Now showing items 24-43 of 67
Mas Marin, Eduard (Date of defense: 2021-07-23)
Nucleoside transporters are essential for nucleotide homeostasis as well as for nucleoside-derived drugs bioavailability. Non-canonical natural nucleosides or “epigenetic nucleosides” are endogenously produced and possess ...
Campderrós Traver, Laura (Date of defense: 2019-07-19)
L’obesitat s’ha convertit en les últimes dècades en un greu problema per la salut pública arribant a ser una de les principals causes de morbiditat, incapacitació i mortalitat prematura. Un teixit que pot tenir un paper ...
Serrano Albarrás, Antonio (Date of defense: 2018-11-23)
Ion channels are transmembrane proteins containing aqueous pores which, once open, permit the pass of ions through the plasma membrane. This ion flux takes places following the electrochemical gradient for the specific ...
Etayo Labiano, Iñigo Javier (Date of defense: 2018-05-15)
Los receptores de cannabinoides, CB1R y CB2R, que forman parte del sistema endocannabinoide, pertenecen a la superfamilia de receptores acoplados a proteína G (GPCR). El sistema endocannabinoide se encuentra estrechamente ...
Reyes Resina, Irene (Date of defense: 2018-06-11)
Los receptores cannabinoides CB1R y CB2R son GPCRs que forman parte del sistema endocannabinoide y son considerados dianas potenciales para numerosas enfermedades. Su compleja farmacología junto con la naturaleza lipofílica ...
Rodríguez Ruiz, Mar (Date of defense: 2018-09-10)
Los GPCRs son proteínas de membrana versátiles capaces de ser activadas por una amplia variedad de estímulos y son responsables de la transducción de señales extracelulares de manera específica. Regulan múltiples procesos ...
Medrano Moya, Mireia (Date of defense: 2017-06-23)
La oligomerización es un proceso común en la biología de los receptores de membrana, compartida por los GPCRs. Los GPCRs constituyen aproximadamente un 45% de las dianas de los fármacos comercializados en la actualidad y ...
Boces Pascual, Clara (Date of defense: 2020-06-17)
Human Concentrative Nucleoside Transporters (hCNTs) are encoded by SLC28 gene family. It has been demonstrated that hCNT1 is lost in some cancers. Furthermore, hCNTs have the ability of translocating selected nucleoside- ...
Aguinaga Andrés, David (Date of defense: 2017-07-13)
Actualmente en la comunidad científica aún existe debate acerca de la heteromerización entre receptores GPCR y el papel que esta tiene en la señalización y funcionalidad celular. Tradicionalmente estos receptores han sido ...
Díaz Sáez, Francisco (Date of defense: 2021-02-12)
Neuregulin-4 has emerged as a novel adipokine in recent years. Several authors have previously explored the endocrine role of this adipocyte-secreted growth factor in the liver metabolism. In those studies, it has been ...
Castellá Giner, Moisés (Date of defense: 2023-09-29)
[emg] Alternative splicing (AS) is a gene expression regulatory mechanism that enables generation of multiple mRNA isoforms from a single gene which commonly are translated into proteins. This mechanism is tightly regulated ...
Badia Villanueva, Míriam (Date of defense: 2019-10-14)
La lipoproteïna lipasa (LPL) és un enzim àmpliament distribuït a l’organisme i aquest fet li confereix un rol central en el metabolisme lipídic. La seva funció principal és la hidròlisi dels triacilglicèrids de les ...
Carulla i Sanmartí, Pere (Date of defense: 2017-12-01)
Un dels principals aspectes que hem descrit ha estat la presència i la distribució de les isoformes de pI de l’LPL. Inicialment hem treballat amb teixits de rata adulta: cor, TAB, TAM i múscul. Els resultats han demostrat ...
Perelló-Reus, Catalina (Date of defense: 2020-06-02)
Maintenance of balanced nucleotide pools is necessary for cellular homeostasis. The nucleotide content of the cell is determined by the uptake of nucleosides by specific transporters, the salvage pathway and de novo synthesis ...
Barros, Susana Raquel Costa (Date of defense: 2020-02-13)
OPA1 is a dynamin-related protein that is responsible for the fusion of the internal mitochondrial membrane and essential to control the morphology of the mitochondrial cristae. Thus, it directly impacts the efficiency of ...
Irazoqui Guimon, Andrea (Date of defense: 2021-12-03)
Some forms of mitochondrial dysfunction induce sterile inflammation through mitochondrial DNA (mtDNA) recognition by intracellular DNA sensors. However, our understanding of the processes operating this activation is ...
Sastre Martinez, Daniel (Date of defense: 2022-04-08)
Kv1.3 plays a crucial role in leukocytes, where it regulates activation and proliferation. In these cells, Kv1.3 is coexpressed with modulatory subunit KCNE4. This ancillary peptide acts as a dominant negative regulator ...
Núñez Carpintero, Iker (Date of defense: 2023-11-14)
[eng] The vast and continuously increasing volume of available biomedical data produced during the last decades opens new opportunities for large-scale modeling of disease biology, facilitating a more comprehensive and ...
Sánchez Soto, Marta (Date of defense: 2017-01-16)
From the D2‐like receptors (D2,D3, D4), only D4 receptor (D4R) has been described as “promiscuous” since it can be activated both by dopamine (DA) and norepinephrine (NE) and function as a noradrenergic receptor in the ...