Facultat de Biologia: Envíos recientes
Mostrando ítems 101-120 de 236
Modeling neurofibromatosis type1 neurofibroma composition and formation
Neurofibromatosis type 1 (NF1) is a genetic disease caused by inherited mutations in the NF1 gene. NF1 is a cancer predisposition syndrome, and the disease’s hallmark is the appearance of tumors of the peripheral nervous ...
Evaluación de la vulnerabilidad y del estado de conservación de ecosistemas marinos bentónicos especialmente productivos del Mediterráneo frente al impacto de la pesca de arrastre, para impulsar su correcta gestión
En el mar Mediterráneo existen hábitats especialmente productivos como los fondos de maërl y de agregación de crinoideos, que son explotados en la actualidad por la flota de arrastre. Esta actividad supone un impacto que ...
Study of complex chromosomal rearrangements in cancer. The role of extrachromosomal circular DNA as a genome remodeler in neuroblastoma
This thesis illustrates the work I have developed as a Ph.D. student in the computational genomics group lead by Dr. David Torrents at the Barcelona Supercomputing Center. The group’s expertise in the analysis of biological ...
Deciphering the molecular and phenotypic effects of a Drosophila melanogaster transposable element located in a unique insertional cluster
Understanding how organisms adapt to their environment remains an open question in Biology. So far, most projects focus on the study of single nucleotide polymorphism variants, while other types of mutations, likely to ...
Environmental effects during gonadal development in fish: role of epigenetics
In many organisms, sex is determined by a combination of genetic and environmental influences. Epigenetic regulatory mechanisms such as DNA methylation integrate both types of influences. However, understanding how genetic ...
Molecular mechanisms for active DNA demethylation in cellular immune models
Epigenetic factors, such as histone post-translational modifications and DNA methylation, are critical determinants of gene expression, which ultimately defines cell identity and function. Despite intense research in DNA ...
Alternative splicing control over naïve and primed pluripotency
A fundamental step in embryo development is the transition through pluripotency. There are two known sequential states of pluripotency termed naïve and primed pluripotency. Considerable efforts have been made to characterize ...
Papel del Polietilenglicol 35 en la Modulación de los Procesos Inflamatorios Asociados al Páncreas
A pesar de las extensas investigaciones durante las últimas décadas, la pancreatitis aguda (PA) continúa siendo un reto para el manejo clínico, con una importante carga de morbilidad, mortalidad y coste, cuando la enfermedad ...
Composition, remodeling and dynamics of the CPEB RNP
Xenopus laevis oocytes are transcriptionally silent cells that require hormone stimulation for maturing into fecundation-competent eggs. Meiosis resumption underlying oocyte maturation is governed by sequential waves of ...
Estudio topológico del ADN nucleosomal y su paradoja del número de enlace
El empaquetamiento del ADN en fibras de cromatina implica una gran cantidad de deformaciones geométricas de la doble hélice (enrollamiento y superenrollamiento del ADN) y la formación de una jerarquía de asas o dominios ...
β-cells cis-regulatory networks and type 1 diabetes
Type 1 Diabetes (T1D) is a celltargeted autoimmune disease, leading to a reduction in pancreatic cell mass that renders patients insulindependent for life. In early stages of the disease, cells from the immune system ...
L´hemostàsia primària en la trombosi venosa. Biomolècules implicades en la formació del coàgul plaquetari: paper de VAMP8, SERT, SEROTONINA, ADAMTS13 i Factor von Willebrand
La patologia associada a l’hemostàsia primària ha estat clàssicament relacionada amb diàtesi hemorràgica (malaltia de von Willebrand, Síndrome de Bernard- Soulier, malaltia de Glanzmann, trombopènia, etc) on s’ha valorat ...
Comprehensive study of 3D chromatin structure
The connection between DNA folding and chromatin conformation has been much studied but the relation between the modulation of chromatin conformation and biological processes such as DNA damage, cell differentiation and ...
Estimation of phylogeographic patterns and divergence times of populations of small mammals from the Iberian Peninsula using genomic data
Phylogenetic and phylogeographic methods allow studying the evolutionary relationships between populations and species, patterns of genetic structure, and historical events that have modelled the current distribution of ...
Detection and classification of somatic structural variants, and its application in the study of neuronal development
The identification and analysis of genomic variation across individuals has been central in biology, first through comparative genomics to answer evolutionary questions, and then in the context of biomedicine, where it is ...
Understanding chromosomal instability-induced senescence
Aneuploidy, defined as a chromosome number that deviates from a multiple of the haploid set, is a common feature in human cancer, and around 70% of human solid tumours are aneuploid. The resulting metabolic imbalance is ...
Caracterización de los eventos inmunológicos diferenciales en pacientes con cáncer de pulmón de célula pequeña tratados con quimioterapia con o sin ipilimumab
El cáncer de pulmón de célula pequeña (CPCP) es el subtipo mas agresivo del cáncer de pulmón. Mas de la mitad de los pacientes se diagnostican con enfermedad diseminada, donde el tratamiento de elección desde la década de ...
Estudi de l'oncostatina M i de la termogènesi del teixit adipós marró, abans i després de la cirurgia bariàtrica
L’obesitat és una patologia crònica que en les darreres dècades s’ha incrementat de manera alarmant al món especialment en els països mes desenvolupats. Malgrat que la dieta i l’exercici físic són dos agents primordials ...
Macro- and micro -symbioses involving sponges: Ecological roles in the marine benthos
The symbiotic lifestyle represents a fundamental contribution to the diversity of marine ecosystems. Sponges are ideal models to study symbiotic relationships from evolutionary and ecological points of view since they are ...
Regulation of ribonucleotide reduction in facultative anaerobic pathogens and its influence in bacterial fitness, virulence and biofilm formation
The perpetuation of life depends on the ability to reproduce. All known forms of life use DNA as genetic information storage. Ribonucleotide reduction is the process by which ribonucleotides (NTPs) are transformed into ...
