Universitat Pompeu Fabra
La UPF és una universitat pública, internacional i intensiva en recerca que està al nivell de les millors universitats europees. Amb excel·lents indicadors de producció científica com és el cas de les tesis doctorals en accés obert.
Si sou doctor o doctora de la Universitat Pompeu Fabra i voleu publicar la vostra tesi a TDX, contacteu amb CAU . Per a més informació consulteu Publicació de tesis a TDX. i les preguntes més freqüents
La bifurcación entre trofoectodermo y la masa celular interna es la decisión de desarrollo más temprana, pero cómo se inicia y en qué etapa embrionaria ocurre no se entiende completamente. Aquí describimos que el factor ...
Fragile X syndrome (FXS), the most common monogenic cause of intellectual disability and autism, is characterized by impairment in cognitive function and synaptic plasticity. Several preclinical studies in animal models ...
El linfoma folicular (LF) es el subtipo más frecuente de linfoma no-Hodgkin indolente, caracterizado por un buen pronóstico a pesar de considerarse incurable. Sin embargo, algunos pacientes presentan un curso clínico más ...
Myocardial infarction (MI) remains a leading cause of mortality, with currently available treatments addressing symptoms rather than promoting heart muscle regeneration. Cardiac regeneration strategies, inspired by ...
The expansion of the Roman Empire throughout the Mediterranean region and West Eurasia severely shaped the world culturally and politically. This period has been traditionally studied and researched by historians and ...
This PhD thesis investigates the relationship between temperature and mortality at different spatial and temporal scales, addressing a crucial issue in the context of rising temperatures due to anthropogenic climate change. ...
The resilience of proteins against degradation makes them the longest surviving resource for genomic information. Knowing how much information we can obtain from an ancient sample is crucial because most sampling strategies ...
In breast cancer, the tumor microenvironment includes adipocytes and fibroblasts. When in contact with breast tumor cells, adipocytes undergo lipolysis and dedifferentiation. This thesis demonstrates that cancer-associated ...
This thesis investigates the integration and analysis of OMICs data to enhance in silico modelling of real-world patients, with a special focus on prostate cancer. By leveraging publicly available transcriptomics data, ...
The current and projected rapid urbanization rates underscore the critical role of cities and the urgent need to prioritize the development of healthy and sustainable urban environments. Rising temperatures, intensified ...
RNA metabolism is dynamically orchestrated by RNA-binding proteins (RBPs) in different subcellular spaces. Aberrant regulation of the subcellular RNA-protein interactions leads to severe diseases, such as neural degenerations ...
Cancer develops from healthy cells due to mutations in around 600 cancer driver genes. These mutations, along with neutral ones, are generated from DNA mutational processes, creating distinct patterns known as mutational ...
Microorganisms exhibit remarkable adaptability and represent a vast genetic resource. Synthetic biology aims to leverage this diversity for sustainability and medicine. However, many microbes remain unexplored due to limited ...
This thesis explores the development of Environmental Risk Scores (ERSs) that go beyond traditional linear models to capture nonlinear relationships and interactions among a wide range of environmental exposures. Utilizing ...
Acute myeloid leukemia is an aggressive type of blood cancer with a poor survival rate. Leukemic stem cells (LSCs) govern the disease by producing rapidly dividing progenitor cells and driving relapse. Molecular characterization ...
Los productos químicos como los subproductos de desinfección (DBP) y las sustancias per- y polifluoroalquiladas (PFAS) se encuentran en el agua potable debido a su formación en los sistemas de distribución o su eliminación ...
The human histone H1 family comprises up to seven somatic subtypes. Using an integrative multi-omics approach that incorporates ChIP-Seq, Hi-C, RNA-Seq, and ATAC-Seq data, this thesis explores the genome-wide distribution ...
La present tesi descriu i analitza les desigualtats socials i econòmiques en la salut de la població infantil. Posa especial èmfasi en aquelles patologies més rellevants i en grups de població amb alt risc clínic. Altrament, ...
El objetivo de esta tesis es ampliar la comprensión de la relación entre vivienda y salud desde una perspectiva interseccional, y analizar los mecanismos que operan en esta relación. Realizamos tres estudios: 1) una revisión ...
Population genetics addresses evolutionary change in populations through time. Here we take a multifaceted approach to uncover the evolutionary history of gorillas. Firstly, we modelled the demographic history of gorillas ...
575 - General genetics. General cytogenetics. Immunogenetics. Evolution. Phylogeny (305)
576 - Cellular and subcellular biology. Cytology (192)
577 - Biochemistry. Molecular biology. Biophysics (160)
614 - Public health and hygiene. Pollution. Accident prevention (117)
