Facultat de Farmàcia i Ciències de l'Alimentació: Envíos recientes
Mostrando ítems 21-40 de 331
Receptor Antigénico Quimérico en linfocitos T para el tratamiento del cáncer de mama HER2+
[spa] El cáncer de mama es el tumor más frecuentemente diagnosticado en mujeres y entre sus diversos subtipos, en esta tesis, nos centraremos particularmente en el cáncer de mama HER2+. Esta patología se caracteriza por ...
Involvement of Polyamines in Ribosome Biogenesis and Identification of Potential Genes Associated with Spermine Resistance in Arabidopsis thaliana
[eng] Polyamines are small polycationic molecules that contain amino groups and are found in all living organisms. This study is aimed at acquiring a comprehensive understanding of the diverse roles of polyamines in plants, ...
Azapolycyclic Building Blocks for the Synthesis of Daphniphyllum Alkaloids: Approaches toward Himalensine A and 2-Deoxymacropodumine A
[eng] Daphniphyllum alkaloids, isolated from various species of the Daphniphyllum genus, constitute a diverse family of natural products containing over 320 distinct members and featuring more than 20 unique polycyclic ...
Estructura de proteínas mitocondriales y complejos DNA-proteína
[spa] El desarrollo de mi tesis doctoral abarca el análisis estructural y en solución de dos proteínas mitocondriales: la isoforma 1 del Factor de Transcripción A Mitocondrial (TFAM) y el dominio N-terminal de la isoforma ...
Microarray Strategies for Multiplexed Immunochemical Analysis
[eng] The current doctoral thesis titled “Microarray Strategies for Multiplexed Immunochemical Analysis” was carried out in the context of two research projects, expecting to develop multiplexed ligand-binding assays under ...
Describing the role of the 40S-LARP1 complex in the synthesis of ribosomal proteins driven by oncogenic MYC
[eng] MYC dysregulation is the most common alteration in cancers, driving several cellular processes that cooperatively promote aberrant cell growth and proliferation. Among them, the induction of protein synthesis has ...
Deciphering the structure and dynamics of the vault particles
[eng] The vault particle, with a mass of 10 MDa and dimensions of 70 nm x 40 nm x 40 nm, is the largest ribonucleoprotein described in the eukaryotic kingdom. The vault shell is organized in two identical moieties, each ...
Synthesis and mode of action of photoswitchable ligands for neuromodulation
[eng] My thesis was part of a collaborative project at the interface of neuropharmacology and medicinal chemistry that aimed to better understand the neuromodulation mechanisms associated with Alzheimer’s Disease (AD). In ...
Estudio de las necesidades de información de los pacientes en la dispensación de medicamentos
[spa] INTRODUCCIÓN: Las estrategias de salud deben alentar a los pacientes y cuidadores a ser participantes activos de su propia atención (empoderamiento) y tomar decisiones informadas y razonadas (alfabetización en salud). ...
Design, synthesis and biological evaluation of novel molecules with the capacity of inducing the degradation of different proteins by direct signaling to the proteasome
[eng] In 2001, the initial hypothesis of targeted protein degradation (TPD) was born to announce the launching of a new era of therapeutics development not by inhibiting a component of ubiquitin-proteasome system as small ...
Exploring T-DNA gene mechanisms and optimizing centelloside production in Centella asiatica hairy root cultures
[eng] Plant biofactories constitute an eco-friendly alternative to chemical synthesis as they have a lower environmental impact and therefore contribute to a more sustainable future. Hairy root cultures, generated by ...
Structural insights into Vibrio cholerae ompU transcription activation
[eng] Cholera is an acute life-threatening infection caused by the bacterium Vibrio cholerae, a devastating pathogen in least developed countries, which caused six world pandemics, apart from the ongoing one. Despite current ...
Desarrollo de comprimidos bucodispersables de carbamazepina de uso pediátrico
[spa] La epilepsia afecta a alrededor de 50 millones de personas en todo el mundo según datos ofrecidos por la Organización Mundial de la Salud (OMS). Concretamente y para tener referencia de la afectación de esta enfermedad ...
Potential health benefits from peanut and peanut butter-derived bioactive compounds and microbiota metabolites
[eng] Peanuts are the most consumed nut worldwide and are widely regarded as a convenient, tasty, and easy snack that contain a variety of nutrients and bioactive compounds that are beneficial for human health. Among these ...
A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance
[eng] Nuclear receptors (NRs) are a superfamily of ligand-activated transcription factors that function as biological sensors to regulate gene expression in a timeand tissue-specific and manner. The coordinated actions ...
Mecanismos de remodelado y calcificación cardiovascular: papel del receptor nuclear NOR-1 y la LOX
[spa] La calcificación cardiovascular (CCV) afecta a arterias y válvulas comprometiendo su normal funcionamiento y aumentando el riesgo de sufrir accidentes cardiovasculares y de desarrollar hipertrofia cardíaca e insuficiencia ...
Molecular segregation at multiple scales in perylene-based systems for the preparation advanced materials
[eng] This thesis addresses molecular segregation in perylene-based systems, including lyotropic chromonic liquid crystals and water-in-water emulsions. These systems offer several advantages compared to conventional ...
Salud cardiometabólica y estrés oxidativo en adolescentes del programa Salud Integral
[spa] La adolescencia es una etapa trascendental en la vida de las personas, la adquisición de hábitos saludables en ese período contribuirá a una mejor calidad de vida. La salud cardiometabólica y su relación con la salud ...
Utilització de medicaments des de l’atenció primària en el dolor crònic no oncològic
[cat] L’augment del consum d’analgèsics en general i d’opioides en particular és una qüestió que preocupa especialment en els països industrialitzats. L’origen del canvi en el patró de prescripció i ús d’aquests medicaments ...
Structural studies on Porphyromonas gingivalis proteins
[eng] We investigated the structure function relationship of PorX by combined biophysical experiments and enzymatic assays. As a regulator of the type 9 secretion system (T9SS) of the human pathogen Porphyromonas gingivalis ...
