Facultat de Farmàcia i Ciències de l'Alimentació: Recent submissions
Now showing items 21-40 of 338
Evaluación de las asociaciones entre la ingesta de (poli)fenoles y el cambio de peso y el riesgo de mortalidad: Análisis en las cohortes EPIC-PANACEA y ESMaestras
[spa] INTRODUCCIÓN: La obesidad global es un desafío de salud pública, con más de 2.500 millones de adultos con sobrepeso y 890 millones con obesidad. En Europa, el 59% de la población adulta está afectada, especialmente ...
La no iniciació dels tractaments farmacològics en la població pediàtrica
[cat] L'adherència als tractaments farmacològics pediàtrics és un repte important per a la salut pública. Aquesta tesi doctoral investiga la no iniciació dels tractaments farmacològics en pacients pediàtrics a Catalunya, ...
The influence of fatty acids, phenolic compounds, and vitamin B12 on health in an older Mediterranean population
[eng] Chronic diseases are the leading cause of death in the world. Several of these conditions are related to the cardiovascular or cognitive system whose pathophysiology is closely linked to alterations in inflammatory ...
Seguiment farmacoterapèutic de malalts crònics complexos i integració en el marc de la gestió compartida de processos
[cat] La prevalença de pacients d’edat avançada amb malalties cròniques, polifarmàcia associada i alt risc de deteriorament funcional i cognitiu ha augmentat en els últims anys. Per això, l'atenció als pacients crònics ...
Study of the components and adherence to the Mediterranean diet on functional and cognitive ageing: from dietary assessment to a metabolomic approach
[eng] Healthy dietary patterns, such as the Mediterranean diet, have been linked to reduced chronic disease risk and mortality. However, the evidence regarding the impact of healthy dietary patterns on physical and cognitive ...
Development and applications of photoswitchable ligands for G protein-coupled receptors
[eng] G protein-coupled receptors (GPCRs) modulate diverse cellular responses to the majority of neurotransmitters and hormones within the human body. They exhibit much structural and functional diversity and are responsive ...
New strategies for improving the biotechnological production of taxanes
[eng] Plant specialized metabolism is the source of a wide range of bioactive compounds, some of which with relevant pharmacological properties. Nowadays, cancer is one of the main causes of mortality worldwide, therefore, ...
Receptor Antigénico Quimérico en linfocitos T para el tratamiento del cáncer de mama HER2+
[spa] El cáncer de mama es el tumor más frecuentemente diagnosticado en mujeres y entre sus diversos subtipos, en esta tesis, nos centraremos particularmente en el cáncer de mama HER2+. Esta patología se caracteriza por ...
Involvement of Polyamines in Ribosome Biogenesis and Identification of Potential Genes Associated with Spermine Resistance in Arabidopsis thaliana
[eng] Polyamines are small polycationic molecules that contain amino groups and are found in all living organisms. This study is aimed at acquiring a comprehensive understanding of the diverse roles of polyamines in plants, ...
Azapolycyclic Building Blocks for the Synthesis of Daphniphyllum Alkaloids: Approaches toward Himalensine A and 2-Deoxymacropodumine A
[eng] Daphniphyllum alkaloids, isolated from various species of the Daphniphyllum genus, constitute a diverse family of natural products containing over 320 distinct members and featuring more than 20 unique polycyclic ...
Estructura de proteínas mitocondriales y complejos DNA-proteína
[spa] El desarrollo de mi tesis doctoral abarca el análisis estructural y en solución de dos proteínas mitocondriales: la isoforma 1 del Factor de Transcripción A Mitocondrial (TFAM) y el dominio N-terminal de la isoforma ...
Microarray Strategies for Multiplexed Immunochemical Analysis
[eng] The current doctoral thesis titled “Microarray Strategies for Multiplexed Immunochemical Analysis” was carried out in the context of two research projects, expecting to develop multiplexed ligand-binding assays under ...
Describing the role of the 40S-LARP1 complex in the synthesis of ribosomal proteins driven by oncogenic MYC
[eng] MYC dysregulation is the most common alteration in cancers, driving several cellular processes that cooperatively promote aberrant cell growth and proliferation. Among them, the induction of protein synthesis has ...
Deciphering the structure and dynamics of the vault particles
[eng] The vault particle, with a mass of 10 MDa and dimensions of 70 nm x 40 nm x 40 nm, is the largest ribonucleoprotein described in the eukaryotic kingdom. The vault shell is organized in two identical moieties, each ...
Synthesis and mode of action of photoswitchable ligands for neuromodulation
[eng] My thesis was part of a collaborative project at the interface of neuropharmacology and medicinal chemistry that aimed to better understand the neuromodulation mechanisms associated with Alzheimer’s Disease (AD). In ...
Estudio de las necesidades de información de los pacientes en la dispensación de medicamentos
[spa] INTRODUCCIÓN: Las estrategias de salud deben alentar a los pacientes y cuidadores a ser participantes activos de su propia atención (empoderamiento) y tomar decisiones informadas y razonadas (alfabetización en salud). ...
Design, synthesis and biological evaluation of novel molecules with the capacity of inducing the degradation of different proteins by direct signaling to the proteasome
[eng] In 2001, the initial hypothesis of targeted protein degradation (TPD) was born to announce the launching of a new era of therapeutics development not by inhibiting a component of ubiquitin-proteasome system as small ...
Exploring T-DNA gene mechanisms and optimizing centelloside production in Centella asiatica hairy root cultures
[eng] Plant biofactories constitute an eco-friendly alternative to chemical synthesis as they have a lower environmental impact and therefore contribute to a more sustainable future. Hairy root cultures, generated by ...
Structural insights into Vibrio cholerae ompU transcription activation
[eng] Cholera is an acute life-threatening infection caused by the bacterium Vibrio cholerae, a devastating pathogen in least developed countries, which caused six world pandemics, apart from the ongoing one. Despite current ...
Desarrollo de comprimidos bucodispersables de carbamazepina de uso pediátrico
[spa] La epilepsia afecta a alrededor de 50 millones de personas en todo el mundo según datos ofrecidos por la Organización Mundial de la Salud (OMS). Concretamente y para tener referencia de la afectación de esta enfermedad ...
