TDX (Tesis Doctorals en Xarxa): Recent submissions
Now showing items 1-20 of 44855
Factores Psicológicos Asociados al Desarrollo y Curso de las Adicciones Comportamentales o Adicciones sin Sustancia
[spa] INTRODUCCIÓN: Existe un debate epistemológico centrado en determinar cuál es el enfoque diagnóstico más adecuado en el campo de la salud mental, enfrentando modelo categorial frente al dimensional. El categorial ...
Targeting TREX2: an innovative keratinocyte-based therapy for psoriasis and atopic dermatitis
[eng] The fact that TREX2 is specifically expressed on KCs, upregulated in psoriatic skin and its loss leads to a decreased inflammation in mice models of the disease, points TREX2 as a candidate target for new KC-based ...
Uncovering TET2 chromatin targets at the leukemic onset
[eng] Epigenetic modifications, including DNA methylation, have been shown to play a prominent role in influencing cell identity in hematopoiesis. However, its role in gene regulation during differentiation remains poorly ...
Towards shock absorbing hyperelastic metamaterial design
(English) This thesis explores the possibilities and benefits of computational tools to be used in the analysis and design of shock absorbing metamaterials for industrial applications. The research is organized into two ...
Integración de la relación salud humana y cambio climático en el marco de la resiliencia urbana: propuesta metodológica de evaluación y operacionalización en un contexto latinoamericano
(English) This study addresses the relationship between climate change and human health in the framework of urban resilience in a Latin American context. It sought to strengthen the climate and health components through ...
Charting the alternative splicing vulnerabilities of cancer
Cancer co-opts alternative splicing to select isoforms that promote disease initiation, progression, and persistence. Drugs targeting either cancer driver splicing factors or specific splicing events can hamper the disease. ...
Attributing heat-related mortality to climate change
Climate change significantly exacerbates public health risks, particularly heat-related mortality. This PhD thesis examines the impact of human-induced climate change on heat-related deaths in Europe, focusing on regional ...
Evaluación del valor pronóstico de la ecografía pulmonar en el infarto agudo de miocardio con elevación del ST (LUS-AMI)
La insuficiencia cardíaca (IC) es un factor pronóstico crucial en pacientes con infarto agudo de miocardio con elevación del ST (IAMEST). La ecografía pulmonar es una técnica ampliamente estudiada en pacientes con insuficiencia ...
New insights into the clinical utility of LMO2
This thesis offers novel information on the clinical utility of LMO2, shown in three different studies. In the first one, we generated a round-robin testing validating the interobserver and interlaboratory reproducibility ...
A novel computational framework for identifying epileptogenic networks based on functional connectivity changes
Esta tesis se centra en mejorar la precisión de los objetivos quirúrgicos en pacientes con epilepsia resistente a los fármacos. Las redes cerebrales epileptogénicas exhiben cambios significativos en la conectividad durante ...
Psiquiatría nutricional aplicada al trastorno bipolar
[spa] INTRODUCCIÓN: El trastorno bipolar (TB) es un trastorno crónico del estado de ánimo caracterizado por fluctuaciones del estado de ánimo, que afecta a un amplio rango de población y se relaciona con un importante ...
Valoración de la reserva ovárica. Estudio de parámetros hormonales y ecográficos
[spa] INTRODUCCIÓN: Los marcadores de reserva ovárica son excelentes predictores de respuesta ovárica, pronóstico y riesgo de complicaciones en FIV/ICSI, aunque no son predictores de fertilidad natural. La determinación ...
Actívate con la APP O10K: una estrategia gamificada para fomentar la actividad física entre los estudiantes de la Universidad de Tarapacá, Arica
La inactivitat física entre els estudiants universitaris representa un problema significatiu amb implicacions negatives per a la seva salut a llarg termini. Aquest estudi va tenir com a objectiu avaluar l'efectivitat d'una ...
Earth abundant based nanostructured catalysts for CO2 reduction
La reducció electro-, foto- i fotoelectroquímica del CO2 impulsada per energies renovables està sorgint com a alternativa a tecnologies convencionals de transformació del CO2. No obstant, encara es requereixen catalitzadors ...
Development of advanced techniques to elucidate the intracellular trafficking of pßAE nanoparticles
Comprendre el comportament complex de les nanopartícules (NPs) dins dels sistemes biològics és essencial per avançar en el camp de la nanomedicina. Tanmateix, la visualització de la dinàmica de les NPs continua sent un ...
Multiband reconfigurable architectures with antenna boosters for wireless devices
L'augment de dispositius sense fils, incloent-hi, per exemple, els dispositius portàtils, sensors, comptadors i rastrejadors, ha generat una demanda de millor rendiment dins de dimensions limitades. Aquesta demanda s'estén ...
Advancing precision medicine in cancer and COVID-19 with bioinformatics: a multifaceted affair
[eng] Advancing precision medicine requires integrating bioinformatics to unravel complex biological data and translate these insights into clinical applications. This thesis explores the role of bioinformatics in enhancing ...
Sleep disorders in immune-mediated synaptic encephalopathies
[eng] INTRODUCTION: Autoimmune encephalitis (AEI) is an inflammatory disease of the central nervous system, caused by specific antibodies against synaptic or neural surface proteins. More than twenty have been described ...
Unveiling the role of the Mediator complex in Ewing sarcoma tumorigenesis
[eng] Ewing sarcoma is an aggressive tumor arising in bones and soft tissues that affects children and young adults. This disease is determined by an aberrant chromosomal translocation that forms an oncogenic fusion protein, ...
Access mechanisms for massive Internet of Things in 5G and beyond networks
(English) The Massive Internet of Things (MIoT) characterizes a communication scenario where a massive number of battery-operated devices perform infrequent, primarily uplink-oriented small data transmissions to a network. ...
