Facultat de Medicina i Ciències de la Salut: Recent submissions
Now showing items 261-280 of 403
Advanced physiomimetic models for in vitro studies on respiratory diseases
[spa] Las células se encuentran en un entorno concreto, específico para la función de cada órgano. En el caso de los pulmones, la matriz extracelular ha de tener unas propiedades físicas que les permitan soportar los ...
Fisiopatología de modelos murinos de α-sinucleína y enfermedad de Parkinson
[spa] La enfermedad de Parkinson (EP) es la segunda enfermedad neurodegenerativa más común, afectando al 1 % de la población de más de 60 años. La EP se caracteriza por síntomas motores como el temblor en reposo, la ...
Unraveling potential disease modifiers of myotonic dystrophy type 1
[spa] La distrofia miotónica tipo 1 (DM1) es un trastorno multisistémico, progresivo y no tratable con una expansión CTG en el gen DMPK que es la base de la patología. La compleja naturaleza multisistémica de la DM1 ...
NMDA receptor mutations associated with neurodevelopmental disorders: pathophysiological impact and personalized pharmacotherapy
[spa] Los receptores ionotrópicos de tipo N-metil-D-aspartato (NMDAR) son canales iónicos activados por glutamato que juegan un papel clave en la fisiología neuronal. Los avances en la secuenciación masiva han identificado ...
Regulation of the microenvironment and chemoresistance in liver therapy
[eng] Hepatocellular carcinoma (HCC) is the most common liver cancer and currently the fourth cause of cancer-related death. Since its appearance, the multityrosine kinase inhibitor (MKI) sorafenib has been the standard ...
Microglial implication in Parkinson's Disease: studying functional and morphological changes occurring in LRRK2 microglia during PD pathophysiology using a stem cell derived human model
[eng] Parkinson’s disease (PD) is an incurable neurodegenerative disease characterized by the loss of neuromelanin (NM)-containing dopamine neurons in Substantia Nigra pars compacta (SNpc) and accumulation of insoluble ...
La microbiota intestinal en individuos infectados por el virus de la inmunodeficiencia humana tipo-1
[spa] Cada vez más, las evidencias sobre como la microbiota influye en la eficacia de las vacunas, se acumulan. Algunos trabajos sugieren que, existe una relación directa entre presentar una alta diversidad en la MI y una ...
Identification and characterization of cystinuria modulating genes: L-Ergothioneine as a potential treatment for preventing cystine lithiasis
[eng] Cystinuria, with a worldwide prevalence estimated at 1:7000, is a rare inherited disease characterized by urine hyperexcretion of cystine and dibasic amino acids. Its clinical manifestation is cystine lithiasis in ...
Prevalence of silent breast cancer in autopsy specimens: study of the diseases held by image-guided biopsies
[eng] Breast cancer epidemiological patterns vary in European countries, presenting different incidence rates (49-148 new cases per 100,000 women) with a narrow but still variable range of mortality (15-36 new cases per ...
Investigations in animal models of anti-NMDAR encephalitis
[eng] BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a neuronal antibody-mediated disease that associates with prominent neuropsychiatric symptoms and predominantly affects women of childbearing ...
Automatic recognition of different types of acute leukaemia using peripheral blood cell images
[eng] Clinical pathologists have learned to identify morphological qualitative features to characterise the different normal cells, as well as the abnormal cell types whose presence in peripheral blood is the evidence of ...
Impact of cancer cell plasticity on tumor immune microenvironment and immunotherapy response
[spa] La mayoría de los carcinomas escamosos de piel (cSCCs) se tratan con éxito mediante escisión quirúrgica. Sin embargo, el 5-8% de los casos desarrollan recurrencias, las cuales están asociadas a un crecimiento ...
Role of the NADPH oxidase NOX4 in hepatocyte proliferation
[spa] La familia de las NADPH oxidasas ha emergido en los últimos años como una importante fuente de producción de radicales libres de oxígeno (ROS), los cuáles juegan un papel fundamental en situaciones fisiológicas y ...
Implicación de la proteína C-reactiva monomérica en el desarrollo de demencia de tipo Alzheimer: Modelo experimental y posibles terapias
[spa] La neuroinflamación sostenida es un factor de riesgo de enfermedades relacionadas con la edad, incluidas las lesiones cerebrovasculares y la enfermedad de Alzheimer (EA). De hecho, los procesos inflamatorios se ...
Transcriptional and epigenetic re-programming of autoantigen-specific CD4+ T-cells by pMHC class II-based nanomedicines
[eng] Regulatory cells are essential to immune homeostasis. Both autoimmune diseases and the progression of cancer are related to alterations in the development and/or function of the regulatory compartment. In addition ...
Understanding PI3K signalling in vessel growth and pathophysiology
[eng] Our knowledge on the molecular basis behind physiological angiogenesis has significantly expanded in the last two decades. This progress also led to improvement in understanding of many vascular-related diseases in ...
Synaptic and circuit mechanisms of working memory and their dysfunction in anti-NMDA receptor encephalitis and schizophrenia
[eng] In this thesis, I investigate different synaptic and circuit mechanisms of working memory, how their interaction produces specific working memory biases, and how their disruption in psychiatric or neurological disease ...
Exploiting circulating lymphocytes and cell-free DNA as a source to develop minimally-invasive personalized T-cell therapies
[eng] Adoptive cell transfer (ACT) of tumor-infiltrating lymphocytes (TILs) can medi- ate tumor regression in patients with metastatic melanoma. Retrospective studies of TIL products from responders and non-responders have ...
Rol de las proteínas α- y γ-sinucleína en la neurotransmisión dopaminérgica nigroestriatal y mesocortical: Implicación en enfermedades neurodegenerativas y trastornos neuropsiquiátricos
[spa] Las sinucleínas son una familia de proteínas pequeñas y altamente conservadas en vertebrados, especialmente abundantes en las neuronas y típicamente enriquecidas en los terminales presinápticos, donde participan en ...
Neuromodulation interventions and EEG biomarkers for executive function in healthy and clinical populations
[eng] Executive function is defined as a subset of high-order cognitive functions (including working memory, inhibition, initiation and monitoring) that sustain adaptive goal-directed behavior and thought, and that are ...
