Departament de Ciències Mèdiques: Recent submissions
Now showing items 61-80 of 102
DNA methylome in HER2-positive resistant breast cancer
The major clinical problem for HER2+ breast cancer target therapies is the acquisition of resistance. The DNA methylation status of the promoter gene region has been described as a common epigenetic alteration for ...
Influencia de la grasa epicárdica en la arritmia: fibrilación auricular, la cardioversión eléctrica, la recurrencia y el tratamiento
The thickness of epicartic fat can be directly measured by transthoracic echocardiography. Epicartic fat has recently been associated with the onset of atrial fibrillation (AF). In this work we will analyze the relationship ...
Therapeutic potential of pituitary adenylate cyclase-activating polypeptide and epigallocatechin gallate in motor and cognitive deficits of Huntington's disease models
Huntington's disease (MH) is a progressive neurodegenerative disorder characterized by a motor dysfunction, cognitive impairment, and psychiatric symptoms. At neuropathological level, it has been described that cognitive ...
Muerte súbita natural inexplicada: valor de la investigación genética post mortem
Natural death defines the death primarily attributed to an illness or an internal malfunction of the body, and not directly influenced by external forces. Most causes can be identified directly with macroscopic forensic ...
Regulome-seq: a novel approach for the identification of non-coding variants associated with human disease. Assessment of its applicability in 89 Brugada syndrome individuals
Brugada syndrome (BrS) is a cardiac electrical disease with high susceptibility to sudden cardiac death. Approximately 25-30% of BrS patients are explained by pathogenic variants in coding sequences of cardiac ion channels, ...
Factors associated with arterial stiffness in a general Mediterranean population and in a Mediterranean intermediate cardiovascular risk population
The objectives of the thesis are to estimate the prevalence of pathological arterial stiffness (measured with the Cardio-Ankle Vascular Index –CAVI-) in a general Mediterranean population and in a Mediterranean intermediate ...
Factors associats a la incidència de fibril·lació auricular i estudi de l'associació del tractament amb estatines amb la incidència d'aquesta arítmia en població hipertensa sense antecedents de malaltia isquèmica vascular
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and implies a huge social, medical, and economical burden. Analyses of AF risk factors in certain groups of population would allow tailored ...
WNT5A, SFRP5 y CRTC3: nuevas adipocinas relacionadas con la obesidad en la edad pediátrica
WNT5A is a protein with proinflammatory properties recently related to insulin resistance. It is believed that this protein might be regulated by SFRP5, which sequesters WNT5A exerting its anti-inflammatory actions and ...
Bypass gástrico en el tratamiento de la obesidad mórbida. Seguimiento a 5 años de los primeros 300 casos en la provincia de Girona
A prospective study on 300 morbidly obese patients who underwent gastric bypass in the province of Girona with a follow-up of 5 years.More female (288/12), mean age 43.5 years, mean weight 118.7 kg, mean BMI 46.1 kg/m2. ...
Nou mecanismes implicats en els dèficits transcripcionals i la pèrdua del BDNF en la malaltia de Huntington: descripció de noves dianes terapèutiques
Huntington disease is a neurodegenerative disorder characterized by motor, cognitive and psychiatric dysfunction. Huntington disease is caused by an expanded CAG trinucleotide repeat at the exon 1 of the IT15 gen, which ...
Sistema immunitari i marcadors de risc cardiometabòlic en l'edat pediàtrica
We studied the relationship between the circulating levels of the innate immune system molecules (α-defensins and BPI) and the acquired immune system (IgG, IgA and IgM) with obesity and cardiometabolic risk factors in ...
Papel del diffusion tensor imaging en la resonancia magnética cerebral como marcador predictivo del estado motor y evolución funcional en pacientes con hemorragia intracerebral
The present thesis, aims to study whether the evaluation of the CT through DTI and tractography sequences in the first 12 hours from the ICH onset, is able to predict the motor and functional outcome at 3 months. The ...
Arteopatia perifèrica i factors de risc cardiovascular. Millora de la prevenció secundària dels pacients amb arteriopatia perifèrica en l'atenció primària
Cardiovascular risk factors control is low in peripheral artery disease patients. Leukocyte count over7.8 K/mcL or neutrophil count over 4.6 K/mcL are predictors of increased risk for heart coronary disease, cerebral ...
Detecció de Copy Number Variants mitjançant seqüenciació d'alt rendiment en la Mort Sobtada Cardíaca hereditària
Arrhythmogenic cardiac diseases are the main cause of SCD among the population under 35 years of age. Despite the improvements in genetic diagnosis, the percentage of cases that remain unexplained after genetic analysis ...
Identificació de microRNAs circulants i placentaris en obesitat materna gestacional i la seva relació amb paràmetres metabòlics materns i el creixement pre i postnatal
Increased metabolic disease in children is a major public health problem.. Epigenetic marks, such as microRNAs, could be one of the mechanisms that regulate the association maternal obesity with the development of metabolic ...
Arteriopatia perifèrica assimptomàtica: prevalença, detecció i tractament
Background There is few epidemiological data of peripheral arterial disease (PAD) in our environment. The recommendation of screening with ankle brachial index (ABI) in asymptomatic individuals is controversial. Evidence ...
Relación entre el flujo de la arteria cerebral media y la presión en la arteria carótida interna durante la endarterectomía carotídea
Risk of cerebral hypoperfusion during carotid endarterectomy arterial is the main limiting factor of this technique. Shunt allows partial maintenance of cerebral perfusion during clamping. We analyze the hemodynamic ...
Determinants moleculars de la mort sobtada cardíaca en una gran família de les Illes Canàries
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a sudden cardiac death (SCD) associated disease characterized by the presence of polymorphic or bidirectional ventricular tachycardia during emotional or ...
Eficàcia, seguretat i abandonament del tractament farmacològic del trastorn per dèficit d’atenció amb hiperactivitat en pacients adults
There are concerns about the benefit-risk ratio of pharmacologic interventions for ADHD in adults, especially in patients with ADHD and substance use disorder (SUD). Four systematic reviews of randomized placebo-controlled ...
Els factors GATA4 i GATA5 en la regulació transcripcional del gen que codifica pel canal de sodi cardíac (SCN5A)
The SCN5A gene encodes the alpha subunit of the cardiac sodium channel (NaV1.5), which is responsible for the influx of sodium ions through membrane of cardiomyocytes. Different evidences suggest that an aberrant expression ...
