Facultat de Farmàcia i Ciències de l'Alimentació: Recent submissions
Now showing items 261-280 of 331
Role of the human Concentrative Nucleoside Transporter 1 (hCNT1) in oncogenesis
Transportome alterations have been associated with oncogenesis. The loss of human Concentrative Nucleoside Transporter 1 (hCNT1) during carcinogenesis seems to be a relatively common event in tumors and might by itself ...
Improving islet-graft revascularization
El trasplante de islotes ha sido reconocido como una prometedora opción de tratamiento de la diabetes tipo 1 (DT1) tras la introducción del protocolo de Edmonton, el cual enfatiza el requerimiento de un adecuado número de ...
Strategies to improve Chlamydomonas reinhardtii as a recombinant protein host: from a small growth factor to a complex monoclonal antibody production
Chlamydomonas reinhardtii has emerged as a promising alternative host for recombinant protein expression. Despite its advantageous characteristics and low-cost production, its use is hampered by low expression levels of ...
Role of the Tousled like kinases in maintaining genome and epigenome stability
Histone deposition during DNA replication, transcription and repair ensures the faithful maintenance of genetic and epigenetic information. The histone H3-H4 chaperone ASF1 participates in both replication dependent and ...
Analysis of the molecular bases that mediate the interplay between Multisubunit Tethering Complexes and P4-ATPases
Vesicle trafficking is fundamental to distribute correctly lipids and proteins among cellular compartments. A complex network of interconnected pathways transport vesicles between organelles to satisfy the cellular demand. ...
Funció del factor d'elongació eEF1A2 en plasticitat sinàptica
La plasticitat sinàptica és la capacitat que té el sistema nerviós de canviar la seva estructura i funcionament al llarg del desenvolupament. En processos d’aprenentatge, es formen noves espines dendrítiques que permetran ...
Effect and Metabolism of lignans on gut microbiota and their impact on health
The World Health Organization (WHO) 1 says that CVDs are number one cause of death globally. An estimated 17.7 million people died from CVDs in 2015, representing 31% of all global deaths. Over three quarters of CVD deaths ...
Optimización de métodos para el estudio del riesgo asociado a la contaminación fecal del agua y alimentos: cuantificación de patógenos y del riesgo de infecciones virales y análisis metagenómico de virus asociados a hepatitis
El agua es esencial para el sostenimiento de la vida en la tierra, por lo tanto, la calidad debe ser controlada para garantizar su uso de forma segura. Los objetivos planteados en esta tesis están orientados a la optimización ...
Regulación de la producción de taxanos y otros metabolitos secundarios en cultivos de células y órganos vegetales
Los cultivos celulares en suspensión representan un excelente herramienta biotecnológica para la producción de compuestos bioactivos empleados en la industria farmacéutica, cosmética y química. Entre éstos, los metabolitos ...
Análisis transcriptómico para identificar genes biomarcadores del estado nutricional en la dorada (Sparus aurata): efecto de la sobreexpresión hepática de SREBP-1a
La acuicultura es una importante actividad económica vinculada a la producción de alimentos que se encuentra en etapa de expansión. Sin embargo, la producción de especies carnívoras como la dorada (Sparus aurata) presenta ...
Structure, Dynamics and Complex Formation of Eukaryotic Transcriptional Regulators
The common scope of this thesis is the application of structural biology and biophysics to obtain novel data on nuclear proteins that modulate DNA transcription. The proper regulation and functioning of these elements are ...
Pathophysiology of immune-related complications in Lysinuric Protein Intolerance
Lysinuric Protein Intolerance (LPI, MIM #222700) is a rare autosomic disease caused by mutations in SLC7A7 gene. Hallmarks of LPI are malabsorption and deficient renal reabsorption of cationic amino acids, which drives a ...
The role of RIPK1 in TNF-induced cell death in intestinal epithelial cells
Inflammatory bowel diseases (IBD) are chronic inflammatory processes that affect the gastrointestinal tract. IBD is characterized by an intestinal inflammation and epithelial cell injury leading to a poor psychosocial ...
Investigating Glial Contributions During Parkinson’s Disease Pathogenesis Using Patient-Specific iPSC-Derived Cells
La malaltia de Parkinson (PD) s'associa amb la degeneració de les neurones dopaminèrgiques del mesencèfal ventral (vmDA) i l'acumulació d'inclusions citoplasmàtiques, els cossos de Lewy, compostos principalment per la α ...
Nanostructured systems for therapeutic treatment of neurodegenerative diseases = Sistemas nanoestructurados en el abordaje terapéutico de enfermedades neurodegenerativas
The incidence of neurodegenerative diseases, such as Alzheimer's disease, increases every year due to population aging. Therefore, the development of new therapeutic strategies, such as biodegradable nanostructured systems ...
Estudios galénicos de nuevas terapias analgésicas tópicas
El dolor es una de las afecciones más referidas en la consulta clínica y en su tratamiento se utilizan distintos medicamentos según su intensidad, duración, etiología o enfermedad subyacente. La terapia analgésica comprende ...
Estudi de dos mecanismes moleculars implicats en l’expressió local d’mRNAs en plasticitat sinàptica
La regulació local de la síntesi proteica permet a la neurona respondre ràpidament a senyals sinàptiques, és un element fonamental de la plasticitat sinàptica i està alterat en moltes patologies neuronals. La síntesi de ...
Role of HDAC11 in muscle cell differentiation and regeneration = Paper de HDAC11 en la diferenciació i regeneració musculars
HDAC11 is the newest member of the histone deacetylase (HDAC) family and one of the less studied. Its expression was described to be enriched in skeletal muscle tissues from the first moment of its discovery, yet now after ...
The effect of inhibition of nucleotide synthesis on ribosome biogenesis and the induction of p53
Ribosome biogenesis is one of the most energy consuming anabolic processes in a cell, required for the generation of the translational machinery to grow and proliferate. Moreover, this process necessitates the coordination ...
Advancing induced pluripotent stem cell (iPSC) technology by assessing genetic instability and immune response
Induced pluripotent stem cells (iPSC) can be made from adult somatic cells by reprogramming them with Oct4, Sox2, Klf4 and c-Myc. IPSC have given rise to a new technology to study and treat human disease (Takahashi et al., ...
