Universitat Pompeu Fabra
Mostrando ítems 3187-3206 de 3499
This dissertation describes youth language as it is represented in contemporary novels published in English and its subsequent translation into Catalan. Youth language is especially appealing for the study of written fiction ...
It has been well-established that progressive accumulation of genetic mutations in proto-oncogenes and tumor suppressors induces cancer. However, the early molecular mechanisms leading to tumor initiation remain elusive. ...
Human epidermis relies on a population of adult stem cells to maintain its homeostasis. Stem cells transit from a dormant to an active state and undergo a tightly regulated process of differentiation that replenishes the ...
Gene expression, epigenetic states and topological conformation are three fundamental aspects of genome organization that are tightly regulated in space and time. Epigenetic states, protein occupancy and chromatin ...
The natural daily cycles of light and dark have played a fundamental role in shaping the development of an adaptive intrinsic clock mechanism which allows organisms to coordinate the function ...
This thesis is a collection of three principal chapters split into two parts. The first part presents chapter 1 on network design when effort decisions are global substitutes but communication through network links creates ...
Our everyday perception of the world is remarkably unambiguous, considering that it stems from a multitude of ambiguous sensory signals. This feat is believed to be achieved by a set of perceptual and cognitive mechanisms ...
When interacting with the world, agents take actions they consider optimal, that is, best. Typically, this optimality is evaluated over the entire space of possibilities. However, agents are inherently bounded -- for ...
We recently identified a novel cyclin called Cyclin O which is able to bind and activate Cdk1 and Cdk2 in response to intrinsic apoptotic stimuli like DNA damage or ER stress. Cyclin O has been shown to be involved in the ...
Mitochondrial dysfunction arising from aberrant mitochondrial nucleic acid homeostasis has been associated with various pathologies. In this thesis, we aim to characterize a putative mitochondrial exonuclease, EXD2, and ...
Newborns are able to perceive sound of many languages. However, throughout their first year of life, both biological maturation and language exposure attune infants’ perceptual systems to the characteristics of their ...
In response to fluctuations in the environment, all living organisms have the ability to sense, respond and adapt to the new conditions. In budding yeast (Saccharomyces cerevisiae) there is a massive and rapid reorganization ...
MacroH2A1.1 is one of the least understood histone variants and structural components of chromatin. Generated by alternative splicing, macroH2A1.1 differs from the other macroH2A1 isoform in its capacity to bind NAD+-derived ...
Both manual and automatic methods for Machine Translation (MT) evaluation heavily rely on professional human translation. In manual evaluation, human translation is often used instead of the source text in order to avoid ...
Brain circuits display modular architecture at different scales of organization. Such neural assemblies are typically associated to functional specialization that favours both the segregation and the integration of ...
This thesis investigates the role that different aspects of audiovisual prosody play in the production and perception of interrogativity. To this end, two types of statements and two types of questions are analyzed: ...
During cell division, a macromolecular machine is assembled to segregate the two sets of chromosomes carrying the genetic material into the two daughter cells. This machine, the mitotic spindle, is a bipolar array composed ...
The life-long production of blood cells is enabled by hematopoietic stem and progenitor cells (HSPC) residing in the bone marrow. An understanding of the genes that control how HSPCs work to sustain the continued production ...
Mitosis is the essential process during which a cell divides into two viable daughter cells. To allow a faithful segregation of the chromosomes into each daughter, the cell forms the bipolar spindle. The NIMA-like kinase ...
Introduction: Occupational exposures are considered to be one of the newer and important risk factors for Chronic Obstructive Pulmonary Disease (COPD) besides tobacco smoking. However, the evidence mostly comes from smaller ...
