1. Home
  2. Universitat de Barcelona
  3. Departament de Bioquímica i Biomedicina Molecular
  4. Browsing Departament de Bioquímica i Biomedicina Molecular by Title

Browsing Departament de Bioquímica i Biomedicina Molecular by Title

Now showing items 6-25 of 66

    Bariatric surgery and diet change in rats 

    Rossell Rusiñol, Joana (Date of defense: 2021-02-26)

    An unbalanced, unhealthy diet is one of the main causes leading to obesity and the apparition of comorbidities. Bariatric surgery is currently the most effective and durable treatment against obesity. Despite being a ...

    Bioanalytical and proteomic approaches in the study of pathologic ECs dysfunctionality, oxidative stress and the effect of PFKFB3 modulators 

    Nukala, Sarath Babu (Date of defense: 2019-05-23)

    The vascular endothelium is one of the major targets of oxidative stress, playing an important role in the development of vascular-related disorders, such as atherosclerotic disease1. Oxidative stress increases the formation ...

    Biology of the cardiovascular Kv7.1 functional complex 

    Serrano Novillo, Clara (Date of defense: 2020-01-17)

    Voltage gated K+ channels (Kv) are transmembrane proteins that allow the pass-thorugh of potassium ions, regulating the electrochemical gradient of the cell membrane. This way, they modulate several physiological processes, ...

    Caracterización a nivel molecular de los genes 1-desoxi-D-xilulosa 5-fosfato sintasa y 1-desoxi-D-xilulosa 5-fosfato reductoisomerasa de Arabidopsis thaliana 

    Carretero Paulet, Lorenzo (Date of defense: 2003-04-11)

    Los isoprenoides (o terpenoides) constituyen una vasta familia de compuestos de muy diversa naturaleza estructural y funcional presentes en todos los seres vivos. Los isoprenoides sintetizados por las plantas representan ...

    CD98hc orchestrates amino acid and glucose availability, redox homeostasis and energetic and nucleotide metabolism = CD98hc sostiene la disponibilidad de aminoácidos y glucosa, la homeóstasis óxido-reducción y el metabolismo energético y de nucleótidos 

    Cano Crespo, Sara (Date of defense: 2019-06-26)

    The wide variety of disorders associated with the malfunction of amino acid (AA) transporters reflect the relevant roles they fulfil in human physiology. Heteromeric AA transporters (HATs), one of the eleven families of ...

    Characterization of Endothelial Cells dysfunction associated to Acute Myocardial Infarction: modulation of metabolic pathways as a new therapeutic approach 

    Zodda, Erika (Date of defense: 2019-12-13)

    The endothelium plays a pivotal role in the development of cardiovascular disease (CVD) and emerging evidence indicates that pathological blood vessel responses and endothelial dysfunction are associated with metabolic ...

    Characterization of the role of TKTL1 in Acute Monocytic Leukaemia 

    Baptista, Inês do Carmo Viegas (Date of defense: 2022-04-07)

    Leukaemia is one of the types of cancer where treatment resistance is prevalent. Better understanding of leukemic cells metabolism opens possibilities for new therapeutic strategies and better prognosis stratification. ...

    Complejos del receptor sigma y de heterómeros de receptores acoplados a proteínas G en adicción y control de apetito 

    Casanovas Ferrero, Mireia (Date of defense: 2021-09-06)

    Actualmente, entre el 30-40% de los medicamentos comercializados tienen como diana a un receptor acoplado a proteína G (GPCR). Además, la capacidad que tienen estos receptores para interaccionar físicamente entre ellos y ...

    Definition and validation of targets associated with the metabolic reprogramming of haematological malignancies 

    Contreras Mostazo, Miriam Guadalupe (Date of defense: 2020-10-21)

    Cancer cells, including leukemic cells, can react to therapeutic treatment by altering their metabolic phenotype (“metabolic reprogramming”) to keep their accelerated proliferative state, eventually becoming resistant to ...

    Determinants estructurals i implicacions funcionals de l'interactoma proteic d'hCNT1 

    Viel Oliva, Albert (Date of defense: 2017-06-16)

    Els nucleòsids són metabòlits imprescindibles per a la cèl·lula ja que són els precursors d’un gran nombre de biomolècules. Aquests nucleòsids poden ser sintetitzats per la cèl·lula o es poden recuperar del medi extracel·lular ...

    Development and application of methodologies and infrastructures for cancer genome analysis within Personalized Medicine 

    Royo Garrido, Romina (Date of defense: 2023-03-31)

    [eng] Next-generation sequencing (NGS) has revolutionized biomedical sciences, especially in the area of cancer. It has nourished genomic research with extensive collections of sequenced genomes that are investigated to ...

    Development of model-driven approaches for metabolic flux analysis and anticancer drug discovery 

    Foguet Coll, Carles (Date of defense: 2019-12-20)

    Metabolism is a hallmark of life and underlies most biological processes in both health and disease. For instance, dysregulation of liver metabolism underlies multifactorial disorders such as diabetes or obesity. Similarly, ...

    Diseño de nuevas formulaciones farmacéuticas mucoadhesivas para la quimioterapia del cáncer de colon 

    Casadó Mora, Ana (Date of defense: 2017-12-15)

    El cáncer de colon representa entre el 10-12% de las enfermedades neoplásicas y es una de las causas principales de muerte por cáncer en los países occidentales. Fármacos como el irinotecan, inhibidor de la topoisomerasa ...

    Estudio de la interacción de hCNT3 y QDPR como nexo funcional entre la recuperación de nucleósidos y sus vías biosintéticas 

    Prieto Carruyo, Andrea Valentina (Date of defense: 2023-12-15)

    [spa] Aún queda mucho por conocer sobre la regulación de la función de los transportadores concentrativos de nucleósidos hCNTs. A pesar de que se expresan en muchos tipos de tejidos, su localización no es ubicua y varía ...

    Estudios de la interacción de los receptores de dopamina con otros receptores implicados en la enfermedad de Huntington 

    Castellanos Martínez, Antonio (Date of defense: 2021-03-22)

    En la enfermedad de Huntington (HD), muchos síntomas están asociados con alteraciones en las funciones reguladas por la dopamina y el glutamato; una intervención directa sobre los receptores de dopamina D1 (D1R) pueden ...

    Experimental and human studies on aging of adipose tissues: Role for Parkin 

    Delgado Anglés, Alejandro (Date of defense: 2021-10-25)

    Brown and beige adipose tissues are mediators of adaptive energy expenditure in mammals, in contrast with the energy storage role of white fat. Mitochondrial activity, including uncoupled respiration, and the release of ...

    Expresión y funcionalidad de los heterómeros de GPCR en las enfermedades neurodegenerativas de Parkinson y Alzheimer 

    Rivas Santisteban, Rafael (Date of defense: 2021-10-15)

    Los receptores acoplados a proteína G o GPCRs conforman la mayor familia de receptores de membrana celular en organismos eucariotas. En humanos se han descrito más de 800 GPCRs, gran parte de ellos descubiertos mediante ...

    Expresión y Funcionalidad de Receptores de Cannabinoides y de Adenosina y de sus Heterómeros en modelos de Alzheimer y de Esclerosis Múltiple 

    Pérez Olives, Catalina (Date of defense: 2023-11-17)

    [eng] Adenosine and endocannabinoids are regulatory molecules that are present in all organ and physiological systems. They act via specific receptors belonging to the G protein-coupled receptor (GPCR) superfamily. There ...

    Farmacologia Molecular dels Transportadors de Nucleòsids en Teràpia del Càncer: Nucleòsids Naturals No Canònics i Ruxolitinib 

    Mas Marin, Eduard (Date of defense: 2021-07-23)

    Nucleoside transporters are essential for nucleotide homeostasis as well as for nucleoside-derived drugs bioavailability. Non-canonical natural nucleosides or “epigenetic nucleosides” are endogenously produced and possess ...