Universitat de Barcelona
Now showing items 41-59 of 59
Classical force fields are the core of classical simulations, particularly of molecular dynamics (MD), a technique that is changing our view on the structure, flexibility and function of biological macromolecules. Originated ...
Las proteínas insulator son componentes esenciales de la organización tridimensional de la cromatina ya que son capaces de establecer interacciones entre regiones distantes de la mediante su capacidad de asociarse a otras ...
Modern lifestyles in an increasing number of human societies include consuming an excess of saturated fats and refined sugars as well as enjoying microbiologically aseptic environments. Maintaining the appropriate ...
[eng] DYRK1A is a kinase that is expressed in virtually all tissues and cell types and is implicated in human diseases. Several studies indicate that DYRK1A is a dose-dependent gene with a prevalent function in brain ...
[eng] The lungs are constantly exposed to external particles and microbes, so their particular immune environment is immunosuppressive to avoid unnecessary inflammatory responses. This increases the susceptibility of this ...
Tumors evolve by sequentially acquiring genetic abnormalities, like K-Ras activation and Tp53 loss of function, which enable transformed cells to survive, proliferate, invade, and reprogram their microenvironment. ...
The regulated secretory pathway is a hallmark of professional secretory cells as neurons and endocrine cells. Significant peptidergic neurotransmitters as hormones, neurotrophins and growth factors are targeted to ...
Cell fate is controlled by a multitude of signals and loss of this control has devastating consequences for living organisms. One of the key players in this network of signals is the TGF-beta family of cytokines. These ...
Body axis elongation is a hallmark of the vertebrate embryo, which also comprises the morphogenesis of the caudal neural tube (NT). The contribution of bipotential neuromesodermal progenitors (NMPs) to the cranio-caudal ...
Genome-wide association studies (GWAS) have been proven useful for identifying thousands of associations between genetic variants and human complex diseases and traits. However, the identified loci account for a small ...
[eng] The histone H1 family comprises up to seven members in human somatic cells. However, H1 studies have been limited by the lack of specific ChIP-grade antibodies. Here, we have mapped six endogenous H1 variants in T47D ...
Microtubules (MTs) mediate a range of essential cellular processes including cell division, intracellular transport and organelle positioning, by forming specifically adapted arrays. Assembly, maintenance and remodelling ...
The Sirtuin family of NAD+-dependent enzymes plays a key role in the maintenance of genome integrity upon stress. Sirtuins coordinate the response to different forms of stress at different levels and have been involved ...
Monoamine Neurotransmitter diseases are a rare group of inherited disorders of metabolism that encompass 12 different genetic defects leading to abnormal dopamine and/or serotonin brain homeostasis. They correspond to ...
Trastuzumab-emtansine (T-DM1) is an antibody-cytotoxic agent (DM1) conjugated drug. DM1 delivery by trastuzumab inside the HER2 positive cells affects microtubule polymerization, cell cycle arrest and finally cell death. ...
[eng] For this purpose, Spatial Analysis of Functional Enrichment (SAFE) framework was proposed to uncover functional regions in a network by embedding it in 2-dimensions (2D) using the Spring embedding algorithm. However, ...
Understanding the connection between DNA organization in the nucleus, and cell functioning is one of the most intriguing problems in biology. Although many interdisciplinary efforts have been developed for this aim, the ...
B lymphopoiesis is the result of several cell lineage choices and differentiation steps whose perturbation leads to B cell malignancies. Cellular transitions for B cell generation have been associated with gene activation ...
[eng] Lysinuric Protein Intolerance (LPI) is a rare autosomal recessive disorder caused by mutations in the SLC7A7 gene, which encodes the y+LAT1 transporter. LPI presents a pleiotropic phenotype that varies among patients, ...
