Now showing items 1667-1686 of 3289
Cohen Montoya, Alfredo E. (Date of defense: 2016-10-21)
Este trabajo es un compromiso para acercar la academia a las necesidades de la sociedad. Se trata de una investigación evaluativa, de corte cualitativo, realizada en el Instituto de Educación Superior Menéndez i Pelayo ...
Di Giacomo, Valeria (Date of defense: 2014-12-12)
P63 is a transcription factor of the p53 family with key roles in embryonic development, stem cells and cancer. P63-deficient mice fail to form stratified and glandular epithelia, including the prostate, demonstrating a ...
Jagiełło, Bogumiła (Date of defense: 2018-12-05)
La localització de molècules d'ARNm permet regular la síntesi de proteïnes localment i temporalment i això és vital per molts processos cel·lular fonamentals. A Oligodendròcits el transport de l'ARNm de la proteïna bàsica ...
Ritschka, Birgit (Date of defense: 2017-09-15)
Cellular senescence has mainly been associated with tumor suppression and aging, mediated through cell intrinsic cell-cycle inhibition and arrest. However, through secretion of specific proteins, termed the senescence-associated ...
Lucas, Morghan C. (Date of defense: 2023-04-24)
The aim of this thesis is to delve into sperm RNA dynamics during maturation and paternal inheritance. To obtain an integrative multi-omics view of sperm RNA during these processes, I turned to the new direct RNA sequencing ...
Rai, Madhulika (Date of defense: 2018-01-29)
Genetically tractable model organisms may help to identify new approaches to stop malignant growth. During the first part of my doctoral thesis, I have participated in a high content screen carried out to this end taking ...
Tu, Xiaochuan (Date of defense: 2023-07-27)
Embryonic stem cells (ESCs) are derived from the inner cell mass of the pre-implantation embryo and can recapitulate early developmental stages of the embryo. ESCs have the ability to continuously propagate while maintaining ...
Cortés Albarracín, Paola Andrea (Date of defense: 2019-12-02)
Mouse embryonic stem cells (ESCs) require extracellular signals to induce the expression of intrinsic core pluripotency factors: Oct4, Sox2 and Nanog, known as the OSN triad. Notably, the Wnt/β-catenin pathway has been ...
Aulicino, Francesco (Date of defense: 2016-12-15)
The adaptive response of cells to external stimuli is an intriguing mechanism at the basis of the existence of life itself. For this purpose, signalling pathways and gene regulatory networks elegantly evolved translating ...
Storer, Mekayla (Date of defense: 2014-12-18)
Cellular senescence is an irreversible form of proliferative arrest, historically linked to tumour suppression and aging. Recent discoveries, however, have extended its known role to include complex biological processes ...
Buch Mundó, Ignasi (Date of defense: 2012-06-29)
Investigation of protein-ligand interactions has been a long-standing application for molecular dynamics (MD) simulations given its importance to drug design. However, relevant timescales for biomolecular motions are orders ...
Ugarte Ruiz, Alfonso (Date of defense: 2011-03-21)
This thesis studies how firms’ investment and credit are affected by different financial imperfections related to firm and bank learning, relationship lending and financial wealth. After reviewing in chapter 2 the related ...
Kummer, Sami (Date of defense: 2020-09-29)
El tabaquismo es la principal causa de muerte evitable en todo el mundo, responsable de más de 7 millones de muertes al año. La nicotina es el principal componente psicoactivo del tabaco y la responsable de sus propiedades ...
La Porta, Carmen (Date of defense: 2015-10-15)
Chronic pain is a major clinical problem producing huge economic and social burdens. Currently, chronic pain treatment has limited efficacy and significant side effects. One of the reasons of this unmet clinical need is ...
Mancino, Samantha (Date of defense: 2016-01-22)
The increase incidence of obesity and eating disorders represents a major health problem in developed countries. The low rate of success of treatments to prevent or reverse obesity, and overeating that causes it, highlights ...
Plaza-Zabala, Ainhoa (Date of defense: 2012-11-26)
Hypocretin-1 and hypocretin-2, also known as orexin-A and orexin-B, are 2 neuropeptides that are exclusively expressed by a small subset of neurons of the lateral hypothalamic area. Despite their restricted expression ...
Calvé Pérez, Pablo (Date of defense: 2022-07-04)
Food addiction is closely associated with eating disorders including obesity and binge eating. However, the neural alterations underlying this disorder have not been yet clarified. We have trained mice in an operant model ...
Facciolo Furlan, Gabriele (Date of defense: 2011-03-03)
The generation of urban digital elevation models from satellite images using stereo reconstruction techniques poses several challenges due to its precision requirements. In this thesis we study three problems related ...
Debroux, Tatsuro (Date of defense: 2018-07-02)
The thesis shows the result of the research on foreign policy during the first and second Abe administration. It focuses on the relations with the US, China, India, Australia, the Philippines, the New Komei Party and ...
Gómez Díez, María Isabel (Date of defense: 2008-09-26)
El objeto de estudio de esta tesis es la interacción que se produce en las audiencias de solicitud de asilo en Bélgica y los textos escritos que se generan en el procedimiento, principalmente, informes de audiencia y ...