Facultat de Farmàcia i Ciències de l'Alimentació: Recent submissions
Now showing items 241-260 of 331
Caracterització funcional de LOXL2 en el rabdomiosarcoma alveolar
El rabdomiosarcoma (RMS) és el sarcoma de parts toves més comú en nens i adolescents que representa un 3-4 % dels càncers infantils. En canvi, és molt menys freqüent en adults. Principalment consisteix en dues variants ...
Analysis of the molecular function of kazrin in endosomal trafficking
Endocytosis and endosomal trafficking are of central meaning in all eukaryotic cells. It enables cells to rapidly modify their surface exposure of signalling complexes, nutrient and ion transporters, to maintain the ...
The Role of Protein Kinase N in Gastric Cancer
Gastric cancer (GC) is one of the most common types of cancer in the Western World and accounts for over 700,000 deaths every year worldwide. The prognosis is dismal, with an average 5-year survival rate of less than 20%, ...
Dual effect of Semaphorin 4D blockade in neuroendocrine tumor malignization: from vessels to macrophages
Tumor progression is a complex conundrum of events that involve not only tumor cells, but also their surrounding microenvironment. Accounting to the natural dependency of tumors on angiogenesis, its therapeutic targeting ...
Immunoreceptor MerTK: A journey from the membrane into the nucleus of human dendritic cells
Discrimination between foreign and potentially harmful antigens, and the body’s own tissue is one of the most crucial first steps that lays at the basis of a proper immune response. Immunoreceptors are cell membrane embedded ...
Recerca i caracterització de nous "leads" per al tractament del càncer
La present tesi doctoral està enfocada al desenvolupament de noves petites molècules dirigides a diferents dianes del càncer. Els descobriments recents sobre la seqüenciació genòmica del càncer han revelat que molts dels ...
RANK signaling in mammary spontaneous tumorigenesis and tumor-stromal crosstalk
The discovery that RANK signaling mediates the protumorigenic role of progesterone in the mammary gland and its association with poor prognosis in breast cancer has opened the possibility of using RANKL inhibitors for ...
CPEB4 function in macrophages
As innate immune cells, macrophages sense endogenous and exogenous danger signals and respond orchestrating inflammatory processes. For the rapid induction and efficient resolution of inflammatory responses, macrophages ...
Molecular basis of p38a MAPK signaling
Cells often need to respond to damaging internal and external stimuli. One of the pathways that is frequently activated by stress stimuli involves activation of the kinase p38alpha, which can phosphorylate different ...
Síntesis de nuevos compuestos con potencial actividad antitumoral y/o antiinflamatoria
Esta tesis doctoral está enfocada a la investigación de nuevos agentes con potencial actividad antiinflamatoria y antitumoral mediante la inhibición de enzimas básicas para la progresión de la inflamación como la ciclooxigenasa ...
Phase Combination and its Application to the Solution of Macromolecular Structures: Developing ALIXE and SHREDDER
Phasing X-ray data within the frame of the ARCIMBOLDO programs requires very accurate models and a sophisticated evaluation of the possible hypotheses. ARCIMBOLDO uses small fragments, that are placed with the maximum ...
Molecular mechanism of dBigH1 action
INTRODUCTION: For decades it was known that many species contain embryo specific linker histone H1 variants that replace the somatic H1 during early embryogenesis. This is especially important because the early embryo ...
Water-in-Water Emulsions for Obtaining Enzyme-Loaded Microgels and Encapsulated Emulsions
Encapsulation of enzymes into protective matrices is of interest in drug delivery or industrial processes, to control the release of the enzyme or protect it from harsh environments. We are studying the encapsulation of ...
In silico molecular modelling and design of heme-containing peroxidases for industrial applications
It is widely known that the development of modern chemistry and the consequent world industrialization have improved our quality of life to unimaginable levels. However, these advances have come with a high cost, causing ...
New immunochemical approaches for Multiplexed diagnostics
The central topic of this thesis has been the study, development and validation of diverse multiplexed diagnostics platforms and techniques that can be applied to a wide range of topics, from environmental monitoring to ...
Biomedical studies of human adenosine deaminase acting on transfer RNA and related therapeutic strategies
Adenosine deaminase acting on transfer RNA (ADAT) is a human heterodimeric enzyme that catalyzes the deamination of adenosine (A) to inosine (I) at the first position of the anticodon of transfer RNAs (tRNAs) (position 34, ...
Evolution of I34 modifications in tRNAs and their role in proteome composition
Inosine is a guanosine analogue that when is found at the wobble position of the tRNAs (I34) expands its codon recognition capability. Inosine can wobble pair with cytosine, adenosine and uridine. Because inosine is not ...
Respuesta innata de los adipocitos en el metabolismo de fragmentos de 3C en el tejido adiposo blanco e influencia de la insulina
Se ha observado en nuestro grupo de investigación que tanto las células 3T3L1 como el tejido adiposo blanco in vivo son capaces de liberar, a partir de la glucosa, grandes cantidades de lactato en condiciones aeróbicas y ...
Descripción de un nuevo tipo de vesícula de membrana externa en bacterias gramnegativas: implicaciones en el contenido de DNA y RNA
En la presente Tesis Doctoral se presenta la descripción y caracterización de un nuevo tipo de vesícula de membrana externa (MV) en bacterias gramnegativas, hallada tanto en cepas ambientales como en cepas patógenas. Para ...
Estudio de los alcaloides de las Amaryllidaceae como fuente de nuevas moléculas bioactivas
Amaryllidaceae es una familia de plantas que contiene un grupo exclusivo de alcaloides a los que se ha dado considerable atención teniendo en cuenta sus características estructurales y sus actividades biológicas, siendo ...
