mas, Anna (Date of defense: 2022-03-18)

    More than half of spinal cord injury patients develop central neuropathic pain, which is largely refractory to current treatments. Developing neuropathic pain has a high impact on the quality of life becoming an emotional, ...

    Identificación de genes de susceptibilidad en esclerosis múltiple. Descripción clínica y análisis genético de una extensa familia de etnia gitana (Estudio EMGypsy) 

    Robles Cedeño, René (Date of defense: 2016-07-19)

    Multiple sclerosis is a chronic disease of the central nervous system which has an unknown aetiology and an autoimmune mechanism. Two pathogenic processes, inflammation and neurodegeneration, converge causing a progressive ...

    La relación beneficio-riesgo del tratamiento farmacológico para la enfermedad de Alzheimer 

    Blanco Silvente, Lídia (Date of defense: 2019-07-08)

    The evidence available in the medical literature is conclusive that the risk-benefit relationship of the current medications for Alzheimer's disease is not favourable. This risk-benefit relationship is not significantly ...

    Methylome profiling of B and T cells along multiple sclerosis disease progression: a pilot study 

    Celarain Sanz, Naiara (Date of defense: 2023-06-26)

    Multiple sclerosis (MS) is a chronic, inflammatory, autoimmune and neurodegenerative disease characterized by the infiltration of autoreactive immune cells into the central nervous system that leads to axonal damage, ...

    El nivell i la variació del risc cardiovascular en la prevenció primària de la demència 

    Fages Masmiquel, Ester (Date of defense: 2023-09-14)

    Dementia causes progressive cognitive impairment and inability to lead an independent life. Currently, there is no curative treatment for it, and thus primary prevention is essential. Age is the main risk factor for ...

    Nou mecanismes implicats en els dèficits transcripcionals i la pèrdua del BDNF en la malaltia de Huntington: descripció de noves dianes terapèutiques 

    Vidal Sancho, Laura (Date of defense: 2018-01-10)

    Huntington disease is a neurodegenerative disorder characterized by motor, cognitive and psychiatric dysfunction. Huntington disease is caused by an expanded CAG trinucleotide repeat at the exon 1 of the IT15 gen, which ...

    Nuevos determinantes moleculares en la respuesta a isquemia cerebral 

    Gubern Mérida, M. Carme (Date of defense: 2015-12-18)

    Cerebral ischaemia is a potent inducer of gene expression, however, little is known about the mechanisms that regulate this expression. Studies of gene expression and the study of the mechanisms regulating this expression ...

    Papel del diffusion tensor imaging en la resonancia magnética cerebral como marcador predictivo del estado motor y evolución funcional en pacientes con hemorragia intracerebral 

    Terceño Izaga, Mikel (Date of defense: 2018-02-06)

    The present thesis, aims to study whether the evaluation of the CT through DTI and tractography sequences in the first 12 hours from the ICH onset, is able to predict the motor and functional outcome at 3 months. The ...

    Projecte EM-Line!: programa de rehabilitación cognitiva para pacientes afectados de esclerosis múltiple 

    Gich Fullà, Jordi (Date of defense: 2013-07-18)

    The clinical manifestations of Multiple Sclerosis are motor, sensitive, cerebellar and cognitive alterations. It evolves with a high degree of physical and cognitive disability. The “EM-line! Project” has its origins in ...

    Role of miRNAs in multiple sclerosis: study of miRNAs in cerebrospinal fluid for different clinical conditions 

    Muñoz San Martín, María (Date of defense: 2021-09-15)

    Multiple sclerosis (MS) is considered a chronic inflammatory and neurodegenerative disease, characterized by the existence of demyelinated areas in the central nervous system, infiltration of inflammatory cells in the ...

    Study of two analogues of pituitary adenylate cyclase-activating polypeptide as novel therapeutic compounds for Huntington’s disease 

    Solés Tarrés, Irene (Date of defense: 2023-06-14)

    Huntington’s disease (HD) is a neurodegenerative genetic disorder with no effective treatment characterized by motor discoordination, deficits in cognitive function (acquiring new knowledges, memory, understanding…), and ...

    Therapeutic potential of pituitary adenylate cyclase-activating polypeptide and epigallocatechin gallate in motor and cognitive deficits of Huntington's disease models 

    Cabezas Llobet, Núria (Date of defense: 2019-02-28)

    Huntington's disease (MH) is a progressive neurodegenerative disorder characterized by a motor dysfunction, cognitive impairment, and psychiatric symptoms. At neuropathological level, it has been described that cognitive ...