Browsing Facultat de Medicina i Ciències de la Salut by Subject "577"

Caracterització de l’activitat immunomoduladora de C4BP(β-). Mecanismes moleculars i eficàcia terapèutica en processos immune-inflamatoris

Serrano Santacruz, Inmaculada (Date of defense: 2022-06-23)

[cat] Les característiques immunomoduladores induïdes per la proteïna plasmàtica humana C4BP(β-) en el model in vitro de Mo-DCs inflamatòries li confereixen potencial terapèutic per al restabliment de la tolerància ...

CPEB4-Driven adipocyte reprogramming is required for adipogenesis and pathological inflammation

Pell Vidal, Núria (Date of defense: 2020-11-19)

Obesity is reaching pandemic dimensions and is an established instigator of many diseases, such as non alcoholic fatty liver disease, the most prevalent liver disease worldwide. Most studies in this regard have been focused ...

Deep Learning System for the Automatic Classification of Normal and Dysplastic Peripheral Blood Cells as a Support Tool for the Diagnosis

Acevedo Lipes, Andrea Milena (Date of defense: 2021-03-09)

Clinical pathologists identify visually many morphological features to characterize the different normal cells, as well as the abnormal cell types whose presence in peripheral blood is the evidence of serious diseases. ...

Development of a Safer and More Standardized Cell Therapy for Huntington’s Disease using Isolated Stem Cell-Derived Striatal Neuroblast Subpopulations

Molina Ruiz, Francisco Jose (Date of defense: 2024-07-19)

[eng] Neurodegenerative diseases (NDs) are characterized by a selective and irreversible loss of neurons in a specific brain area. NDs are incurable and debilitating, becoming the greatest unmet clinical need of our time. ...

Endothelial Mitofusin 2 deficiency improves systemic metabolic health and delays age-associated decline

Chivite Araiz, Íñigo (Date of defense: 2020-01-24)

Blood vessels distribute nutrients and oxygen to every single cell in the body. Endothelial cells define the vessel wall, and thus they are ideally located to crucially modulate nutrient availability and act as metabolic ...

Expression and variation of lymphocyte scavenger receptors in inflammatory diseases and cancer

Casadó Llombart, Sergi (Date of defense: 2021-12-14)

The immune system comprises cellular and humoral components that protect the organism against external and internal aggressions, such as pathogens and cancer. Therefore, it can distinguish healthy, self structures from ...

Fisiopatología de modelos murinos de α-sinucleína y enfermedad de Parkinson

Juárez-Escoto, Elena (Date of defense: 2022-07-01)

[spa] La enfermedad de Parkinson (EP) es la segunda enfermedad neurodegenerativa más común, afectando al 1 % de la población de más de 60 años. La EP se caracteriza por síntomas motores como el temblor en reposo, la ...

Homólogos de moléculas co-señalizadoras codificadas por herpesvirus

Poblador Bonet, Francesc (Date of defense: 2022-12-22)

[spa] Los virus de ADN de gran tamaño, como son los herpesvirus, contienen una gran cantidad de material genético aun sin caracterizar. Estos virus han desarrollado múltiples estrategias que les permiten evadir la acción ...

Mechanical stress in curved epithelia of designed size and shape

Marín Llauradó, Ariadna (Date of defense: 2022-01-27)

GENERAL AIM: The general aim of this thesis is to understand how mechanical stress depends on pressure, size and shape in fluid-filled curved epithelial sheets. SPECIFIC AIMS: This general aim can be divided ...

Mitochondrial and autophagic alterations in human-derived cell models of Parkinson's disease related to LRRK2 (G2019S) and GBA (N370S) mutations

Juárez Flores, Diana Luz (Date of defense: 2019-07-24)

Parkinson's disease (PD) is the second most common neurodegenerative disease, and the most common movement disorder in the world population. In most cases its aetiology is still unknown, however, mitochondrial alterations ...

Neuromodulation interventions and EEG biomarkers for executive function in healthy and clinical populations

Dubreuil Vall, Laura (Date of defense: 2020-10-28)

[eng] Executive function is defined as a subset of high-order cognitive functions (including working memory, inhibition, initiation and monitoring) that sustain adaptive goal-directed behavior and thought, and that are ...

Noves metodologies per al tractament de bacteris creixent en forma de biofilm

Blanco-Cabra, Núria (Date of defense: 2021-04-16)

Les infeccions bacterianes han esdevingut un greu problema a escala mundial per culpa del mal ús que hom ha fet dels antibiòtics. L’adquisició de resistències als antimicrobians s’ha accelerat i cada cop hi ha més bacteris ...

Papel de la vinculina en la migración nuclear intercinética durante el desarrollo del tubo neural de pollo

Ochoa Alcalá, Andrea (Date of defense: 2020-10-16)

[spa] El citoesqueleto de actina es un componente esencial de las células eucariotas que tiene un importante papel en muchas funciones biológicas básicas como el mantenimiento de la morfología, la migración, el tráfico ...

Pèptids sintètics i proteïnes amb modificacions post-traduccionals per a la detecció de biomarcadors en l’artritis reumatoide

Garcia Moreno, Cristina (Date of defense: 2023-03-10)

[cat] HIPÒTESI: Els pacients d’AR presenten diferents tipus d’autoanticossos contra proteïnes/pèptids modificats (AMPA) que són útils com a biomarcadors serològics en el diagnòstic de la malaltia. No obstant, el diagnòstic ...

Plasma membrane mechanosensing upon stretch-induced topography remodelling

Quiroga Álvarez, Xarxa (Date of defense: 2021-06-23)

Five years ago, I started walking this path that now seems like an entire life. Although everyone around tried to explain how this would feel, none of their explanations could have match what it has been in the end. And ...

RANK-RANKL signaling in breast cancer. Therapeutic applications of RANKL inhibition in breast cancer

Ciscar García, Marina (Date of defense: 2022-10-03)

[spa] Durante el proyecto de tesis se han realizado dos proyectos: Por un lado, se ha investigado la biología de la vía de señalización de RANK en adenocarcinomas de mama humanos. Además, se han investigado las implicaciones ...

Study of the role of cell-matrix force transmission in naive to primed pluripotency transition in mouse embryonic stem cells

Viswandha Venkata Naga Sai, Srivatsava (Date of defense: 2024-03-07)

[eng] “Doing the right thing, at the right time, to the right extent, in the right manner, and for the right purpose”. This isn’t a shoddy attempt at virtue signalling by invoking Aristotle. It rather is my philosophical ...

Transcriptional and epigenetic events underpinning the peptide-MHC-nanoparticle-induced transdifferentiation of T-follicular helper cells into T-regulatory type 1 cells in vivo

Garnica Caparrós, Josep (Date of defense: 2022-11-10)

[spa] Descripción de los eventos transcriptómicos y epigenéticos que tienen lugar en la diferenciación de TFH a TR1 mediada por el tratamiento con nanopartículas decoradas con complejos péptido-MHC, mediante estudios tanto ...

Uncovering the elements that regulate IKKalpha function in response to DNA damage

Alonso Martínez de Marañón, Josune (Date of defense: 2022-12-01)

[spa] La terapia actual contra la mayoría de los cánceres está basada en el uso de agentes que dañan el ADN, como la quimioterapia o la radioterapia, que erradican las células tumorales proliferantes. Desafortunadamente, ...