Browsing Universitat de Barcelona by Title

Novel Disulfide Formation Strategies in Peptide Synthesis

Postma, Tobias Maria (Date of defense: 2014-03-21)

Cysteine (Cys) is a unique amino acid due to its ability to form reversible covalent disulfide bonds. These bonds cause conformational constraints which make peptides or proteins more rigid and stable. In addition, the ...

Novel functions and interactors for Brassinosteroid receptors In Arabidopsis thaliana = Noves funcions i interactors pels receptors de Brassinosteroids d’Arabidopsis thaliana

Fabregas Vallvé, Norma (Date of defense: 2013-09-20)

The general objective of this PhD thesis is to investigate the mechanistic bases for plant hormones Brassinosteroids (BRs) action in plant vascular development. To this end, we have used a multidisciplinary approach by ...

Novel light management techniques for thin film solar cells: Nanotextured substrates and transparent conducting upconverters

Lluscà Jané, Marta (Date of defense: 2015-07-10)

The objective of this work was to study two different light management approaches to enhance the efficiency of thin film Si solar cells and these were the manipulation of the light path (light trapping) and changing the ...

Novel Lipases: Expression and Improvement for Applied Biocatalysis = Nuevas lipasas: expresión y mejoras para biocatálisis aplicada

Infanzón Ramos, Belén (Date of defense: 2017-09-15)

This thesis is focused in the identification and improvement of lipases for biotechnological application. The importance of lipases is increasing in several industries. However, the commercial use of lipases is still a ...

Novel markers and targets of collective tumor cell invasion before and after anti-angiogenic therapies

Sallaberry Pinto, Júlia (Date of defense: 2019-03-22)

Local invasion is a key cell-biological event in the metastatic cascade. In response to a changing microenvironment, cancer cells may act using two main strategies of invasion: single cell invasion and collective invasion. ...

Novel mechanisms and transcription factors involved in the control of stomatal behaviour in Arabidopsis thaliana / Nuevos mecanismos y factores de transcripción involucrados en el control del comportamiento estomático en Arabidopsis thaliana

Legnaioli, Tommaso (Date of defense: 2013-02-26)

The increase in water use efficiency in order to maintain or improve crop yields in times of global warming and progressive reduction of water resources is one of the major challenges faced by agricultural sciences in the ...

Novel methodologies for the conjugation and cyclisation of polyamides

Brun Cubero, Omar (Date of defense: 2016-07-27)

An alternative allowing diene-derivatised polyamides to be used in Diels-Alder conjugation reactions has been explored and developed. In this methodology, conjugation takes place between a fully protected, resin-linked ...

Novel molecular alterations in amyotrophic lateral sclerosis and frontotemporal lobar degeneration spectrum

Andrés Benito, Pol (Date of defense: 2019-12-17)

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are clinically distinct neurodegenerative diseases that are connected by genetic and pathological overlap. ALS patients present with muscle ...

Novel multi-target directed ligands as drug candidates against Alzheimer’s disease

Pérez Areales, Francisco Javier (Date of defense: 2017-07-14)

Alzheimer’s disease (AD) is the main neurodegenerative disorder and one of the most important health-care problems worldwide, because of its high prevalence and personal and economic impact. To aggravate this situation, ...

Novel nanoscale therapeutic approaches to treat liver diseases

Perramón Corominas, Meritxell (Date of defense: 2022-10-17)

[eng] Chronic liver diseases are one of the most prevalent diseases worldwide. The study of the signaling pathways involved in the fibrogenic process as well as the evaluation of novel therapies such as nanoparticles (NPs) ...

Novel phenotyping and monitoring approaches to assess cereal performance under abiotic stress conditions = Nuevos enfoques de fenotipeado y monitoreo de cultivos para evaluar el rendimiento de cereales cultivados en diferentes condiciones de estrés abiótico

Khaled Elazab, Abdelhalim (Date of defense: 2015-07-13)

Cereals are the basis of the normal diet in most Mediterranean countries and it is estimated that they account for 35-50% of the regional populations’ dietary energy consumption. Water deficit is the main constraint limiting ...

Novel potential determinants in endoplasmic reticulum stress, inflammation and insulin resistance: Apo CIII and sAPPβ

Botteri, Gaia (Date of defense: 2018-03-14)

Diabetes represents one of the biggest health challenges of the 21st century. Insulin resistance is the primary defect in the most common form of diabetes, type 2 diabetes mellitus (T2D), and is defined as a failure in the ...

Novel quantum phenomena and excitation modes in type-I superconductors and magnetic vortices

Zarzuela Fernández, Ricardo (Date of defense: 2014-11-27)

The aim of this thesis was to study quantum phenomena and excitation modes in type-I superconductors and magnetic vortices. The intermediate state in type-I superconductors is characterized by the gradual penetration ...

Novel Quatsome nanovesicles, prepared using CO2, for the development of advanced nanomedicines

Vargas Nadal, Guillem (Date of defense: 2020-10-23)

Quatsomes are lipid-based nanovesicles developed by Nanomol group, composed of ionic surfactants and sterol derivatives. Regarding their properties, Quatsomes have shown to be highly homogenous and stable for years, important ...

Novel regulation of AMPA receptor function by interacting protein CPT1C

Yefimenko Nosova, Natalia (Date of defense: 2016-06-17)

AMPA receptors (AMPARs) are responsible for the 90% of synaptic transmission and are involved in plasticity, developmental and neurological processes. Their function depends on the proteins interacting with the AMPAR ...

A novel regulatory unit in the N-terminal region of c-Src

Arbesú Andrés, Miguel (Date of defense: 2018-03-02)

c-Src is a central player in several cellular signaling pathways. It controls impor- tant cellular processes like cellular proliferation, survival or motility. Therefore, a number of tumoral diseases have been related to ...

A novel role of the c-Jun NH(2)-Terminal Kinase (JNK) in obesity-associated insulin resistance

Morcillo Sánchez, Melisa (Date of defense: 2021-03-24)

Obesity is the most common metabolic disorder that have alarmingly increased all over the world in the last few decades. The hormone insulin is one of the major endocrine axis deregulated in obesity and will be the focus ...

Novel roles for the mitotic kinase Nek7 in hippocampal neurons

Avó Freixo, Francisco Duque Projecto (Date of defense: 2016-10-20)

The microtubule cytoskeleton plays essential roles during cell division, migration, differentiation, defining cell morphology and organizing intracellular transport. The properties of microtubules, such as their stability, ...

Novel sensors technologies applied to force spectroscopy in molecular biology

Gonzalez Claramonte, Laura (Date of defense: 2014-12-09)

Force plays an essential role in all fields of biology. Measurement of these forces with high precision provides information about the structure, dynamics, intra and intermolecular interactions, and the mechanical properties ...

Novel Specific Receptor‐based Techniques for Antibiotic Residue Analysis

Adrián Izquierdo, Javier (Date of defense: 2012-09-28)

The indiscriminate and/or improper use of veterinary drugs is the cause of potential adverse health effects due to the risk of entering into the food chain and the appearance of residues in food products of animal origin. ...