Now showing items 210-229 of 315
Pascual Gilabert, Marta (Date of defense: 2022-11-04)
[eng] Myotonic dystrophy type 1 (DM1), one of the more complex diseases already known, is the most common and multisystemic rare neuromuscular disease among adults, without cure and limited pharmacological treatments. In ...
Vázquez Lozano, Javier (Date of defense: 2019-09-13)
Three-dimensional ligand-based virtual screening methods have been used for many years in drug discovery, with a variable success depending on different factors, such as the complexity of the target system or the suitability ...
Sostoa Pomés, Jana de (Date of defense: 2019-05-31)
Oncolytic virus (OV)-based therapies have an emerging role in the treatment of solid tumors, involving both direct cell lysis and immunogenic cell death. Nonetheless, tumor- associated stroma limits the efficacy of oncolytic ...
Garrido Charles, Aida (Date of defense: 2020-01-15)
Light-controlled manipulation of neuronal activity has transformed the field of neurobiology. Light provides temporal and spatial resolution over activation or inhibition of targeted populations of neurons, one single ...
Vivas Pradillo, Daniel (Date of defense: 2018-12-14)
Bone is a highly organised and specialised connective tissue that provides a rigid, protective and supporting framework to the body. In addition to this, bone is unique in its capacity to self-regenerate without the ...
Santacana Juncosa, Eugènia (Date of defense: 2020-10-07)
L'èxit dels agents biològics pel tractament de la malaltia inflamatòria intestinal es veu reduït pel fet que no tots els pacients responen bé al tractament i està descrit que fins a un 40% dels pacients que responen ...
Gonzales Gustavson, Eloy Anibal (Date of defense: 2018-02-16)
El agua es esencial para el sostenimiento de la vida en la tierra, por lo tanto, la calidad debe ser controlada para garantizar su uso de forma segura. Los objetivos planteados en esta tesis están orientados a la optimización ...
Delgado Martínez, Jennifer (Date of defense: 2023-07-06)
[spa] La leucemia mieloide aguda (LMA) es una enfermedad altamente heterogénea que hoy en día continúa demandando nuevos avances terapéuticos para hacer frente a su alta mortalidad. Este trabajo se ha centrado en explorar ...
Gállego Franco, Laia (Date of defense: 2017-09-15)
El caracol de consumo humano Cornu aspersum actúa como hospedador intermediario en el ciclo biológico de Brachylaima spp. albergando metacercarias libres en riñón. Su ingestión insuficientemente cocinados permitiría a las ...
Sotillo Rodríguez, Fernando (Date of defense: 2018-02-16)
Lysinuric Protein Intolerance (LPI, MIM #222700) is a rare autosomic disease caused by mutations in SLC7A7 gene. Hallmarks of LPI are malabsorption and deficient renal reabsorption of cationic amino acids, which drives a ...
Millán Nebot, Claudia Lucía (Date of defense: 2018-09-21)
Phasing X-ray data within the frame of the ARCIMBOLDO programs requires very accurate models and a sophisticated evaluation of the possible hypotheses. ARCIMBOLDO uses small fragments, that are placed with the maximum ...
Duran Corbera, Anna (Date of defense: 2022-04-22)
G protein-coupled receptors (GPCRs) are a large family of membrane proteins responsible for signaling transduction processes. Due to their roles in modulating essential physiological functions, GPCRs are classical ...
Torres Ferraz, Rosa (Date of defense: 2018-12-20)
Actualment no existeix cap medicament aprovat pel tractament de la Síndrome de l’Ovari Poliquístic (PCOS), un dels desordres endocrins més freqüent en dones en edat reproductiva, amb una prevalença creixent i que es ...
Merino Méndez, Raquel (Date of defense: 2021-12-13)
OBJETIVOS: Describir y analizar la prevalencia de la polimedicación y de la prescripción “off-label” de los pacientes con daño cerebral adquirido (DC) y con lesión medular (LM) que estaban ingresados en un hospital de ...
Arafaty, Nazanin (Date of defense: 2021-04-30)
The topic of this thesis is to investigate the polyamine metabolism during defense response in Arabidopsis thaliana. I mainly focused on the alteration of polyamine metabolism in different layers of plant immunity triggered ...
Palau de Miguel, Anna (Date of defense: 2016-11-30)
Polycomb proteins are important epigenetic regulators involved in the maintenance of stemness and differentiation. In this thesis, I focused on the role of some Polycomb Repressive Complex 1 (PRC1) components. On the one ...
Leiva Martínez, Rosana (Date of defense: 2017-09-22)
The present PhD Thesis evolves around the design, synthesis and pharmacological evaluation of novel 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors. Given that the enzyme active site includes a hydrophobic ...
Quintairos Domenech, Luis (Date of defense: 2021-07-08)
Despite advances in immunosuppression, allograft rejection and clinical outcomes remain a challenge in solid organ transplantation. Currently, the immunosuppressive treatment’s individual adjustment is guided by the ...
Farwati, Abduljalil (Date of defense: 2017-09-21)
Durante las últimas décadas, una de las principales aspiraciones de la investigación biomédica ha constituido el diagnóstico precoz de diferentes enfermedades de alta tasa de mortalidad. La posibilidad de detección en fase ...
Parilli Moser, Isabella (Date of defense: 2023-09-13)
[eng] Peanuts are the most consumed nut worldwide and are widely regarded as a convenient, tasty, and easy snack that contain a variety of nutrients and bioactive compounds that are beneficial for human health. Among these ...