Now showing items 285-304 of 315
Barnadas Solé, Cristina (Date of defense: 2021-02-22)
Hasta hace no muchos años la obesidad se relacionaba con un desequilibrio entre la ingesta dietética y el gasto energético. Sin embargo, esta aproximación era muy simplista y actualmente se conoce el carácter multifactorial ...
Balcells Nadal, Cristina (Date of defense: 2019-12-19)
Metastasis and drug resistance represent the two main causes of therapeutic failure in oncology. In the present dissertation, the interplay between them has been interrogated using metabolomics, systems biology and biophysical ...
Martín López, Juan (Date of defense: 2022-07-15)
The present Thesis is divided in three chapters: 1. Design and synthesis of new soluble epoxide hydrolase inhibitors (sEHI) The synthesis of new soluble epoxide hydrolase inhibitors based on ureas as the main ...
Dumaze, Anaëlle (Date of defense: 2023-11-08)
[eng] My thesis was part of a collaborative project at the interface of neuropharmacology and medicinal chemistry that aimed to better understand the neuromodulation mechanisms associated with Alzheimer’s Disease (AD). In ...
Pou Cabello, Ana (Date of defense: 2017-06-30)
Over the past decade, sphingolipids have emerged as a new class of modulators of various cell functions. Ceramide, which is the central molecule in the biosynthesis of sphingolipids and glycosphingolipids, is involved in ...
Jora, Beatrice Elena (Date of defense: 2022-10-27)
[eng] The present thesis focuses on the study and synthesis of three active principles (APIs) with therapeutic activity. Although these compounds are commercially available, their route of synthesis are very old, therefore ...
Vidal Miñano, Pedro Jesús (Date of defense: 2020-09-07)
En Ia levadura de gemación el tamaño celular en START o tamaño crítico está determinado por Ia velocidad de crecimiento en G1. Durante esta fase, Saccharomyces cerevisiae presenta una disminución de Ia relación ...
González Velasco, Lorena (Date of defense: 2021-09-14)
Non-canonical activation of p38α MAPK has been associated to cardiomyocyte death in several cardiovascular pathologies, such as myocardial ischaemia-reper- fusion injury. Unfortunately, current p38α inhibitors are mainly ...
Bouzón Arnáiz, Inés (Date of defense: 2022-11-11)
[eng] Malaria caused 241 million cases and 627,000 deaths worldwide in 2020, representing one of the biggest threats for global health nowadays. The currently available arsenal of antimalarial drugs is insufficient to ...
Lantero Escolar, Elena (Date of defense: 2020-12-11)
La malaria es una enfermedad infecciosa producida por Plasmodium, protozoo transmitido a través de la picadura de mosquitos del género Anopheles. Aunque existen tratamientos y medidas de prevención, en los países tropicales ...
Miñarro Lleonar, Marina (Date of defense: 2023-02-24)
[eng] Advances in structural and molecular biology have favoured the rational development of novel drugs thru structure-based drug design (SBDD). Particularly, computational tools have proven to be rapid and efficient tools ...
Zimmermann, Fabian (Date of defense: 2021-11-24)
The microtubule nucleator γ-tubulin ring complex (γTuRC) is essential for the function of microtubule organizing centers such as the centrosome. Since its discovery over two decades ago, γTuRC has evaded in vitro reconstitution ...
Jiménez Flores, Lizbeth Minerva (Date of defense: 2018-11-09)
Gastric cancer (GC) is one of the most common types of cancer in the Western World and accounts for over 700,000 deaths every year worldwide. The prognosis is dismal, with an average 5-year survival rate of less than 20%, ...
Morcelle Magaña, Carmen (Date of defense: 2017-09-19)
In most human cancers, the c-Myc transcription factor is deregulated and/or its levels are elevated, particularly in colorectal cancer (CRC). Earlier studies suggested a direct relationship between ribosome biogenesis and ...
Villamor Payà, Marina (Date of defense: 2021-07-08)
The Tousled like kinases 1 and 2 (TLK1 and TLK2) are evolutionarily conserved Ser/Thr kinases that are required for genome stability and normal development in numerous organisms. Both kinases contribute to histone deposition ...
Meler Marquina, Ainara (Date of defense: 2023-06-29)
[eng] Proper B cell identity demands a tight controlled genomic and epigenomic landscape at each stage of cellular differentiation during B lymphocyte development. It has been previously identified in our group that HDAC7 ...
Zamora Ramírez, William J. (Date of defense: 2019-02-22)
Lipophilicity is a key physicochemical descriptor used to understand the biological profile of (bio)organic compounds, xenobiotics and a broad variety of biochemical, pharmacological, and toxicological processes. This ...
Altay, Gizem (Date of defense: 2018-12-20)
Intestinal epithelium is highly specialized tissue organized into crypt-villus units relevant for their effective barrier function and nutrient absorption. In the crypt units reside the proliferative intestinal stem cells ...
Șandor, Alexandra Georgiana (Date of defense: 2021-12-17)
In this PhD thesis we have demonstrated that tris(triphenylphosphine)ruthenium(II) dichloride (RuCl2(PPh3)3) is a potent and versatile catalyst capable of achieving efficient different chemical transformations under microwave ...
Gómez González, Soledad (Date of defense: 2017-09-21)
Evidencias recientes han mostrado que los tumores sólidos pediátricos, incluidos el neuroblastoma y el meduloblastoma, albergan una baja cantidad de mutaciones genéticas recurrentes, pero presentan una proporción significativa ...