Ara mostrant els elements 298-315 de 315

    The role of the RPL5/RPL11/5S rRNA complex in mediating p53 levels in response to c-Myc depletion in colorectal carcinoma 

    Morcelle Magaña, Carmen (Data de defensa: 2017-09-19)

    In most human cancers, the c-Myc transcription factor is deregulated and/or its levels are elevated, particularly in colorectal cancer (CRC). Earlier studies suggested a direct relationship between ribosome biogenesis and ...

    The Tousled-like kinases and their implications in cancer and neurodevelopmental disorders 

    Villamor Payà, Marina (Data de defensa: 2021-07-08)

    The Tousled like kinases 1 and 2 (TLK1 and TLK2) are evolutionarily conserved Ser/Thr kinases that are required for genome stability and normal development in numerous organisms. Both kinases contribute to histone deposition ...

    The transcriptional regulator HDAC7 role in B cell development and associated malignancies 

    Meler Marquina, Ainara (Data de defensa: 2023-06-29)

    [eng] Proper B cell identity demands a tight controlled genomic and epigenomic landscape at each stage of cellular differentiation during B lymphocyte development. It has been previously identified in our group that HDAC7 ...

    Toward Refined Theoretical Models for the Description of Lipophilicity in Biomolecules 

    Zamora Ramírez, William J. (Data de defensa: 2019-02-22)

    Lipophilicity is a key physicochemical descriptor used to understand the biological profile of (bio)organic compounds, xenobiotics and a broad variety of biochemical, pharmacological, and toxicological processes. This ...

    Towards the development of biomimetic in vitro models of intestinal epithelium derived from intestinal organoids 

    Altay, Gizem (Data de defensa: 2018-12-20)

    Intestinal epithelium is highly specialized tissue organized into crypt-villus units relevant for their effective barrier function and nutrient absorption. In the crypt units reside the proliferative intestinal stem cells ...

    Tris(triphenylphosphine)Ruthenium(II) dichloride: a versatile catalystin the synthesis of β-, γ- and δ-lactams from trichloroacetamides and in the isomerization of protected allylamines to Z-enamines under microwave activation 

    Șandor, Alexandra Georgiana (Data de defensa: 2021-12-17)

    In this PhD thesis we have demonstrated that tris(triphenylphosphine)ruthenium(II) dichloride (RuCl2(PPh3)3) is a potent and versatile catalyst capable of achieving efficient different chemical transformations under microwave ...

    Tumores del Desarrollo, Epigenética y miRNAs 

    Gómez González, Soledad (Data de defensa: 2017-09-21)

    Evidencias recientes han mostrado que los tumores sólidos pediátricos, incluidos el neuroblastoma y el meduloblastoma, albergan una baja cantidad de mutaciones genéticas recurrentes, pero presentan una proporción significativa ...

    Uncovering the molecular and cellular mechanisms of metastatic dormancy in luminal breast cancer 

    Cejalvo Andújar, Juan Miguel (Data de defensa: 2020-01-22)

    Breast cancer (BC) is the most common cancer in women and it represents the most common cause of cancer-­‐related death in women worldwide1. Advances in early detection, prevention, risk stratification, and therapeutic ...

    Understanding the mechanisms of food intake and obesity in Down syndrome is supported by behavioral and neurochemical abnormalities 

    Fructuoso Castellar, Marta (Data de defensa: 2017-09-18)

    Obesity prevalence is higher in Down syndrome (DS) than in the general population. Beyond metabolic alterations, individuals with DS present increased impulsivity, a trait observed in obese people and in compulsive eaters ...

    Unraveling the Fundamental Aspects of Enzyme-powered Micromotors 

    Arqué Roca, Francesc Xavier (Data de defensa: 2023-01-24)

    [eng] Enzyme-powered motors are based on the micro- and nanosized particles that propel thanks to the chemical conversion of enzymes attached on their surface. Recently, these tiny devices have been applied for a plethora ...

    Unveiling the biological role of stigmasterol biosynthesis in tomato plants 

    Gutiérrez García, Laura (Data de defensa: 2019-10-31)

    In plants, the sterol biosynthetic pathway leads to the production of a complex mixture of end-products, among which β-sitosterol, stigmasterol, campesterol, and cholesterol are the most abundant ones. Stigmasterol, the ...

    Unveiling the role of DXS-Interacting (DXI) proteins in the regulation of plastidial isoprenoid biosynthesis 

    Llamas Pámanes, Ernesto (Data de defensa: 2017-09-15)

    Chloroplasts provide plants with metabolic pathways that are unique among eu- karoytes, including the methylerythritol 4-phosphate pathway (MEP) for the pro- duction of isoprenoids essential for photosynthesis and plant ...

    Unveiling the therapeutic potential of THC in endometrial cancer 

    Coll Iglesias, Laura (Data de defensa: 2022-11-23)

    [eng] Endometrial cancer represents the most common cancer arising from the uterine cavity and there is little hope for patients with recurrent or metastatic disease. Prior studies of our group reported autophagy pathway ...

    Utilidad y aplicación de diferentes técnicas (bioquímicas, proteómicas y moleculares) en la caracterización de Leishmania 

    Fernández Arévalo, Anna (Data de defensa: 2020-11-24)

    [spa] Las leishmaniosis son enfermedades causadas por el género Leishmania. Mientras que la clínica visceral se asocia al complejo L. donovani, la clínica tegumentaria puede estar producida por cualquier especie que afecte ...

    Utilització de medicaments des de l’atenció primària en el dolor crònic no oncològic 

    Viñas Bastart, Montserrat (Data de defensa: 2023-09-15)

    [cat] L’augment del consum d’analgèsics en general i d’opioides en particular és una qüestió que preocupa especialment en els països industrialitzats. L’origen del canvi en el patró de prescripció i ús d’aquests medicaments ...

    Utilización de aceites ácidos y ácidos grasos destilados en alimentación animal: caracterización de estos subproductos y repercusiones de su uso en la estabilidad oxidativa de piensos y carne de pollo 

    Varona Sánchez, Elisa (Data de defensa: 2021-01-29)

    La correcta formulación de piensos es esencial para conseguir dietas que aporten al animal niveles equilibrados de nutrientes, a la vez que se consiga una eficiencia en la producción animal mediante piensos con palatabilidad ...

    Vehiculización de aromas de uso farmacéutico y alimentario mediante tecnologías mixtas de extrusión y lecho fluido 

    Villca Pozo, Faviola (Data de defensa: 2020-09-16)

    Los aromas se definen como productos no destinados al consumo como tales, que se añaden a los alimentos o a ciertos medicamentos para darles un olor o un sabor, o para enmascarar y/o modificar su olor o sabor. Debido a la ...

    Water-in-Water Emulsions for Obtaining Enzyme-Loaded Microgels and Encapsulated Emulsions 

    Beldengrün, Yoran (Data de defensa: 2018-07-20)

    Encapsulation of enzymes into protective matrices is of interest in drug delivery or industrial processes, to control the release of the enzyme or protect it from harsh environments. We are studying the encapsulation of ...