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Deciphering the functional organization of molecular networks via graphlets-based methods and network embedding techniques
[eng] Advances in capturing technologies have yielded a massive production of large-scale molecular data that describe different aspects of cellular functioning. These data are often modeled as networks, in which nodes are ...
Deciphering the genetic architecture of prolificacy related traits in an experimental Iberian x Meishan F2 intercross
Els caràcters reproductius són de gran interès en la indústria porcina per tal de millorar l’eficiència productiva. En estudis previs, utilitzant un creuament experimental F2 entre les races Ibèric (Ib) i Meishan (Me) es ...
Deciphering the interaction between Kvl.3 and Caveolin
The voltage-dependent K+ channel Kv1.3 participates in many physiological events like proliferation and activation of immunitary cells, membrane repolarization in sensory neurons, vascular smooth muscle tone, insulin ...
Deciphering the molecular and phenotypic effects of a Drosophila melanogaster transposable element located in a unique insertional cluster
Understanding how organisms adapt to their environment remains an open question in Biology. So far, most projects focus on the study of single nucleotide polymorphism variants, while other types of mutations, likely to ...
Deciphering the nuclear function of folate enzyme MTHFD2 in cancer: a novel role for nuclear MTHFD2 in mitosis
Subcellular compartmentalisation of metabolic enzymes may elicit specific cellular functions by establishing a unique metabolic environment. Indeed, the nuclear translocation of certain metabolic enzymes impacts epigenetics ...
Deciphering the regenerative response of peripheral neuron subtypes after nerve injury
Les neurones perifèriques poden regenerar després d’una lesió nerviosa, però la recuperació funcional sol ser limitada. Després d’una axotomia, les neurones experimenten canvis en l’expressió gènica, passant a un estat ...
Deciphering the role of alternatively spliced microexons during vertebrate nervous system development and function
Neural microexons are the most conserved type of alternative splicing, suggesting a strong functional relevance. Consistently, mutation of their master regulators leads to dramatic neurodevelopmental alterations and ...
Deciphering the role of endothelial cells in the regulation of physiological and pathological white adipose tissue remodelling
In response to nutritional variation, white adipose tissue (WAT) undergoes a physiological remodelling that involves qualitative and quantitative changes in resident cells and is coordinated with angiogenesis. In a condition ...
Deciphering the role of innate immune response in the model of tuberculosis in Drosophila melanogaster
Actualment, s’estima que una tercera part de la població mundial està infectada per Mycobacterium tuberculosis (Mtb). Tot i això, només un petit percentatge desenvoluparà la malaltia activa. S’ha demostrat que aquesta ...
Deciphering the role of peripheral and central nervous system metabotropic glutamate receptors in neuropathic pain with photoactivable ligands
Pain is one of the main medical problems that in several cases results into a chronic disease with limited effective treatment, thus the discovery of new drugs to fight against constitutes a big challenge nowadays. Metabotropic ...
Deciphering the role of RBM10 in development and cancer using a genetic mouse model
Short explanation English To reveal how RBM10 loss contributes to development and cancer we have established Rbm10 constitutive and conditional knockout mouse models and have analyzed phenotypes at the organismal and ...
Deciphering the structure and dynamics of the vault particles
[eng] The vault particle, with a mass of 10 MDa and dimensions of 70 nm x 40 nm x 40 nm, is the largest ribonucleoprotein described in the eukaryotic kingdom. The vault shell is organized in two identical moieties, each ...
Deciphering the utility of Galleria mellonella as an infection and toxicity in vivo model
Galleria mellonella (greater wax moth) is a popular animal model that has been extensively used as an alternative in vivo model for investigating the virulence and pathogenicity of different bacteria. G. mellonella has ...
“Decir” de Jomí García Ascot
Paulatinament, estan proliferant els estudis d'alguns dels escriptors en llengua hispana que van condensar la seva creació literària a païssos estrangers donada la seva condició d'exili. Els anomenats "nens de la guerra" ...
Decision analysis under uncertainity for sustainable development
Policy-making for sustainable development becomes more efficient when it is reliably backed by evidence-based decision analysis. Concretely, this is crucial in the planning of public services delivery. By translating "raw" ...
Decision Analysis, Uncertainty Theories and Aggregation Operators in Financial Selection Problems
The complexity of financial analysis, particularly on selection process or decision making problems, has increased rapidly over several decades. As a result, much attention has been focused on developing and implementing ...
Decision Building Information Modeling (BIM)-Supported Tools for a Fair Transition Towards More Environmentally Sustainable Buildings
El sector de la construcció és un contribuent significatiu als reptes ambientals com el consum d'energia, el canvi climàtic i l'esgotament de recursos. Eines de suport a la presa de decisions (DST), com l'Avaluació del ...
Decision Making in complex scenarios: a Reinforcement Learning Approach
[eng] Our everyday actions are sequential and chained towards accomplishing goals. As an adaptive strategy, our tasks are divided and organised in stages leading up to an ultimate objective, which is specified by reaching ...
Decision making in digital health: usage of the cost-effectiveness analysis to improve the sustainability of the healthcare system
Healthcare systems worldwide are facing a number of challenges that are conjunctural to the historical moment and are somehow reshaping a discipline as traditional as medicine. The five major challenges that are defining ...
Decision Making Tools for Sustainable Transition Toward Low Carbon Energy Technologies in the Residential Sector
Aliniant-se amb l’ambiciós paquet energètic i climàtic de la UE 2030 per reduir les emissions d’efecte hivernacle i substituir les fonts de calor convencionals mitjançant la presència de participacions d’energia renovable ...
