Universitat Pompeu Fabra
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17β-nandrolone (17βN) is illegally used in sport and in livestock as a growth promoter.17βN and some of their metabolites have been described as endogenous compounds in some animals, such as adult boars and entire male ...
Los agentes anabolizantes prohibidos por la Comisión Médica del Comité Olímpico Internacional (COI) deben estar ausentes en las muestras de orina objeto de análisis. El límite de detección está condicionado por la ...
El di(2-etilhexil) ftalat (DEHP) és un plastificant que s’afegeix als productes de clorur de polivinil (PVC) per a dotar-los de més flexibilitat. El material mèdic fet de PVC, i en particular els dispositius i bosses que ...
Erythropoietin (EPO) is a glycoprotein hormone, the molecule comprises a single polypeptide chain of 165 aminoacids with two disulfide bonds, 1 O-linked (Ser-126), and 3 N-linked (Asn-24, 38, 83) glycans representing about ...
Despite the investment of vast amounts of money over the last decades, drug discovery and development remains an inefficient process, which can be stopped at different steps, leading to the loss of all resources invested. ...
Safety concerns are one of the main causes of drug attrition. In these events, the moment at which the drug toxic effects are discovered changes dramatically the importance of the finding; discarding a valuable candidate ...
Hem desenvolupat noves eines de software per tal d’obtenir informació de fonts publiques i privades per tal de desenvolupar models de toxicitat in silico. La primera eina es Collector, una aplicació de programari lliure ...
The explosion of reductionist approaches at the end of the XXth century allowed for fast and high-throughput data collection in pharmaceutical industry, but did not deliver the expected gain in drug discovery performance. ...
Positron emission tomography (PET) is a functional imaging method that allows studying physiological, biochemical or pharmacological processes in vivo. PET is being used in both research and clinical practice. In the brain, ...
Maternal alcohol binge drinking during pregnancy can be deleterious for the developing foetus, leading to a wide range of long-lasting morphological and neurobehavioural disabilities known as foetal alcohol spectrum ...
L'habilitat de petites molècules per interaccionar amb múltiples proteines no és exclusiva dels fàrmacs, sino de la majoria de compostos, incloent els metabòlits endogens dels organismes, desde les plants fins els humans. ...
Aquesta tesi presenta els estudis realitzat per avaluar el paper de diferents neurotransmisors i neuromoduladors en respostes de tipus emocional, en el control dels efectes reforçants i gratificants de diverses drogues ...
L'hexaclorobenzè (HCB) és un compost organoclorat àmpliament distribuït per tot el planeta, altament lipofílic que s'acumula als sistemes biològics. Els nounats s'exposen a aquests compostos organoclorats (OCs) a través ...
This project was set out to broaden our knowledge of the processes driving the emergence of antifungal drug resistance in an opportunistic yeast pathogen Candida glabrata. More precisely, we sought to find the mutational ...
The evaluation of olive oil antioxidants, hydroxytyrosol and tyrosol, in vivo biological activities is challenged due to scarce data on their metabolic disposition and activities of their glucuronides, main metabolites ...
This work describes the discovery and optimization of efficient, selective, cost-effective and proteolytic-resistant antimicrobial and antitumoral peptides. To this end, we first identified novel cathelicidin-related ...
Classically it was assumed that the compounds with therapeutic effect exert their action interacting with a single receptor. Nowadays it is widely recognized that the pharmacological effect of most drugs is more complex ...
Systems pharmacology is the discipline that studies the so-called ‘pharmacological space’ with a holistic and network-based perspective. Its challenge is to shed light on the astonishingly sophisticated biological processes ...
A great deal of efforts has been made to improve and expand pharmacological testing and optimisation of drug candidates during the discovery process. However, we are yet to understand fully why drugs require certain ...
Metabolic studies of doping agents have been traditionally performed by using gas chromatography coupled to mass spectrometry (GC-MS). In the last years, liquid chromatography coupled to mass spectrometry (LC-MS) has ...
