Ivani, Iván (Date of defense: 2016-12-13)
Classical force fields are the core of classical simulations, particularly of molecular dynamics (MD), a technique that is changing our view on the structure, flexibility and function of biological ...
Azagra Rodríguez, Alba (Date of defense: 2019-11-29)
B lymphopoiesis is the result of several cell lineage choices and differentiation steps whose perturbation leads to B cell malignancies. Cellular transitions for B cell generation have been associated ...
Bagiński, Błażej Mikołaj (Date of defense: 2022-12-15)
[eng] Tumour progression largely depends on the signalling networks that direct cell viability, growth and dissemination (metastasis). Transforming growth factor beta (TGF-β) and Bone Morphogenetic ...
Mendoza Blanco, Mónica (Date of defense: 2023-11-24)
[eng] Neurons are highly polarized cells that require protein synthesis in distal dendrites to fulfil local protein requirements on short timescales. The regulation of this process relies in two major ...
Giroud-Gernetant Deus, Judith (Date of defense: 2023-11-20)
[eng] Lysinuric Protein Intolerance (LPI) is a rare autosomal recessive disorder caused by mutations in the SLC7A7 gene, which encodes the y+LAT1 transporter. LPI presents a pleiotropic phenotype that ...
Ruiz Serra, Victoria Isabel (Date of defense: 2023-11-08)
[eng] Proteins are fundamental building blocks of life, and understanding their structure and function is crucial for many fields of science, from drug discovery to bioengineering. Traditional experimental ...
Doria Belenguer, Sergio (Date of defense: 2023-10-07)
[eng] Advances in capturing technologies have yielded a massive production of large-scale molecular data that describe different aspects of cellular functioning. These data are often modeled as networks, ...
Borràs Eroles, Clara (Date of defense: 2023-02-09)
[eng] The lungs are constantly exposed to external particles and microbes, so their particular immune environment is immunosuppressive to avoid unnecessary inflammatory responses. This increases the ...
Trujillano Fernández, Alejandro (Date of defense: 2024-02-08)
[eng] DYRK1A is a kinase that is expressed in virtually all tissues and cell types and is implicated in human diseases. Several studies indicate that DYRK1A is a dose-dependent gene with a prevalent ...