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Mostrando ítems 40566-40585 de 41845
Unmasking African swine fever virus antigens inducing CD8+ T-cell responses with protective potential
La contínua propagació de la pesta porcina africana (PPA) a l’Europa continental després de la seva introducció a Georgia l’any 2007, així com l’expansió a Àsia a partir del 2018, posa en evidència la gran amenaça que ...
Unmasking the microbicidal and immunostimulatory properties of warthog fecal microbiota in vitro and in vivo
El virus de la Pesta Porcina Africana (VPPA) és l’amenaça principal per a la indústria porcina. L’absència de vacunes enfront del virus complica el control i erradicació de la malaltia que provoca: la Pesta Porcina Africana ...
Unnamed Woman. Uncovering links between gendered violence, murder, and environmental conflicts
Els conflictes ambientals sorgeixen a mesura que les indústries extractives s’apoderen de la força de les terres i els recursos de les comunitats marginades per a projectes ecològics i socials perjudicials com ara la ...
Unpacking the Many Natures of Organizational Paradox: From Transformative Dynamics to Bundles of Paradoxes in Grand Challenges
Els grans desafiaments a què ens enfrontem estan plens de paradoxes organitzatives. Els problemes socials complexos estan plens de moltes contradiccions persistents i interdependents que s'entrellacen de diferents formes. ...
Unraveling biotic and environmental factors driving fungal dynamics
Els fongs són microorganismes que juguen un paper crucial en els processos ecosistèmics. D'entre tots els grups funcionals de fongs (sapròfits, floridures, paràsits, etc.), els fongs micorízics són especialment importants ...
Unraveling CK2 inhibition and temozolomide contribution to therapy response in preclinical GL261 glioblastoma: immune system implications and magnetic resonance based nosological imaging
El glioblastoma (GB) es el tumor primario más común en adultos. Debido a su mal prognóstico, es urgente encontrar mejoras en su tratamiento. El objetivo de esta tesis es estudiar el efecto de inhibidores de CK2 y del agente ...
Unraveling luminal breast cancer heterogeneity
Metastasis is the major cause of death from Breast Cancer (BCa). During its progression, divergent opinions have arisen regarding the hormonal status of the BCa subtypes. The mammary gland is composed of different cell ...
Unraveling new roles and substrates for protein kinase CK2 in arabidopsis thaliana
Aquesta tesi és part d’un projecte d’investigació més general que té com a objectiu estudiar el paper de la serina/treonina quinasa CK2 en el desenvolupament de les plantes, utilitzant Arabidopsis thaliana com a model. ...
Unraveling new roles of geranylgeranyl diphosphate synthases and phytoene synthases in tomato
Els carotenoides són compostos isoprenoides essencials per a la fotosíntesi, la fotoprotecció, i com a precursors de reguladors del creixement com l’àcid abscísic (ABA) i les estrigolactones (SL). En algunes plantes, com ...
Unraveling novel roles of the cellular decapping activators Lsm1-7 and Dhh1 in translation control through viral studies
Translation control is a vital aspect of gene expression for both viruses and their cellular hosts. We have previously shown that the cellular mRNA decay activators Dhh1 and Lsm1-7 promote translation of positive-strand ...
Unraveling potential disease modifiers of myotonic dystrophy type 1
[spa] La distrofia miotónica tipo 1 (DM1) es un trastorno multisistémico, progresivo y no tratable con una expansión CTG en el gen DMPK que es la base de la patología. La compleja naturaleza multisistémica de la DM1 ...
Unraveling the biological role of latexin in cell fate specification
Latexin es un gen de respuesta a ácido retinoico (RA) cuya función celular se conoce escasamente. Latexin se encuentra silenciada por un mecanismo de hipermetilación en numerosas líneas tumorales, sugiriendo que ésta podría ...
Unraveling the complex signaling behavior of neurotransmitters and their receptors in the brain
G protein-coupled receptors (GPCRs) are the main acceptors of neurotransmitters, and thus play an important role in communication between neurons. Because of this they are an attractive drug target for multiple neurodegenerative ...
Unraveling the Dynamics and Equilibrium Behavior of Pure and Mixed Micelles: Insights from Microscopic coarse-grain modeling
Aquesta tesi es centra en explorar i controlar els mecanismes darrere de la formació i el comportament dinàmic de micel?les pures i mixtes, les quals són àmpliament utilitzades en moltes indústries. Es proposen simulacions ...
Unraveling the functional roles of sftb-1/SF3B1 and prpf-4/PRPF4B in Caenorhabditis elegans splicing and human disease
Caenorhabditis elegans provides a powerful experimental system for understanding fundamental questions in biomedical research, including the consequences of pre-mRNA splicing alterations. Here, we have applied CRISPR and ...
Unraveling the Fundamental Aspects of Enzyme-powered Micromotors
[eng] Enzyme-powered motors are based on the micro- and nanosized particles that propel thanks to the chemical conversion of enzymes attached on their surface. Recently, these tiny devices have been applied for a plethora ...
Unraveling the molecular mechanisms involved in RCAN-peptide mediated inhibition of calcineurin-NFAT signaling and its potential as an inhibitor of tumor progressions
The calcineurin-NFATc signaling pathway is involved in many aspects of the development and function of the immune, neural, skeletal, cardiovascular and muscular system of vertebrates. Regulators of Calcineurin (RCAN) ...
Unraveling the success of invaders: biotic and abiotic factors determining the invasibility of Mediterranean benthic assemblages by Caulerpa cylindracea
Biological invasions have become one of the most pervasive threats to native ecosystems worldwide, causing species extinctions, disrupting the functioning of ecosystems, altering the provision of critical ecosystem services ...
Unravelling 3D cargo transport dynamics at the microtubule network with super-resolution microscopy
Intracellular transport plays an essential role in a wide variety of fundamental cellular processes required to maintain the internal regulation and organization of cells. Different types of cargos such as organelles, ...
Unravelling cell-particle interactions for the design of new micro- and nanoengineered systems
Els micromaterials i nanomaterials presenten unes propietats fisicoquímiques úniques i controlables, les quals han permès la creació d’eines innovadores per tal d’afrontar alguns dels reptes que presenten diferents branques ...
