Now showing items 26-45 of 234
Buira Morell, Irma (Date of defense: 2011-02-04)
L’insomni és un trastorn caracteritzat per la insatisfacció en la qualitat i/o quantitat del son, que persisteix durant un considerable període de temps. És un son no reparador, amb conseqüències diürnes com la fatiga, la ...
Lledós i de Benito, Miquel (Date of defense: 2024-03-15)
[spa] Esta tesis investiga la asociación de la microbiota intestinal con el ictus isquémico. Se reclutaron un total de 340 pacientes con ictus, de los cuales se analizó una muestra fecal para obtener un perfil taxonómico ...
Arranz Villacañas, Juan (Date of defense: 2016-12-16)
DYRK1A es un gen del cromosoma 21 humano que codifica para una proteína quinasa constitutivamente activa que fosforila a sustratos que son clave en el desarrollo del cerebro. La proteína DYRK1A regula el crecimiento del ...
Hardy-Werbin, Max (Date of defense: 2020-01-30)
El cáncer de pulmón de célula pequeña (CPCP) es el subtipo mas agresivo del cáncer de pulmón. Mas de la mitad de los pacientes se diagnostican con enfermedad diseminada, donde el tratamiento de elección desde la década de ...
Torrealba Sandoval, Débora Alejandra (Date of defense: 2016-06-03)
El mantenimiento de la homeostasis del sistema inmune innato es fundamental, ya que éste debe mantener una respuesta equilibrada frente a los patógenos. En mamíferos, uno de los mecanismos por el cual se mantiene la ...
Bellido Molías, Fernando (Date of defense: 2015-07-17)
La presente tesis doctoral consta de 4 proyectos independientes centrados en el estudio de las causas genéticas del cáncer colorrectal (CCR) hereditario: A) Estudio de una variante común (rs2075786) en el gen de la ...
Meléndez Esteban, Elena (Date of defense: 2022-03-24)
The ectopic expression of transcription factors Oct4, Sox2, Klf4 and Myc (OSKM) enables the conversion of differentiated cells into pluripotent stem cells, a process known as “reprogramming”. Methods based on in vivo ...
Marin Guillen, Ines (Date of defense: 2023-04-20)
[eng] Cellular senescence is a response to stress and damage, ant it is known to activate innate immune cells. However, the mechanisms by which senescent cells interact with the adaptive arm of the immune system and their ...
Boada Garcia, Jordi (Date of defense: 2016-04-22)
Macrophyte systems are globally vulnerable to overgrazing, often shifting precipitously to functionally poorer alternative stable states triggered by herbivore population outbreaks. Sea urchin herbivory can cause shifts ...
Mendoza Blanco, Mónica (Date of defense: 2023-11-24)
[eng] Neurons are highly polarized cells that require protein synthesis in distal dendrites to fulfil local protein requirements on short timescales. The regulation of this process relies in two major sub processes: the ...
Vicioso Mantis, Marta (Date of defense: 2022-09-27)
The thesis objectives resulted from previous work from Dr Martínez-Balbás lab that characterized the cooperation between TGFβ and JMJD3 to regulate transcription at enhancers, promoters, and gene bodies.Taking into ...
Aseeri, Mazen (Date of defense: 2023-03-13)
[eng] The main goals of this PhD thesis are closely related within the field of CDases and their key role in the regulation of sphingolipid metabolism. Thus, the roles of ACER3 and AC in different human diseases are of ...
Puiggros Metje, Anna M. (Date of defense: 2015-07-10)
Un dels factors pronòstics més importants en la leucèmia limfàtica crònica (LLC) són les categories de risc citogenètic, basades en la detecció de del(13q), trisomia 12, del(11q) i del(17p) per hibridació in situ fluorescent ...
Schikora Tamarit, Miquel Àngel (Date of defense: 2023-11-03)
[eng] Fungal infections pose a serious health threat, affecting >1,000 million people and causing ~1.5 million deaths each year. The problem is growing due to insufficient diagnostic and therapeutic options, increased ...
Cañete Ríos, Manuel (Date of defense: 2020-11-27)
Xenopus laevis oocytes are transcriptionally silent cells that require hormone stimulation for maturing into fecundation-competent eggs. Meiosis resumption underlying oocyte maturation is governed by sequential waves of ...
Ruiz Cánovas, Eugenia (Date of defense: 2018-12-10)
Compound F has been reported to possess important antioxidant, anti-inflammatory, anti- diabetic and anti-cancer effects, among other interesting properties. Although Compound F has been extensively investigated, its ...
Xiol Viñas, Clara (Date of defense: 2023-12-22)
[eng] Rett syndrome (RTT) is a severe neurodevelopmental disorder characterized by a regression in acquired skills, such as purposeful hand use and language, after an apparently normal early development. RTT affects ...
Valls Margarit, Jordi (Date of defense: 2021-06-08)
One of the central aims of biology and biomedicine has been the characterisation and understanding of genetic variation across humans, to answer important evolutionary questions and to explain phenotypic variability ...
Lema Amado, Rafael (Date of defense: 2020-11-19)
The connection between DNA folding and chromatin conformation has been much studied but the relation between the modulation of chromatin conformation and biological processes such as DNA damage, cell differentiation and ...
Llorens Marès, Tomàs (Date of defense: 2015-07-28)
The main objective of this PhD dissertation was to unveil the links between biogeochemistry and microbial diversity using metagenomics functional potential as a proxy to connect a mechanistic perspective with whole-system ...