Mostrando ítems 229-234 de 234
Moles Fernández, Alejandro (Fecha de defensa: 2022-01-31)
Patients with hereditary breast and ovarian cancer (HBOC) in whom a causative pathogenic variant is not identified after genetic analysis may not benefit from prevention, early detection, or precision treatment measures. ...
Azagra Rodríguez, Alba (Fecha de defensa: 2019-11-29)
B lymphopoiesis is the result of several cell lineage choices and differentiation steps whose perturbation leads to B cell malignancies. Cellular transitions for B cell generation have been associated with gene activation ...
Giroud-Gernetant Deus, Judith (Fecha de defensa: 2023-11-20)
[eng] Lysinuric Protein Intolerance (LPI) is a rare autosomal recessive disorder caused by mutations in the SLC7A7 gene, which encodes the y+LAT1 transporter. LPI presents a pleiotropic phenotype that varies among patients, ...
Pérez Albaladejo, Elisabet (Fecha de defensa: 2017-09-18)
En esta tesis se investiga la utilidad de diferentes bioensayos basados en el uso de líneas celulares (peces/humanas) y fracciones subcelulares, para la caracterización del riesgo ambiental que diversos contaminantes ...
Salvadores Ferreiro, Marina (Fecha de defensa: 2024-01-18)
[eng] Mutations exhibit an uneven distribution across the human genome, with a regional mutation density (RMD) influenced by chromatin landscapes and replication timing. While there is a good understanding of this variation, ...
Ramos Rodríguez, Mireia (Fecha de defensa: 2020-11-06)
Type 1 Diabetes (T1D) is a celltargeted autoimmune disease, leading to a reduction in pancreatic cell mass that renders patients insulindependent for life. In early stages of the disease, cells from the immune system ...