Browsing Facultat de Medicina i Ciències de la Salut by Subject "577"

Caracterització de l’activitat immunomoduladora de C4BP(β-). Mecanismes moleculars i eficàcia terapèutica en processos immune-inflamatoris

Serrano Santacruz, Inmaculada (Date of defense: 2022-06-23)

[cat] Les característiques immunomoduladores induïdes per la proteïna plasmàtica humana C4BP(β-) en el model in vitro de Mo-DCs inflamatòries li confereixen potencial terapèutic per al restabliment de la tolerància ...

Cellular and animal models of antibody-mediated encephalitis: from pathogenesis to novel therapeutics

Maudes, Estibaliz (Date of defense: 2024-09-05)

[eng] BACKGROUND: Antibody-mediated encephalitides represent a novel category of brain inflammatory disorders mediated by antibodies targeting neural cell- surface proteins. The most prevalent form is anti-N-methyl-D-aspartate ...

CPEB4-Driven adipocyte reprogramming is required for adipogenesis and pathological inflammation

Pell Vidal, Núria (Date of defense: 2020-11-19)

Obesity is reaching pandemic dimensions and is an established instigator of many diseases, such as non alcoholic fatty liver disease, the most prevalent liver disease worldwide. Most studies in this regard have been focused ...

Deciphering the dual role of Sirtuin

Castelló García, José Manuel (Date of defense: 2024-09-27)

[eng] OBJECTIVES: Class IV sirtuins are dual sirtuins that possess deacetylation and ADP-ribosylation activities. The main objective of this PhD was to study of sirtuin duality. Specifically, we focused our attention ...

Deep Learning System for the Automatic Classification of Normal and Dysplastic Peripheral Blood Cells as a Support Tool for the Diagnosis

Acevedo Lipes, Andrea Milena (Date of defense: 2021-03-09)

Clinical pathologists identify visually many morphological features to characterize the different normal cells, as well as the abnormal cell types whose presence in peripheral blood is the evidence of serious diseases. ...

Development of a Safer and More Standardized Cell Therapy for Huntington’s Disease using Isolated Stem Cell-Derived Striatal Neuroblast Subpopulations

Molina Ruiz, Francisco Jose (Date of defense: 2024-07-19)

[eng] Neurodegenerative diseases (NDs) are characterized by a selective and irreversible loss of neurons in a specific brain area. NDs are incurable and debilitating, becoming the greatest unmet clinical need of our time. ...

Endothelial Mitofusin 2 deficiency improves systemic metabolic health and delays age-associated decline

Chivite Araiz, Íñigo (Date of defense: 2020-01-24)

Blood vessels distribute nutrients and oxygen to every single cell in the body. Endothelial cells define the vessel wall, and thus they are ideally located to crucially modulate nutrient availability and act as metabolic ...

Exploiting hPSCs-derived kidney organoids to study the mechanobiology of nephrogenesis

Nauryzgaliyeva, Zarina (Date of defense: 2024-11-08)

[eng] The isolation and generation of human pluripotent stem cells (hPSCs) has allowed research in human organogenesis to excel, by allowing the reproduction of the fundamental principles of tissue morphogenesis in vitro. ...

Expression and variation of lymphocyte scavenger receptors in inflammatory diseases and cancer

Casadó Llombart, Sergi (Date of defense: 2021-12-14)

The immune system comprises cellular and humoral components that protect the organism against external and internal aggressions, such as pathogens and cancer. Therefore, it can distinguish healthy, self structures from ...

Fisiopatología de modelos murinos de α-sinucleína y enfermedad de Parkinson

Juárez-Escoto, Elena (Date of defense: 2022-07-01)

[spa] La enfermedad de Parkinson (EP) es la segunda enfermedad neurodegenerativa más común, afectando al 1 % de la población de más de 60 años. La EP se caracteriza por síntomas motores como el temblor en reposo, la ...

Homólogos de moléculas co-señalizadoras codificadas por herpesvirus

Poblador Bonet, Francesc (Date of defense: 2022-12-22)

[spa] Los virus de ADN de gran tamaño, como son los herpesvirus, contienen una gran cantidad de material genético aun sin caracterizar. Estos virus han desarrollado múltiples estrategias que les permiten evadir la acción ...

Influencia de AURKA, SPARC, TWIST1 y PRRX1 en el melanoma desde la molécula al paciente

Ferreres Riera, Jose Ramon (Date of defense: 2024-10-04)

[spa] INTRODUCCIÓN: El melanoma cutáneo es el cáncer más agresivo de piel A pesar de que los nuevos tratamientos como la inmunoterapia o las terapias dirigidas a inhibidores de BRAF permiten aumentar la supervivència ...

Mechanical stress in curved epithelia of designed size and shape

Marín Llauradó, Ariadna (Date of defense: 2022-01-27)

GENERAL AIM: The general aim of this thesis is to understand how mechanical stress depends on pressure, size and shape in fluid-filled curved epithelial sheets. SPECIFIC AIMS: This general aim can be divided ...

Mitochondrial and autophagic alterations in human-derived cell models of Parkinson's disease related to LRRK2 (G2019S) and GBA (N370S) mutations

Juárez Flores, Diana Luz (Date of defense: 2019-07-24)

Parkinson's disease (PD) is the second most common neurodegenerative disease, and the most common movement disorder in the world population. In most cases its aetiology is still unknown, however, mitochondrial alterations ...

Neuromodulation interventions and EEG biomarkers for executive function in healthy and clinical populations

Dubreuil Vall, Laura (Date of defense: 2020-10-28)

[eng] Executive function is defined as a subset of high-order cognitive functions (including working memory, inhibition, initiation and monitoring) that sustain adaptive goal-directed behavior and thought, and that are ...

Novel carbon-based nanoscale therapeutics for the modulation of macrophages in liver inflammation, fibrosis, and regeneration

Moreno Lanceta, Alazne (Date of defense: 2024-09-20)

[eng] INTRODUCTION: Chronic liver disease (CHD) is the consequence of prolonged liver damage and is characterized by a process of inflammation and fibrosis in the liver, which causes about 2 million deaths per year. It can ...