Synthesis of compounds with potential biomedical activity: SARS-CoV-2 main protease inhibitors and ABA analogs

Autor/a

De la Hoz Rodríguez, Sergio

Director/a

González, Florenci ORCID

Tutor/a

González, Florenci ORCID

Fecha de defensa

2024-04-17

Páginas

313 p.



Departamento/Instituto

Universitat Jaume I. Escola de Doctorat

Programa de doctorado

Programa de Doctorat en Ciències

Resumen

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has increased the development of new antiviral drugs to stop its spread. This work focused on synthesizing specific inhibitors of the Mpro protease, crucial for the virus replication. Compounds with a nitroalkene-type "warhead" were synthesized, showing promising inhibitory activity against this enzyme. Additionally, inhibitors with a keto vinyl sulfone-type "warhead" were synthesized, showing variable inhibition trends against Mpro, CatL, and rhodesain. Furthermore, an ABA antagonist was synthesized, delaying shoot development and fruit generation, offering potential improvements in crop yield. Lastly, fluorescent derivatives of ABA were synthesized, shedding light on its cellular mechanisms. These findings contribute to the development of antiviral drugs and highlight the diverse roles of ABA beyond plants, potentially benefiting human health.

Palabras clave

SARS-CoV-2; Main protease; Warhead; Inhibitor; Abscisic acid

Materias

54 - Química; 615 - Farmacología. Terapéutica. Toxicología. Radiología

Área de conocimiento

Ciències

Documentos

Este documento contiene ficheros embargados hasta el dia 17-04-2025

Derechos

L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-sa/4.0/
L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-sa/4.0/

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