Universitat de Barcelona
Now showing items 24-43 of 66
Nucleoside transporters are essential for nucleotide homeostasis as well as for nucleoside-derived drugs bioavailability. Non-canonical natural nucleosides or “epigenetic nucleosides” are endogenously produced and possess ...
L’obesitat s’ha convertit en les últimes dècades en un greu problema per la salut pública arribant a ser una de les principals causes de morbiditat, incapacitació i mortalitat prematura. Un teixit que pot tenir un paper ...
Ion channels are transmembrane proteins containing aqueous pores which, once open, permit the pass of ions through the plasma membrane. This ion flux takes places following the electrochemical gradient for the specific ...
Los receptores de cannabinoides, CB1R y CB2R, que forman parte del sistema endocannabinoide, pertenecen a la superfamilia de receptores acoplados a proteína G (GPCR). El sistema endocannabinoide se encuentra estrechamente ...
Los receptores cannabinoides CB1R y CB2R son GPCRs que forman parte del sistema endocannabinoide y son considerados dianas potenciales para numerosas enfermedades. Su compleja farmacología junto con la naturaleza lipofílica ...
Los GPCRs son proteínas de membrana versátiles capaces de ser activadas por una amplia variedad de estímulos y son responsables de la transducción de señales extracelulares de manera específica. Regulan múltiples procesos ...
La oligomerización es un proceso común en la biología de los receptores de membrana, compartida por los GPCRs. Los GPCRs constituyen aproximadamente un 45% de las dianas de los fármacos comercializados en la actualidad y ...
Human Concentrative Nucleoside Transporters (hCNTs) are encoded by SLC28 gene family. It has been demonstrated that hCNT1 is lost in some cancers. Furthermore, hCNTs have the ability of translocating selected nucleoside- ...
Actualmente en la comunidad científica aún existe debate acerca de la heteromerización entre receptores GPCR y el papel que esta tiene en la señalización y funcionalidad celular. Tradicionalmente estos receptores han sido ...
Neuregulin-4 has emerged as a novel adipokine in recent years. Several authors have previously explored the endocrine role of this adipocyte-secreted growth factor in the liver metabolism. In those studies, it has been ...
[emg] Alternative splicing (AS) is a gene expression regulatory mechanism that enables generation of multiple mRNA isoforms from a single gene which commonly are translated into proteins. This mechanism is tightly regulated ...
La lipoproteïna lipasa (LPL) és un enzim àmpliament distribuït a l’organisme i aquest fet li confereix un rol central en el metabolisme lipídic. La seva funció principal és la hidròlisi dels triacilglicèrids de les ...
Un dels principals aspectes que hem descrit ha estat la presència i la distribució de les isoformes de pI de l’LPL. Inicialment hem treballat amb teixits de rata adulta: cor, TAB, TAM i múscul. Els resultats han demostrat ...
Maintenance of balanced nucleotide pools is necessary for cellular homeostasis. The nucleotide content of the cell is determined by the uptake of nucleosides by specific transporters, the salvage pathway and de novo synthesis ...
OPA1 is a dynamin-related protein that is responsible for the fusion of the internal mitochondrial membrane and essential to control the morphology of the mitochondrial cristae. Thus, it directly impacts the efficiency of ...
Some forms of mitochondrial dysfunction induce sterile inflammation through mitochondrial DNA (mtDNA) recognition by intracellular DNA sensors. However, our understanding of the processes operating this activation is ...
Kv1.3 plays a crucial role in leukocytes, where it regulates activation and proliferation. In these cells, Kv1.3 is coexpressed with modulatory subunit KCNE4. This ancillary peptide acts as a dominant negative regulator ...
[eng] The vast and continuously increasing volume of available biomedical data produced during the last decades opens new opportunities for large-scale modeling of disease biology, facilitating a more comprehensive and ...
From the D2‐like receptors (D2,D3, D4), only D4 receptor (D4R) has been described as “promiscuous” since it can be activated both by dopamine (DA) and norepinephrine (NE) and function as a noradrenergic receptor in the ...
