Now showing items 222-229 of 229
Menéndez Serra, Mateu (Date of defense: 2022-06-16)
Understanding the mechanisms and processes driving biological com- munities assembly, i.e. determining why a specific community is found under certain circumstances, is one of the fundamental questions in ecology. The ...
Buitrago Ospina, Diana Camila (Date of defense: 2019-12-16)
Understanding the connection between DNA organization in the nucleus, and cell functioning is one of the most intriguing problems in biology. Although many interdisciplinary efforts have been developed for this aim, the ...
Moles Fernández, Alejandro (Date of defense: 2022-01-31)
Patients with hereditary breast and ovarian cancer (HBOC) in whom a causative pathogenic variant is not identified after genetic analysis may not benefit from prevention, early detection, or precision treatment measures. ...
Azagra Rodríguez, Alba (Date of defense: 2019-11-29)
B lymphopoiesis is the result of several cell lineage choices and differentiation steps whose perturbation leads to B cell malignancies. Cellular transitions for B cell generation have been associated with gene activation ...
Giroud-Gernetant Deus, Judith (Date of defense: 2023-11-20)
[eng] Lysinuric Protein Intolerance (LPI) is a rare autosomal recessive disorder caused by mutations in the SLC7A7 gene, which encodes the y+LAT1 transporter. LPI presents a pleiotropic phenotype that varies among patients, ...
Pérez Albaladejo, Elisabet (Date of defense: 2017-09-18)
En esta tesis se investiga la utilidad de diferentes bioensayos basados en el uso de líneas celulares (peces/humanas) y fracciones subcelulares, para la caracterización del riesgo ambiental que diversos contaminantes ...
Salvadores Ferreiro, Marina (Date of defense: 2024-01-18)
[eng] Mutations exhibit an uneven distribution across the human genome, with a regional mutation density (RMD) influenced by chromatin landscapes and replication timing. While there is a good understanding of this variation, ...
Ramos Rodríguez, Mireia (Date of defense: 2020-11-06)
Type 1 Diabetes (T1D) is a celltargeted autoimmune disease, leading to a reduction in pancreatic cell mass that renders patients insulindependent for life. In early stages of the disease, cells from the immune system ...