Ara mostrant els elements 1-10 de 32
Aledavood, Elnaz (Data de defensa: 2021-10-01)
This doctoral thesis is focused on disclosing molecular factors that regulate the functional mechanism of key targets in i) metabolic disorders, such as diabetes and obesity, and ii) tuberculosis (TB). ...
Villamor Payà, Marina (Data de defensa: 2021-07-08)
The Tousled like kinases 1 and 2 (TLK1 and TLK2) are evolutionarily conserved Ser/Thr kinases that are required for genome stability and normal development in numerous organisms. Both kinases contribute ...
Vilaplana Saiz, Marta (Data de defensa: 2021-01-22)
This thesis shows the research carried out on two specific diseases: familial hypercholesterolemia, which is included within the cardiovascular diseases group, and cancer. These diseases are the major ...
González Velasco, Lorena (Data de defensa: 2021-09-14)
Non-canonical activation of p38α MAPK has been associated to cardiomyocyte death in several cardiovascular pathologies, such as myocardial ischaemia-reper- fusion injury. Unfortunately, current p38α ...
Zimmermann, Fabian (Data de defensa: 2021-11-24)
The microtubule nucleator γ-tubulin ring complex (γTuRC) is essential for the function of microtubule organizing centers such as the centrosome. Since its discovery over two decades ago, γTuRC has evaded ...
Arafaty, Nazanin (Data de defensa: 2021-04-30)
The topic of this thesis is to investigate the polyamine metabolism during defense response in Arabidopsis thaliana. I mainly focused on the alteration of polyamine metabolism in different layers of ...
Benítez, Sandra (Data de defensa: 2021-01-13)
Receptor activator of nuclear factor kappa-β ligand (RANKL) and its receptor RANK are key mediators of bone resorption1,2. RANKL, its receptor RANK and its natural decoy receptor OPG, which is a competitive ...
Mayorgas, Aida (Data de defensa: 2021-09-08)
Inflammatory bowel disorders – such as Inflammatory Bowel Disease (IBD) – are rising worldwide. A well-known feature of IBD is dysbiosis of the gut microbiota, characterized by a significant reduction ...
Marín-Valls, Roser (Data de defensa: 2021-10-01)
Biocatalysis gained importance in the latter half of the 20th century and its application in the pharmaceutical, food and chemical industries continues to expand nowadays. Enzymes catalyze chemical ...
Scaffidi, Salvatore (Data de defensa: 2021-01-15)
Once a target is identified and characterized, the long pathway to develop a drug starts. In this process, biophysical methods have an important part to play and nowadays are firmly combined at several ...