Facultat de Farmàcia i Ciències de l'Alimentació: Recent submissions
Now showing items 1-20 of 338
CPEB4 regulation of vasculogenic mimicry in liver cancer: mechanisms and therapeutic implications
[eng] BACKGROUND: Hepatocellular carcinoma (HCC) poses a significant clinical challenge due to its complex vascular abnormalities and the regulatory mechanisms underlying tumor progression. Vasculogenic mimicry (VM), a ...
Effects of Mediterranean Diet on Cardiometabolic Biomarkers in Randomized Clinical Trials: Molecular Mechanisms
[eng] Cardiovascular diseases (CVDs) remain the leading cause of death worldwide. This global burden continues to rise due to aging populations, unhealthy diets, sedentary lifestyles, and increasing rates of obesity and ...
Explorant tres segles de col·leccions de l’Institut Botànic de Barcelona: fonts de coneixement per a diversos aspectes de la botànica i de la història de la ciència
[cat] En aquesta tesi doctoral, mitjançant l’estudi dels herbaris històrics i dels materials d’arxiu de l’Institut Botànic de Barcelona (IBB), s’amplia el coneixement sobre alguns botànics vinculats a aquestes colꞏleccions ...
Nanopartículas lipídicas de Apigenina y Melatonina en farmacoterapia oncológica y ocular
[spa] Los sistemas nanoestructurados lipídicos (NLC) han surgido como una herramienta prometedora en la nanomedicina, ofreciendo una gran versatilidad para la administración dirigida de fármacos. Su biocompatibilidad, ...
The impact of soluble epoxide hydrolase inhibition and epoxyeicosatrienoic acids on early-life microglia activation and neuroinflammatory responses in the brain
[eng] Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive cognitive decline and is the most common cause of dementia worldwide. AD has a complex multifactorial aetiology influenced by ...
BODIPY-functionalized nanostructured materials for intracellular glutathione sensing and mitochondria bioimaging
[eng] In the present thesis, molecular probes and functionalized nanostructured materials were prepared for the detection and quantification of intracellular glutathione (GSH), as well as mitochondria bioimaging. For this ...
Impact of dietary inflammatory potential and (poly)phenols on cardiometabolic health
[eng] Obesity and cardiometabolic diseases (CMD) represent a growing health problem worldwide. The prevalence of CMD and metabolic syndrome (MetS) is increasing in adults and children. The early development of these ...
Innovación en la detección de Legionella y en el cultivo de bacterias exigentes
[spa] La legionelosis o enfermedad del legionario es una enfermedad infecciosa provocada por Legionella, una bacteria gramnegativa aeróbica estricta y un patógeno intracelular facultativo. Se transmite en humanos principalmente ...
Optimización del diagnóstico parasitológico de la leishmaniosis tegumentaria y caracterización de especie/s de Leishmania causantes del cuadro clínico en Cochabamba (Bolivia)
[spa] En Bolivia, la leishmaniosis tegumentaria (LT) abarca siete de los nueve departamentos, siendo uno de los países que presenta un mayor número de casos de leishmaniosis mucosa (LM) o leishmaniosis mucocutánea (LMC). ...
Study on Effects of Metformin and Transplantation of NPCs Separately and in Combination on Restores Cognitive Dysfunction and Histopathological Deficits in Mouse Model of Sporadic Alzheimer’s Disease
[eng] LOAD is a type of metabolic disorder known as type 3 diabetes. Metformin, a well-known anti-diabetic medication, has been introduced as a neuroprotective agent in recent years. On the hand, identifying the factors ...
Phenolic compounds and other constituents of extra virgin olive oil: Exploring the impact of cultivar, ripeness, malaxation, and high hydrostatic pressure
[eng] Olive oil represents a very important part of the economy of Spain and Catalonia. The value of this product, specifically extra virgin olive oil (EVOO), lies in its quality, both in terms of organoleptic and nutritional ...
The Contribution of the Polyamine Spermine to Plant Defense
[eng] Polyamines are essential in plant defense, with putrescine (Put), spermidine (Spd), and spermine (Spm) being the most abundant types. In response to various pathogens, including Pseudomonas syringae pv. tomato DC3000 ...
Prior knowledge and verification in macromolecular crystallography
[eng] Structural biology is essential for understanding the structure and dynamics of biological macromolecules, proteins, nucleic acids and their complexes, and to derive how the alterations produced in their structure ...
Characterization and prospective applications of melanin from black fungi in environmental biotechnology
[eng] Black fungi comprise a diverse group of ascomycetes characterized by their dark pigmentation due to the presence of melanin within their cells. This melanization process confers black fungi with a remarkable adaptability ...
Epigenomic and transcriptomic regulation of myeloid immunosuppression
[eng] This doctoral thesis delves into the complex mechanisms of the innate immune response, focusing on the role of myeloid cells such as monocytes and monocyte-derived dendritic cells in immunosuppression. These cells ...
Association between (poly)phenols and obesity: from the observational study to the clinical trial
[eng] (Poly)phenols from plants may help manage obesity due to their antioxidant and anti-inflammatory effects, but the exact types beneficial for obesity have yet to be clearly identified. High (poly)phenol diets may ...
Mecanismes i implicacions terapèutiques de la inhibició de l'epòxid hidrolasa soluble en la malaltia d’Alzheimer
[cat] La malaltia d'Alzheimer (MA) representa la causa més comuna de demència i és una de les malalties més prevalents en la societat, especialment a causa de l'augment de l'esperança de vida. Tanmateix, actualment, com a ...
Liposome Study of Baricitinib as a Novel Formula for Topical Treatment of Autoimmune Diseases
[eng] Autoimmune diseases are a diverse group of conditions where the immune system attacks the body's organs, affecting over 10% of the population, primarily women of working age. These diseases vary in severity and ...
Anàlisi “òmica” integrada de l’enteritis limfocítica secundària a enteropatia sensible al gluten. Descobriment de biomarcadors. Interès fisiopatològic i diagnòstic
[cat] La celiaquia es considera una malaltia d’elevada prevalença i la ingestió de gluten en pacients celiacs pot induir una gran varietat de simptomes incloent simptomatologia extraintestinal. Entre les estratègies de ...
Papel de la variabilidad viral, la expresión de RNA y la microbiota en el carcinoma asociado a la infección por el Virus del Papiloma Humano 16
[spa] El virus del papiloma humano (VPH) es el agente causal de múltiples cánceres ginecológicos, incluyendo el cáncer de vulva (VSCC). Si bien la infección por VPH es necesaria para el desarrollo de estas neoplasias, no ...
