La Universitat de Barcelona és la universitat pública principal de Catalunya, amb el nombre més gran d’estudiants i l’oferta formativa més àmplia i completa. A més, és el principal centre de recerca universitari de l’Estat i un dels més importants d’Europa, tant per nombre de programes de recerca com per l’excel·lència assolida en aquest terreny.Estretament vinculada a la història de Barcelona i de Catalunya, la UB combina els valors de la tradició amb el fet de ser una institució innovadora i d’excel·lència en l’àmbit docent, i és una universitat urbana, oberta i cosmopolita com la mateixa ciutat de Barcelona.Us convidem a conèixer la Universitat de Barcelona!
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Bartomeu i Galan, Anna (Fecha de defensa: 2024-01-29)
[eng] Cytoplasmic Polyadenylation Element Binding proteins (CPEBs) are a family of RNA-binding proteins that regulate cytoplasmic changes in poly(A) tail lengh and therefore mRNA-specific stability and translation. Since ...
Trujillano Fernández, Alejandro (Fecha de defensa: 2024-02-08)
[eng] DYRK1A is a kinase that is expressed in virtually all tissues and cell types and is implicated in human diseases. Several studies indicate that DYRK1A is a dose-dependent gene with a prevalent function in brain ...
Calvo Serrano, Isabel (Fecha de defensa: 2024-02-16)
[eng] Our understanding of the transcriptional control of cellular identity is rapidly emerging. Mediator complex enriches at active enhancers, forms a protein bridge to target genes, and recruits RNA Polymerase II ...
Salvadores Ferreiro, Marina (Fecha de defensa: 2024-01-18)
[eng] Mutations exhibit an uneven distribution across the human genome, with a regional mutation density (RMD) influenced by chromatin landscapes and replication timing. While there is a good understanding of this variation, ...
Xiol Viñas, Clara (Fecha de defensa: 2023-12-22)
[eng] Rett syndrome (RTT) is a severe neurodevelopmental disorder characterized by a regression in acquired skills, such as purposeful hand use and language, after an apparently normal early development. RTT affects ...
Qualai, Jamal (Fecha de defensa: 2023-12-04)
[eng] Common sexually transmitted infections like gonorrhea, Chlamydia, syphilis, and trichomoniasis are the leading cause of morbidity in developing countries. Adolescents and young women have the highest rates of STIs ...
Özkan, Selen (Fecha de defensa: 2023-12-01)
[eng] Precision medicine aims to provide personalized patient care using genetic data. However, interpreting the phenotypic consequences of genetic variants remains a bottleneck in both clinical and research settings. ...
Molina Jordán, Marc (Fecha de defensa: 2023-12-04)
[eng] The application of mechanical force to the nucleus has been recently shown to regulate important functions, including nucleocytoplasmic transport (NCT), chromatin organization, and gene expression. However, how ...
Schikora Tamarit, Miquel Àngel (Fecha de defensa: 2023-11-03)
[eng] Fungal infections pose a serious health threat, affecting >1,000 million people and causing ~1.5 million deaths each year. The problem is growing due to insufficient diagnostic and therapeutic options, increased ...
Doria Belenguer, Sergio (Fecha de defensa: 2023-10-07)
[eng] Advances in capturing technologies have yielded a massive production of large-scale molecular data that describe different aspects of cellular functioning. These data are often modeled as networks, in which nodes are ...
Ruiz Serra, Victoria Isabel (Fecha de defensa: 2023-11-08)
[eng] Proteins are fundamental building blocks of life, and understanding their structure and function is crucial for many fields of science, from drug discovery to bioengineering. Traditional experimental methods for ...
Giroud-Gernetant Deus, Judith (Fecha de defensa: 2023-11-20)
[eng] Lysinuric Protein Intolerance (LPI) is a rare autosomal recessive disorder caused by mutations in the SLC7A7 gene, which encodes the y+LAT1 transporter. LPI presents a pleiotropic phenotype that varies among patients, ...
Vilar Ribó, Laura (Fecha de defensa: 2023-11-20)
[eng] Substance use disorders (SUDs) are psychiatric disorders characterized by a recurring desire to continue taking a substance regardless of its destructive consequences. The etiology of SUDs is complex and multifactorial, ...
Muñoz Pujol, Gerard (Fecha de defensa: 2023-11-23)
[cat] Les malalties metabòliques hereditàries (MMH) són un grup de patologies amb una gran heterogeneïtat clínica, bioquímica i genètica. Actualment se n’han descrit més de 1 800. En l’última dècada la implementació de ...
Mendoza Blanco, Mónica (Fecha de defensa: 2023-11-24)
[eng] Neurons are highly polarized cells that require protein synthesis in distal dendrites to fulfil local protein requirements on short timescales. The regulation of this process relies in two major sub processes: the ...
Sánchez Baizán, Núria (Fecha de defensa: 2023-10-27)
[eng] Epigenetic mechanisms play a vital role in gene expression regulation and phenotype determination. This thesis aimed to comprehensively investigate the transcriptome, the methylome and the influence of intrinsic (such ...
Matías Sánchez, Daniel (Fecha de defensa: 2023-10-27)
[eng] In recent years, the genetics field has placed a significant emphasis on identifying and characterizing genetic factors contributing to complex diseases, alongside environmental factors. Genome-wide association ...
Tello Velasco, Daniel (Fecha de defensa: 2023-09-19)
[eng] For this purpose, Spatial Analysis of Functional Enrichment (SAFE) framework was proposed to uncover functional regions in a network by embedding it in 2-dimensions (2D) using the Spring embedding algorithm. However, ...
Salinas Pena, Mónica (Fecha de defensa: 2023-09-20)
[eng] The histone H1 family comprises up to seven members in human somatic cells. However, H1 studies have been limited by the lack of specific ChIP-grade antibodies. Here, we have mapped six endogenous H1 variants in T47D ...
Moreno Aguilera, Marcos (Fecha de defensa: 2023-09-29)
[spa] El splicing alternativo es un proceso que además de proporcionar diversidad al transcriptoma y proteoma celular, añade una nueva capa de regulación en la expresión de proteínas y en la función que estas desempeñan. ...