Now showing items 6-25 of 67
Rossell Rusiñol, Joana (Date of defense: 2021-02-26)
An unbalanced, unhealthy diet is one of the main causes leading to obesity and the apparition of comorbidities. Bariatric surgery is currently the most effective and durable treatment against obesity. Despite being a ...
Nukala, Sarath Babu (Date of defense: 2019-05-23)
The vascular endothelium is one of the major targets of oxidative stress, playing an important role in the development of vascular-related disorders, such as atherosclerotic disease1. Oxidative stress increases the formation ...
Serrano Novillo, Clara (Date of defense: 2020-01-17)
Voltage gated K+ channels (Kv) are transmembrane proteins that allow the pass-thorugh of potassium ions, regulating the electrochemical gradient of the cell membrane. This way, they modulate several physiological processes, ...
Carretero Paulet, Lorenzo (Date of defense: 2003-04-11)
Los isoprenoides (o terpenoides) constituyen una vasta familia de compuestos de muy diversa naturaleza estructural y funcional presentes en todos los seres vivos. Los isoprenoides sintetizados por las plantas representan ...
Cano Crespo, Sara (Date of defense: 2019-06-26)
The wide variety of disorders associated with the malfunction of amino acid (AA) transporters reflect the relevant roles they fulfil in human physiology. Heteromeric AA transporters (HATs), one of the eleven families of ...
Zodda, Erika (Date of defense: 2019-12-13)
The endothelium plays a pivotal role in the development of cardiovascular disease (CVD) and emerging evidence indicates that pathological blood vessel responses and endothelial dysfunction are associated with metabolic ...
Baptista, Inês do Carmo Viegas (Date of defense: 2022-04-07)
Leukaemia is one of the types of cancer where treatment resistance is prevalent. Better understanding of leukemic cells metabolism opens possibilities for new therapeutic strategies and better prognosis stratification. ...
Casanovas Ferrero, Mireia (Date of defense: 2021-09-06)
Actualmente, entre el 30-40% de los medicamentos comercializados tienen como diana a un receptor acoplado a proteína G (GPCR). Además, la capacidad que tienen estos receptores para interaccionar físicamente entre ellos y ...
Contreras Mostazo, Miriam Guadalupe (Date of defense: 2020-10-21)
Cancer cells, including leukemic cells, can react to therapeutic treatment by altering their metabolic phenotype (“metabolic reprogramming”) to keep their accelerated proliferative state, eventually becoming resistant to ...
Viel Oliva, Albert (Date of defense: 2017-06-16)
Els nucleòsids són metabòlits imprescindibles per a la cèl·lula ja que són els precursors d’un gran nombre de biomolècules. Aquests nucleòsids poden ser sintetitzats per la cèl·lula o es poden recuperar del medi extracel·lular ...
Royo Garrido, Romina (Date of defense: 2023-03-31)
[eng] Next-generation sequencing (NGS) has revolutionized biomedical sciences, especially in the area of cancer. It has nourished genomic research with extensive collections of sequenced genomes that are investigated to ...
Foguet Coll, Carles (Date of defense: 2019-12-20)
Metabolism is a hallmark of life and underlies most biological processes in both health and disease. For instance, dysregulation of liver metabolism underlies multifactorial disorders such as diabetes or obesity. Similarly, ...
Casadó Mora, Ana (Date of defense: 2017-12-15)
El cáncer de colon representa entre el 10-12% de las enfermedades neoplásicas y es una de las causas principales de muerte por cáncer en los países occidentales. Fármacos como el irinotecan, inhibidor de la topoisomerasa ...
Prieto Carruyo, Andrea Valentina (Date of defense: 2023-12-15)
[spa] Aún queda mucho por conocer sobre la regulación de la función de los transportadores concentrativos de nucleósidos hCNTs. A pesar de que se expresan en muchos tipos de tejidos, su localización no es ubicua y varía ...
Castellanos Martínez, Antonio (Date of defense: 2021-03-22)
En la enfermedad de Huntington (HD), muchos síntomas están asociados con alteraciones en las funciones reguladas por la dopamina y el glutamato; una intervención directa sobre los receptores de dopamina D1 (D1R) pueden ...
Delgado Anglés, Alejandro (Date of defense: 2021-10-25)
Brown and beige adipose tissues are mediators of adaptive energy expenditure in mammals, in contrast with the energy storage role of white fat. Mitochondrial activity, including uncoupled respiration, and the release of ...
Rivas Santisteban, Rafael (Date of defense: 2021-10-15)
Los receptores acoplados a proteína G o GPCRs conforman la mayor familia de receptores de membrana celular en organismos eucariotas. En humanos se han descrito más de 800 GPCRs, gran parte de ellos descubiertos mediante ...
Pérez Olives, Catalina (Date of defense: 2023-11-17)
[eng] Adenosine and endocannabinoids are regulatory molecules that are present in all organ and physiological systems. They act via specific receptors belonging to the G protein-coupled receptor (GPCR) superfamily. There ...
Mas Marin, Eduard (Date of defense: 2021-07-23)
Nucleoside transporters are essential for nucleotide homeostasis as well as for nucleoside-derived drugs bioavailability. Non-canonical natural nucleosides or “epigenetic nucleosides” are endogenously produced and possess ...