Garcia Cabau, Carla (Date of defense: 2022-05-31)
Intrinsically disordered (ID) proteins or regions are protein sequences that lack stable secondary and tertiary structures. ID proteins are particularly prone to undergo liquid- liquid phase separation ...
Aseeri, Mazen (Date of defense: 2023-03-13)
[eng] The main goals of this PhD thesis are closely related within the field of CDases and their key role in the regulation of sphingolipid metabolism. Thus, the roles of ACER3 and AC in different human ...
da Rocha, Pedro Filipe Simões (Date of defense: 2022-11-25)
[eng] Treatment landscape in early-stage NSCLC is rapidly changing after approval of anti-PD-1/PD-L1 in the neoadjuvant and adjuvant settings, respectively. However, biomarkers for patient selection, ...
Torrealba Sandoval, Débora Alejandra (Date of defense: 2016-06-03)
El mantenimiento de la homeostasis del sistema inmune innato es fundamental, ya que éste debe mantener una respuesta equilibrada frente a los patógenos. En mamíferos, uno de los mecanismos por el cual ...
Ruiz Cánovas, Eugenia (Date of defense: 2018-12-10)
Compound F has been reported to possess important antioxidant, anti-inflammatory, anti- diabetic and anti-cancer effects, among other interesting properties. Although Compound F has been extensively ...
Henryka Gawrzak, Sylwia (Date of defense: 2016-11-23)
Breast cancer is the most frequently diagnosed cancer and remains the second leading cause of death among women in Europe and United States. In this malignancy, metastasis remains to be an incurable ...
Sabbaghi Mehrjardi, Mohammad Ali (Date of defense: 2017-09-19)
Trastuzumab-emtansine (T-DM1) is an antibody-cytotoxic agent (DM1) conjugated drug. DM1 delivery by trastuzumab inside the HER2 positive cells affects microtubule polymerization, cell cycle arrest and ...
Paz Domínguez, Joel (Date of defense: 2021-12-14)
Despite decades of work, the molecular requirements underlying microtubule- organizing center (MTOC) formation at the centrosome remain obscure. Progress is hindered by the complexity of this organelle, ...
Tristán Noguero, Alba (Date of defense: 2019-11-22)
Monoamine Neurotransmitter diseases are a rare group of inherited disorders of metabolism that encompass 12 different genetic defects leading to abnormal dopamine and/or serotonin brain homeostasis. ...
Rasti Zaghiyan, George (Date of defense: 2021-09-20)
The Sirtuin family of NAD+-dependent enzymes plays a key role in the maintenance of genome integrity upon stress. Sirtuins coordinate the response to different forms of stress at different levels and ...