Mostrando ítems 1-20 de 72
Mateo Ramos, Lídia (Fecha de defensa: 2019-12-18)
Durant la darrera dècada la seqüenciació massiva de pacients de cancer ha permés avançar de forma significativa el coneixement sobre les bases moleculars del càncer. Un cop assolit aquest primer pass, el repte que tenim ...
Gregori Puigjané, Elisabet (Fecha de defensa: 2008-07-08)
La representació de les molècules per mitjà de descriptors moleculars és la base de moltes de les eines computacionals pel disseny de fàrmacs. Aquests mètodes computacionals es basen en l'abstracció de l'estructura química ...
An, Weiteng (Fecha de defensa: 2021-04-14)
Peptide-based vaccines have raised as an attractive alternative strategy to overcome many of the limitations of conventional vaccines. Some drawbacks for an optimal immune response in vivo are, a poor immunogenicity, ...
Martínez Rosell, Gerard (Fecha de defensa: 2017-12-20)
In this thesis we apply molecular dynamics (MD) simulations and other in silico techniques in drug discovery. Specifically, (a) we developed an algorithm to detect cryptic pockets based on MD simulations of the protein ...
Olesti Muñoz, Eulàlia (Fecha de defensa: 2018-11-29)
In the last decade, the rapid emergence of a group of compounds known as novel psychoactive substances (NPS) has become a worrying problem due to their ambiguous legal status, their easy availability, their extensive ...
Such Sanmartin, Gerard (Fecha de defensa: 2010-01-28)
Human growth hormone (GH) participates in human longitudinal growth, lipid and carbohydrate metabolism, and comprises a remarkably number of proteins with similar sequences, generated either genetically or post-translationally, ...
Pinyot Comelles, Armand (Fecha de defensa: 2012-10-24)
La present tesis doctoral desenvolupa una nova metodologia analítica antidopatge. Degut a que actualment la detecció de l'abús d'hormona del creixement recombinant està relativament resolt, es tem que els secretagogs de ...
Duran-Frigola, Miquel (Fecha de defensa: 2016-01-28)
The avalanche of data that followed the sequencing of the human genome has revealed an overwhelming biological complexity. No simple molecular explanation exists for most of the diseases and, in consequence, simple therapies ...
Canet, Maëlle (Fecha de defensa: 2023-03-30)
Though Computed Tomography (CT) plays an essential role in healthcare, several large-scale cohort studies have reported an increased cancer risk following CT-radiation exposure in childhood. Results may be subject to ...
Luján Pérez, Miguel Ángel (Fecha de defensa: 2020-03-13)
Cocaine addiction is a chronic, relapsing disease characterized by the compulsive seeking and use of the drug despite its harmful consequences. Currently, there are no approved pharmacotherapies available for the treatment ...
Gallo, María (Fecha de defensa: 2021-07-22)
This thesis focuses on one of the biggest challenges facing drug discovery field: the efficient targeted delivery of therapeutic compounds, and how cell-penetrating peptides (CPPs) acting as drug delivery vectors can ...
Fernández-Velilla Cepria, Enric (Fecha de defensa: 2023-01-25)
Dual-Spiral Dual-Energy Computed Tomography is an emerging technology that is being introduced in Radiotherapy Departments of hospitals because of its cost and simplicity. There is still a lack of literature about its ...
Jalencas i Giménez, Xavier (Fecha de defensa: 2013-09-17)
In medicinal chemistry, two chemical fragments are considered bioisosteric if they bind to the same protein environment. Accordingly, looking at the same players from an opposite perspective, two protein environments can ...
Ripoll Pastor, Greta (Fecha de defensa: 2021-05-10)
Serologic tests detecting anti- T. gondii IgM are the gold standard for the diagnosis of acute toxoplasmosis. Nevertheless, most commercial kits are based on lysate antigens obtained from tachyzoites grown in mice or tissue ...
O'Mahony, Brian (Fecha de defensa: 2008-11-17)
La 3,4-metilenodioximetanfetamina (MDMA, éxtasis) es una anfetamina sustituida de consumo frecuente y abusivo. La enzima principal que participa en el metabolismo de fase I de la MDMA, la isoforma 2D6 (CYP2D6) del citocromo ...
Popota, Foteini D. (Fecha de defensa: 2014-11-27)
Positron emission tomography (PET) has been well established the last years as a powerfull tool in research and clinical applications. Advances in technology have enabled the use of small animal PET imaging in preclinical ...
Jiménez Otero, Cintia (Fecha de defensa: 2007-01-12)
L'anàlisi qualitatiu ha estat sempre molt important en el control antidopatge i constitueix cada cop més una part molt significativa de l'activitat diària d'altres tipus de laboratoris. Tanmateix, no existeixen guies o ...
Esquivel López, Argitxu (Fecha de defensa: 2018-12-14)
Anabolic androgenic steroids (AAS) are widely used by athletes to enhance sports performance. In this thesis, different studies were performed to evaluate the potential of the direct detection of phase II metabolites by ...
Bosch de Basea i Gómez, Magda (Fecha de defensa: 2016-11-28)
The present thesis introduces the EPI-CT cohort study; a European collaborative effort aimed at quantifying the health risks of computed tomography (CT scan) radiation exposure during childhood and assesses the main ...
Skalic, Miha (Fecha de defensa: 2019-07-30)
Designing novel drugs is a complex process which requires finding molecules in a vast chemical space that bind to a specific biomolecular target and have favorable physio-chemical properties. Machine learning methods can ...