Programa de Doctorat en Biomedicina: Recent submissions
Now showing items 1-20 of 1373
El impacto de la vivienda cooperativa en la salud de las personas: compartir para vivir
El objetivo principal de esta tesis ha sido profundizar y ampliar en el conocimiento sobre la vivienda cooperativa y su impacto en la salud de las personas. Para alcanzar este objetivo, se han diseñado y llevado a cabo ...
Evaluation of topoisomers of snake venom-derived peptides as potential antimicrobial and antitumor agents
This thesis reports an investigation of the effect of topoisomeric modification on the activity of two peptides: crotalicidin (Ctn), a cathelicidin from the venom of a South American rattlesnake, and Ctn[15-34], a Ctn ...
Evolutionary dynamics of cancer drug resistance and prediction of tumor modes of growth
Cancer remains a significant challenge in healthcare and is a leading concern worldwide. Despite advances in cancer therapy and the identification of numerous actionable events, relapse and drug resistance continue to ...
Novel experimental strategies to characterize the genomic architecture of monogenic autoinflammatory diseases: from characterization of aberrant mRNA transcripts to elucidation of the role of post-zygotic variants in desease pathogenesis
Developments in sequencing technologies over the last decade have revolutionized the ability to identify the genetic mechanisms underlying rare autoinflammatory diseases (AIDs), enabling improved characterization and ...
The molecular mechanism of spindle pole focusing: NuMA as a dynein adaptor and microtubule minus end regulator
This project investigates the molecular mechanisms underlying chromosome segregation during eukaryotic cell division. Specifically, it explores the role of the motor protein cytoplasmic dynein 1 in maintaining metaphase ...
Unravelling the molecular pathways of auditory and vestibular function: the roles of sall1a and the fgf13 genes in the zebrafish inner ear development
L’oïda interna és un òrgan sensorial complex essencial per a les funcions auditiva i vestibular, que depèn de les cèl·lules ciliades per a la mecanotransducció i de les neurones sensorials per a transmetre senyals al sistema ...
New strategies for targeting transactivation domains: insights from the androgen receptor
Transcription factors are, in theory, ideal targets for developing new therapies, as they drive the expression of genes, oftentimes those that lead to pathologies. However, these proteins typically contain large intrinsically ...
Skin microbiome engineering: new generation of therapeutics: engineering Cutibacterium acnes to treat skin conditions
We are living in a symbiotic relationship with our Microbiome. This relationship with our microbes can become opportunistic and lead to dysbiosis. While we were previously treating dysbiosis with antimicrobial drugs, we ...
Elucidating the dynamics of the 3D GPCRome
G Protein-Coupled Receptors (GPCRs) are a diverse protein family integral to a wide range of physiological processes. Although their three-dimensional structures have been extensively characterised through experimental ...
The KANSL complex, an epigenetic regulator with microtubule binding properties in mitosis
La segregació dels cromosomes durant la divisió cel·lular està mitjançada per una estructura feta de microtúbuls anomenada el fus mitòtic. L’estructura i la funció del fus mitòtic depenen d’un control precís de les dinàmiques ...
Immune evasive mechanisms in breast cancer micrometastasis
In metastasis, the existence of tumor cells overcoming the immune system during early organ seeding is crucial, yet the dynamics of tumor-immune interactions during micrometastasis remain unclear. Identifying the vulnerabilities ...
Unraveling the effects of lymphoma-associated translocations on genome organization and gene regulation
Translocations have largely been associated with tumor development due to oncogene overexpression upon rearrangement. Yet, their precise effects on nuclear architecture and long- range gene regulation remain understudied. ...
Genetic determinants orchestrating transcriptome regulation: nonsense-mediated mRNA decay and allele-specific expression variability in phenotypic diversity
Esta tesis explora la variabilidad de la eficiencia de la degradación del ARN mensajero mediada por mutación terminadora (NMD) y el papel de la expresión específica de alelos (ASE) en la influencia de la variación fenotípica ...
Prediction and characterizacion of enhancer clusters in an induced cell-fate transition model
Large clusters of enhancers often regulate lineage instructive genes. Whether individual enhancers of a cluster cooperate or act independently in regulating gene expression is unknown. Current algorithms that identify such ...
Exploring the role of DYRK1 kinases in cell-autonomous and paracrine activities in pancreatic cancer
Dual-specificity tyrosine-regulated kinases (DYRKs) are a conserved family of protein kinases regulating critical cellular processes. This study investigates the roles of the paralogues DYRK1A and DYRK1B in pancreatic ...
From mitochondrial markers to whole genomes: evolutionary history of African and Arabian horned and sand vipers
This thesis adds new knowledge to the evolutionary history of the genus Cerastes, a group of understudied venomous snakes highly adapted to the arid conditions of North Africa and Arabia. Using several genomic approaches, ...
Development of new insecticide technologies against urban pests based on biomolecules
This industrial thesis provides insights into the development of new insecticide technologies against the cockroach Blattella germanica. We have focused this work on the design of an oral insecticide using RNA interference ...
The impact of amino acid insertions and deletions on protein stability and function
Amino acid insertions and deletions (indels) are common mutational events but there is limited information about their effects on protein stability and function. Whereas substitutions alter amino acid side chains, indels ...
Transport-mediated antimicrobial interactions and resistance mechanism in Escherichia coli
Esta tesis investiga los mecanismos de resistencia a antibióticos y la interacción entre antibióticos y toxinas en Escherichia coli, enfocándose en el paper del canal de membrana TolC en la expulsión de antibióticos e ...
Integrative methods for linking genotype to phenotype: an application to intervertebral disc degeneration
Intervertebral disc degeneration (IDD) is a complex condition influenced by genetics, environment, and lifestyle. Despite advancements in sequencing technologies, challenges remain in understanding the biology of complex ...
