Facultat de Farmàcia i Ciències de l'Alimentació: Recent submissions
Now showing items 321-331 of 331
New biotechnological systems for the research on aryltetralin lignans in Linum album
Linum album is an herbaceous plant with medical interest due to its content of podophyllotoxin (PTOX), an aryltetralin lignan with cytotoxic activity. The study of biotechnological alternatives has generated big interest. ...
Regulation of actomyosin contractility by p110α P13-kinase in sprouting angiogenesis
Class IA PI3K (PI3K) functions have been widely investigated over the last two decades. PI3K signalling is located at the crossroads of many cell surface receptors sending signals to coordinate multiple cellular functions ...
Molecular Self-Assembly for the preparation of novel nanostructured materials
In this thesis, the phase behavior in water of a technical grade diglycerol-based surfactant (C41V) and a group of dyes (Quinaldine Red, Pyronin Y, N-Alkylthiacarbocyanines, Oxacarbocyanines, Pinacyanol and Alcian Blue) ...
Structural studies of recombinant TGIF1 and FBP28 WW domains using NMR and peptide ligation strategies
The present thesis is divided in three different but related projects. In the first project, the interaction between TGIF1 and SMAD proteins is investigated. TGIF1 is a transcriptional suppressor that prevents the gene ...
Polycomb Repressive Complex 1 functions in differentiation and myelodysplastic syndromes
Polycomb proteins are important epigenetic regulators involved in the maintenance of stemness and differentiation. In this thesis, I focused on the role of some Polycomb Repressive Complex 1 (PRC1) components. On the one ...
Efectos de la hipercolesterolemia sobre monocitos/macrófagos y la inmunidad innata
La enfermedad cardiovascular sigue siendo la principal causa de morbilidad y mortalidad en todo el mundo. La inmensa mayoría de los eventos cardiovasculares incluyendo los síndromes coronarios y accidente cerebrovascular ...
Structure and biophysical studies of mitochondrial Transcription Factor A in complex with DNA
The mitochondrial transcription factor A, TFAM, has a dual function in the organelle: it activates mitochondrial DNA transcription by binding to the HSP and LSP promoters, while in higher concentrations compacts the mtDNA. ...
Formación y caracterización de nanosistemas terapéuticos con alginato
El alginato es un polímero aniónico ampliamente utilizado en aplicaciones farmacéuticas y biomédicas, debido a sus propiedades características como son la ausencia de toxicidad, biodegradabilidad, fácil disponibilidad, ...
Mecanismos de neuroprotección mediante la modulación de SIRT1
El aumento de la esperanza de vida poblacional que ha tenido lugar en las últimas décadas, previsiblemente conducirá a un incremento de la incidencia de enfermedades asociadas con la edad, incluyendo la demencia. La principal ...
Impacto de los factores de riesgo cardiovascular en las células madre de tejido adiposo
Las enfermedades cardiovasculares se desarrollan como consecuencia de la interacción entre factores genéticos y ambientales. Los factores de riesgo cardiovascular son una serie de condiciones que favorecen la aparición de ...
Regulation of amino acid catabolism in rats fed diets with different protein content
Current lifestyle with high-energy diets and characterized by sedentary is triggering an alarming growth in obesity. Obesity along with metabolic syndrome- related co-morbidities (i.e. insulin resistance, atherosclerosis, ...
