Universitat de Barcelona
Now showing items 247-266 of 313
The human leukocyte antigen-G (HLA-G) is a non-classic MHC class I molecule. It is called “non-classic” because it differs from classic MHC class I molecules due to its very low amount of polymorphism and highly tissue-restricted ...
The γ-‐tubulin ring complex (γTuRC) is required to efficiently generate new microtubules (MT) in a process known as MT nucleation. In mitotic cells, MT nucleation by γTuRC occurs from the centrosome, in vicinity of the ...
Pericytes (PCs) are important regulators of the vascular development promoting vessel growth and stabilization. They have recently emerged as a therapeutic target to promote or inhibit angiogenesis. Therefore, advancing ...
Inflammatory bowel diseases (IBD) are chronic inflammatory processes that affect the gastrointestinal tract. IBD is characterized by an intestinal inflammation and epithelial cell injury leading to a poor psychosocial ...
The cell cycle is orchestrated by the periodic activation of Cyclin-dependent kinases (CDKs). The enzymatic activity of CDKs depends on their association with cyclins, however, in some cases these kinases can be activated ...
Transportome alterations have been associated with oncogenesis. The loss of human Concentrative Nucleoside Transporter 1 (hCNT1) during carcinogenesis seems to be a relatively common event in tumors and might by itself ...
Histone deposition during DNA replication, transcription and repair ensures the faithful maintenance of genetic and epigenetic information. The histone H3-H4 chaperone ASF1 participates in both replication dependent and ...
Transfer RNAs (tRNAs) are key adaptor molecules that mediate decoding of messenger RNAs (mRNAs) into proteins by complementary pairing of their anticodons with mRNA codons. tRNAs that undergo adenosine to inosine editing ...
[spa] La adolescencia es una etapa trascendental en la vida de las personas, la adquisición de hábitos saludables en ese período contribuirá a una mejor calidad de vida. La salud cardiometabólica y su relación con la salud ...
This thesis addresses three different subjects closely related. First, a phenotypic screening measuring cytotoxicity in the gastric cancer cell line HGC-27 is reported. Next, a targeted-based assay measuring the activity ...
Desde los años 90 numerosos han sido las contribuciones de la comunidad científica en aras a minimizar el impacto de los EM en la salud pública presentándose múltiples propuestas desde otras tantas perspectivas para que ...
Circadian rhythms regulate tissue physiology throughout the day in response to environmental cues. The primary entraining cue for the mammalian circadian clock is light, which is perceived by the retina and transmitted to ...
The aim of this project is to structurally characterize proteins involved in bacterial signal transduction systems by applying X-ray crystallography. Bacteria use signal transduction systems to react in response to any ...
[eng] In this thesis manuscript entitled “Single molecule electrochemical studies of photosynthetic complexes” I study the Photosystem I (PSI) protein complex to characterize fundamental processes of the PSI function. PSI ...
El estrato córneo (SC) es la capa más superficial de la epidermis. Su función es actuar como barrera, evitando la pérdida de agua y la entrada de microorganismos. El SC está formado por corneocitos rodeados por lípidos que ...
En la present Tesi Doctoral s’ha desenvolupat una metodologia sintètica per accedir a compostos policíclics complexos funcionalitzats de manera senzilla i eficaç, amb l’objectiu de poder generar a partir d’aquests un alquè ...
[eng] Concurrent or consecutive enzymatic cascade reactions have received special attention in the development of synthetic strategies for complex molecules. The advantage of these strategies is that they eliminate the ...
Esta tesis doctoral está enfocada a la investigación de nuevos agentes con potencial actividad antiinflamatoria y antitumoral mediante la inhibición de enzimas básicas para la progresión de la inflamación como la ciclooxigenasa ...
Dermatitis is a chronic inflammatory skin disease, described by intensive pruritus and eczematous lesions of skin. In most of the patients with Dermatitis, a long-lasting cycle of itch-scratch roots produces substantial ...
Chlamydomonas reinhardtii has emerged as a promising alternative host for recombinant protein expression. Despite its advantageous characteristics and low-cost production, its use is hampered by low expression levels of ...
