Now showing items 168-187 of 315
Murillo Villuendas, Ester (Date of defense: 2023-10-20)
[eng] Polyamines are small polycationic molecules that contain amino groups and are found in all living organisms. This study is aimed at acquiring a comprehensive understanding of the diverse roles of polyamines in plants, ...
Domostegui Fernández, Ana (Date of defense: 2019-12-05)
The oncogene MYC is altered and its expression is deregulated in up to 70% of human cancers, including B cell neoplasms. Earlier studies in a mouse model of Eμ-MYC-driven B-cell lymphomas reported that oncogenic MYC relies ...
Hernández Madrigal, Miguel (Date of defense: 2022-06-17)
Tumours grow in a self-imposed hypoglycaemic microenvironment due to their exacerbated metabolic needs. To thrive in these harsh conditions, malignant cells must adapt their own metabolic routes and hijack the host nutrient ...
Ruiz-Loscertales, H. (Héctor) (Date of defense: 2017-07-17)
Los Sistemas Personalizados de Dosificación (SPD) son un sistema de reacondicionado donde el farmacéutico organiza los medicamentos de forma farmacéutica sólida que toma un determinado paciente durante una semana, siguiendo ...
Seuma Areñas, Mireia (Date of defense: 2023-01-18)
[eng] Proteins can adopt multiple conformations and material states, from soluble states to self- assemblies, such as liquid condensates or amyloids. Protein aggregation has been associated with many human diseases but how ...
Riera Armengol, Pau (Date of defense: 2020-09-23)
El càncer colorectal (CCR) és una neoplàsia molt freqüent que causa una elevada mortalitat arreu del món. Els fàrmacs més utilitzats en el seu maneig són quimioteràpics (fluoropirimidines, oxaliplatí i irinotecan), agents ...
Corpas Expósito, Rubén (Date of defense: 2016-12-22)
El aumento de la esperanza de vida poblacional que ha tenido lugar en las últimas décadas, previsiblemente conducirá a un incremento de la incidencia de enfermedades asociadas con la edad, incluyendo la demencia. La principal ...
Ballester Servera, Carme (Date of defense: 2023-10-16)
[spa] La calcificación cardiovascular (CCV) afecta a arterias y válvulas comprometiendo su normal funcionamiento y aumentando el riesgo de sufrir accidentes cardiovasculares y de desarrollar hipertrofia cardíaca e insuficiencia ...
Ramírez Corpas, Lorena (Date of defense: 2023-01-20)
[spa] Alrededor del 10% de los pacientes con cáncer colorrectal metastático (mCRC) presentan la mutación BRAF(V600E), mutación que está asociada a una peor respuesta al tratamiento estándar con agentes quimioterapéuticos ...
Avalos de León, Cindy Guadalupe (Date of defense: 2020-07-21)
Cada año, miles de personas fallecen a causa de enfermedades hepáticas en estado terminal, siendo la falta de injertos hepáticos un problema sin resolver en la práctica clínica. Para tratar de resolver esta grave situación ...
Bernat Peguera, Adrià (Date of defense: 2019-09-20)
La mayoría de los carcinomas escamosos de piel (cSCCs) se tratan con éxito mediante escisión quirúrgica. Sin embargo, el 5-8% de los casos desarrollan recurrencias, las cuales están asociadas a un crecimiento agresivo, ...
Rinaldi de Alvarenga, José Fernando (Date of defense: 2019-07-18)
Cooking made humans evolve. Cooking modified our gastrointestinal system, reducing the gut size and energy expenditure for digestion, which enabled the appearance of a more energy-dependent brain. Cooking process have ...
Monaco, Paola (Date of defense: 2022-09-23)
[eng] Rhabdomyosarcoma (RMS) is the most prevalent soft tissue sarcoma (STS) in children and adolescents. The Alveolar subtype (ARMS) is driven by PAX3-FOXO1, a fusion protein originated from a chromosomal translocation. ...
Burciaga Monge, Alma Delia (Date of defense: 2020-01-31)
Los esteroles son una familia de compuestos triterpénicos que se presentan en forma libre o conjugada, como ésteres, glicósidos y acilglicósidos de esteroles. Cada especie vegetal tiene su propio perfil cualitativo y ...
Marín-Valls, Roser (Date of defense: 2021-10-01)
Biocatalysis gained importance in the latter half of the 20th century and its application in the pharmaceutical, food and chemical industries continues to expand nowadays. Enzymes catalyze chemical reactions in a highly ...
Limón Magaña, David (Date of defense: 2017-07-21)
anostructured supramolecular hydrogels and gold nanoparticles, as two kinds of nanomaterials, were synthsized, characterized and evaluated for their potential as drug delivery systems. Two bis-imidazolium cationic ...
Guercetti, Julian (Date of defense: 2023-10-25)
[eng] The current doctoral thesis titled “Microarray Strategies for Multiplexed Immunochemical Analysis” was carried out in the context of two research projects, expecting to develop multiplexed ligand-binding assays under ...
Antolin Fontes, Albert (Date of defense: 2019-03-07)
The mitochondrial Seryl-tRNA Synthetase (SerRS2) is a member of the class II tRNA synthetase family. The mature enzyme catalyses the ligation of serine to tRNASer in mitochondria. During the process of constructing a model ...
Calatayud Robert, Sara (Date of defense: 2021-12-20)
Proteins are composed of domains, a well-defined region within a protein that constitutes a stable, independently folding, compact structural unit, and that usually performs a specific function. During protein evolution, ...
Gutierrez Prat, Núria (Date of defense: 2018-10-03)
Cells often need to respond to damaging internal and external stimuli. One of the pathways that is frequently activated by stress stimuli involves activation of the kinase p38alpha, which can phosphorylate different ...