Departament de Química Inorgànica i Orgànica: Recent submissions
Now showing items 21-40 of 93
Development of novel nanomedicines based on polyurethane-polyurea hybrid nanocapsules for cancer theragnosis
[eng] Nanomedicine is one of the cutting-edge fields in most of medical applications, specially, in oncology. The possibility to selectively vehiculize and specifically release a wide range of anticancer compounds gained ...
New organic semiconductors based on the carbazole core: synthesis and application in optoelectronic devices
[eng] The increasing demand on next-generation displays encourages an exhaustive research on the development of new and enhanced semiconductors. Apart from the conventional inorganic materials, organic-based semiconductors ...
P-Stereogenic ligands: synthesis and application to asymmetric hydrogenation
[eng] P-Stereogenic ligands have demonstrated to be highly efficient for asymmetric catalysis, especially in metal-catalyzed asymmetric hydrogenation reactions. Among them, those bearing bulky substituents at phosphorus ...
Optimización de etapas claves en la síntesis de Palmerolidas. Síntesis de la Palmerolida
[spa] En el primer bloque de la tesis describimos nuestra aproximación a la síntesis total de la Palmerolida D, un compuesto de gran interés, tanto por sus propiedades antitumorales como por la diversidad de reacciones ...
Understanding the physical origin, topology and strength of noncovalent interactions by means of computational tools
The structure and stability of molecules, the formation of supramolecular aggregates in the solid state or in solution and, therefore, many chemical and biological processes in which they participate depend heavily on ...
Enolates Go Radical. Stereoselective Radical Alkylation Reactions of Titanium Enolates from N-Acyl Oxazolidinones with Carboxylic Acid Derivatives. Synthesis of Umuravumbolide
This thesis consists in the development of a new methodology of α-alkylation of carbonyl compounds and its application to the synthesis of small molecules with therapeutic interest. In this context, the alkylation of ...
Design, synthesis and evaluation of the biological properties of colistin analogues
Following the laws of evolution, bacteria are capable of slowly but inexorably acquiring resistance to antibiotic compounds that we have been using for decades. Therefore, bacteria that seemed harmless to most people (such ...
Novel antimicrobial peptides for therapeutic applications: design, synthesis, characterization, and evaluation of their biological and biophysical activity
After decades of exorbitant antibiotic misuse and overuse in human medicine, agriculture and livestock industry, multidrug resistant bacteria (MDR) have become a major medical concern. In this regard, the design of new, ...
Design, synthesis and study of coordination complexes with spin crossover or single-molecule magnet properties
Spin crossover (SCO) complexes and single-molecule magnets (SMMs) are promising prototypes that can reach magnetic bistability within the molecular scale required for data storage. Despite the extensive library of versatile ...
Luminescent gold(I) supramolecular assemblies on materials and biological chemistry
During the last years, the research group where this Doctoral Thesis has been carried out has been pioneer in the development of different gold(I) complexes and resulting supramolecular assemblages with a wide variety of ...
Desenvolupament de processos per a la síntesi de pèptids d’interès terapèutic a escala industrial
Investigacions recents en el camp de la biomedicina han demostrat que les interaccions entre pèptids i macromolècules com ara les proteïnes, modulen i regulen processos biològics importants com la memòria, la resposta a ...
Insights into the myristoylated c-Src N-terminal Regulatory Element
c-Src is a non-receptor tyrosine kinase that controls numerous cellular signaling pathways. c-Src implication in human cancers was brought into the attention in the 1980s. Since its discovery, unveiling of c-Src ...
Molecular-based Magnetoresistance Devices at Room Temperature
In this doctoral thesis a series of computational and experimental studies of molecular magnetoresistance devices at room temperature is presented. This sort of devices is included in the molecular electronics framework ...
Drug discovery with a FRET Biosensor of scaffolding interactions in the N-terminal region of c-Src = Descubrimiento de fármacos mediante un biosensor basado en FRET sensible a las interacciones en la región N-terminal de c-Src
c-Src tyrosine kinase is associated with poor prognosis in many cancer processes. Although inhibitors of c-Src kinase activity are known, they have not reached success in clinical trials because of lack of selectivity or ...
Mechanistic insights into substrate-assisted catalysis in glycosidases by means of QM/MM molecular dynamics
Carbohydrates are essential molecules in biotechnology and for the proper functioning of living organisms. They are involved in energy storage, being structural components or participating in crucial biological processes ...
The development of new, direct and asymmetric Ni(II) catalysed carbon-carbon bond forming reactions and their application to total synthesis
This thesis focuses on the search for new methodologies for the direct, stereoselective and catalytic formation of carbon-carbon bonds through the formation of chiral nickel(II) enolate species and the application of such ...
Reacciones directas de la N-azidoacetil-1,3-tiazolidin-2-tiona catalizadas por complejos quirales de níquel(II) para la construcción enantioselectiva de enlaces carbono-carbono. Síntesis de la lacosamida y derivados de la β-hidroxifenilalanina
En esta Tesis Doctoral se han explorado y optimizado nuevas metodologías enantioselectivas y directas de formación de enlaces carbono-carbono catalizadas por complejos quirales de níquel(ll). Esencialmente, se han estudiado ...
New Catalytic Methods for Pauson-Khand Reactions, Isomerization and Asymmetric Hydrogenations. Application to the Synthesis of Bioactive Compounds
The main contribution of this doctoral thesis has been devoted to the field of synthetic organic chemistry. The Pauson-Khand reaction (PKR) is a metal-catalyzed [2+2+1] cycloaddition between an alkyne, an alkene and a ...
Organocatálisis y transferencia de quiralidad mediante porfirinas autoensamblantes solubles en agua
La quiralidad es una propiedad fundamental de la naturaleza. La vida en la Tierra se basa en la quiralidad. Casi todos los compuestos quirales presentes en los organismos vivos se encuentran solo en una de sus formas ...
Studies on the formation of i-motif structures at neutral pH. Use of cytidine analogues and importance of minor groove tetrads on mini i-motifs stabilization
Given the increasing interest in i-motif structures, obtaining such structures as well as detailed structural information under physiological conditions have become hot topics in the structural biology field. In this ...
