Universitat Pompeu Fabra
La UPF és una universitat pública, internacional i intensiva en recerca que està al nivell de les millors universitats europees. Amb excel·lents indicadors de producció científica com és el cas de les tesis doctorals en accés obert.
Si sou doctor o doctora de la Universitat Pompeu Fabra i voleu publicar la vostra tesi a TDX, contacteu amb CAU . Per a més informació consulteu Publicació de tesis a TDX. i les preguntes més freqüents
Human Immunodeficiency Virus Type 1 (HIV-1) remains a global pandemic requiring the development of curative strategies due to the limitations of current antiretroviral treatments (ART). This thesis focuses on the need for ...
This thesis aims to fill gaps in the research on breast microvasculature by creating a perfusable microvasculature system within a microfluidic platform. For the first time, we co-cultured primary breast endothelial cells ...
Pancreatic ductal adenocarcinoma (PDAC) is an unmet medical need characterized by a poor prognosis and high mortality. Until now, no effective therapies have been discovered to achieve disease control. Thus, there is an ...
Natural killer (NK) cells are cytotoxic innate lymphocytes which can recognize tumor targets or virus-infected cells. Adoptive transfer of primary or genetically engineered NK cells for cancer immunotherapy is an attractive ...
This thesis delves into the indispensable role of bacteria across our planet and their profound impact on various industries, encompassing health, agriculture, cosmetics, and materials science. It sheds light on the inherent ...
Spontaneous cellular errors can lead to cell death already in early embryo development. Apoptotic cell clearance is thus essential for tissue homeostasis and embryo survival. The outer epithelial layer of the embryo ...
The developing nervous system requires a well-orchestrated and diverse set of proteins, setting the foundation of how an animal perceives the world. Disruptions may result in neurodevelopmental disorders, including autism ...
In the context of the ongoing climate change emergency, there is growing concern about the impacts of increasingly extreme temperatures on children’s health, but the effects of extreme temperatures on children's brain ...
This thesis focuses on developing surface-enhanced Raman spectroscopy (SERS)-based nanosensors for real-time quantification of labile zinc in cancer cells and investigating the relationship between zinc dyshomeostasis and ...
Outdoor air pollution is an established lung carcinogen. In this thesis, we examined associations of outdoor air pollution and incidence of cancers other than lung cancer, as well as the role of air pollution in lung cancer ...
El proyecto tiene como objetivo general descifrar el mecanismo de la exocitosis utilizando biología estructural integrativa, lo cual ayudará a entender cómo las células controlan su crecimiento. Para ello, planteamos generar ...
This thesis is divided into three different sections. The first two sections involve the study of cell cycle and the third section is focused on meiosis. In the first chapter, we have developed a fluorescent-localized cell ...
La bronquiectasia es una enfermedad pulmonar compleja cuyas manifestaciones sistémicas han sido poco estudiadas. La presente tesis explora en profundidad la presencia y características de la sarcopenia en pacientes con ...
The thesis explores the potential of Glut1 ablation to enhance the antitumor activity of CD8+ T cells by inducing a metabolic shift from glycolysis to oxidative phosphorylation. Glut1-KO CD8+ T cells exhibited significantly ...
Durant el son, els estímuls sensorials externs es filtren mentre el cervell es prepara per consolidar nous records. Aquest equilibri sorgeix d’alternar recursos endògens entre la vigilància de l’entorn i la consolidació ...
Cancer co-opts alternative splicing to select isoforms that promote disease initiation, progression, and persistence. Drugs targeting either cancer driver splicing factors or specific splicing events can hamper the disease. ...
Climate change significantly exacerbates public health risks, particularly heat-related mortality. This PhD thesis examines the impact of human-induced climate change on heat-related deaths in Europe, focusing on regional ...
La insuficiencia cardíaca (IC) es un factor pronóstico crucial en pacientes con infarto agudo de miocardio con elevación del ST (IAMEST). La ecografía pulmonar es una técnica ampliamente estudiada en pacientes con insuficiencia ...
This thesis offers novel information on the clinical utility of LMO2, shown in three different studies. In the first one, we generated a round-robin testing validating the interobserver and interlaboratory reproducibility ...
Esta tesis se centra en mejorar la precisión de los objetivos quirúrgicos en pacientes con epilepsia resistente a los fármacos. Las redes cerebrales epileptogénicas exhiben cambios significativos en la conectividad durante ...
575 - General genetics. General cytogenetics. Immunogenetics. Evolution. Phylogeny (319)
576 - Cellular and subcellular biology. Cytology (205)
577 - Biochemistry. Molecular biology. Biophysics (166)
614 - Public health and hygiene. Pollution. Accident prevention (123)
