Now showing items 95-114 of 234
González Nieto, Jèssica (Date of defense: 2021-03-23)
La cromatina és una estructura nucleoproteïca dinàmica i jeràrquicament organitzada dins del nucli cel·lular. Segons la seva funcionalitat, la cromatina es pot classificar en dos tipus de regions: l’eucromatina, també ...
Alibakhshi, Esmaeil (Date of defense: 2019-12-13)
INTRODUCTION: Patients with chronic respiratory disease (CRDs) have a disorder in muscle structure and function, but their function increases with physical progress and decreases the risk of general and muscular weakness. ...
Franco Valls, Héctor (Date of defense: 2022-05-26)
SNAIL1 is a transcription factor with roles in repression of epithelial genes and enhancement of mesenchymal genes. As such, it plays a key role in Epithelial-to-mesenchymal transition and in fibroblast activation into ...
Carvalho Simoes, Francisco Manuel de (Date of defense: 2018-07-06)
Glucose transporters (GLUTs) are extremely important for glucose metabolism. Glucose transporters uptake glucose from blood stream into the cells where it can be metabolized. Among the glucose transporters family, GLUT4, ...
Alonso Parrilla, Lorena (Date of defense: 2023-01-16)
[eng] One of the major and most challenging goals of Biomedicine during the last centuries has been the study of the human biological mechanisms, and its relation with traits and diseases. Particularly, in the case of ...
Iacobucci, Simona (Date of defense: 2021-03-18)
Taking into consideration the current knowledge about the subjects treated, several goals were proposed for this PhD thesis in order to further understand PHF8 function in both astrocytes and neural stem cells biology. To ...
López Ferrando, Víctor (Date of defense: 2019-12-11)
Single amino acid variants (SAVs) are one of the main causes of Mendelian disorders, and play an important role in the development of many complex diseases. At the same time, they are the most common kind of variation ...
Llorente Lope, Alicia (Date of defense: 2021-03-23)
Metastatic breast cancer (BCa) is the leading cause of death in BCa patients. Current therapies for BCa aim at cell proliferation and, therefore, latent disseminated cells are able to escape treatment. For this reason, ...
Norris, Richard (Date of defense: 2021-10-13)
Insulinomas are extremely rare pancreatic neuroendocrine (PNET) tumours that develop from the β-cells of the pancreas.β-cells are the only cells capable of producing the hormine insulin, and play a major role in glucose ...
Serra Vinardell, Jenny (Date of defense: 2015-09-18)
La malaltia de Gaucher (GD) forma part d'un conjunt de malalties que es coneixen amb el nom de "malalties d'acumulació lisosómica". La GD n'és la més prevalent i en la majoria de casos és causada per mutacions en el gen ...
Matas Gironella, Júlia (Date of defense: 2021-12-20)
Colorectal cancer (CRC) is a major health burden with large numbers of new cases worldwide and high disease-specific mortality, despite great advances made towards improving patient clinical outcomes. It arises through the ...
Rojas Salarich, Itziar de (Date of defense: 2023-07-05)
[eng] Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Research in the past decade has led to major progress in understanding the genetic etiology of the disease; since I started my PhD (2019), nearly ...
Vilar Ribó, Laura (Date of defense: 2023-11-20)
[eng] Substance use disorders (SUDs) are psychiatric disorders characterized by a recurring desire to continue taking a substance regardless of its destructive consequences. The etiology of SUDs is complex and multifactorial, ...
Aguado Flor, Ester (Date of defense: 2024-04-12)
[eng] During radiotherapy (RT) some healthy tissues are irradiated inevitably causing side effects, without being able to predict nowadays which patients will develop this toxicity. To date, the biomarker with the best ...
Turón Rodrigo, Gemma (Date of defense: 2019-04-25)
Colorectal tumors are not homogeneous entities but rather composed of a mixture of cells with different phenotypes, reminiscent of healthy intestinal epithelium cell types. Intestinal epithelium is one of the organs with ...
Casso Carrasco, Maria (Date of defense: 2020-03-12)
Invasive species constitute a major threat to global biodiversity and cause important economic losses and ecological impacts. In the marine realm, ascidians include several aggressive invasive species, some of which have ...
Garate Amenabarro, Leyre (Date of defense: 2017-09-01)
El estudio se centra la filogenia, biología y ecología de la demosponja Hemimycale columella y su simbiosis con una bacteria calcificadora (calcibacteria). Posteriormente se incorporaron otras especies para entender tanto ...
Muñiz Pérez, Diana (Date of defense: 2013-10-29)
Los hongos calicioides es un grupo artificial de hongos, liquenizados y no-liquenizados, que se incluían dentro del antiguo orden Caliciales, y que ahora se mantienen agrupados debido la similar morfología de sus apotecios ...
Janatian, Nasime (Date of defense: 2021-08-27)
In the present thesis we focus on the two extremes of the wind speed – storms and atmospheric stilling – and analyse their impacts on lake environments and phytoplankton dynamics over short and long periods. As we realised ...
Castillo Díez, Sandra (Date of defense: 2011-11-09)
El análisis de la expresión global y de número de copias de DNA en tumores primarios y líneas celulares de cáncer de pulmón reveló la presencia de amplificación génica en los cromosomas 11q12, 13q34 y 6p22. En los cromosomas ...