Now showing items 2221-2240 of 3213

    Normas Jurídicas, Aceptación y Justificación. La Noción de Razón para la Acción como Instrumento de Análisis Conceptual 

    Redondo Natella, M. Cristina (Date of defense: 1995-03-06)

    EL TRABAJO CONSISTE EN UNA INVESTIGACION METATEORICA ACERCA DE LAS NOCIONES DE RAZON, RAZON PARA LA ACCION Y RAZONAMIENTO PRACTICO Y SU UTILIZACION EN EL ANALISIS DE TRES PROBLEMAS DE LA TEORIA JURIDICA: LA NORMATIVIDAD ...

    "Nosotros" y "los otros" en el discurso sobre Europa y Asia : un estudio comparativo de los libros de texto de España y Japón 

    Shinabe, Naomi (Date of defense: 2014-02-18)

    Los libros de texto transmiten de manera bastante uniforme un determinado conocimiento e ideología a una generación entera en un determinado ámbito territorial. Esta tesis pretende analizar, desde la perspectiva crítica, ...

    Nosotros, el pueblo: figuraciones de la toma de la calle en la historia del cine 

    Santaolaya Cesteros, Clara (Date of defense: 2021-01-15)

    Este trabajo de investigación se propone realizar un particular recorrido por la historia del cine a través de la figuración de la toma de la calle, es decir, a través del gesto mediante el cual la masa se hace presente y ...

    "Not lost to human sight": indian glimpses of privacy in Zenana photographers, Dayanita Singh, Gauri Gill and Ketaki Sheth 

    Mac Dougall, Lola (Date of defense: 2016-10-24)

    This research looks at the contributions made by some Indian women photographers to the representation of privacy. Indian women photographers have enjoyed a privileged access in their bid to depict privacy, or the quality ...

    Notch activation and downstream targets in embryonic hematopoiesis 

    Guiu Sagarra, Jordi (Date of defense: 2012-11-26)

    La regió de l’aorta-gonada-mesonefros (AGM) és el primer nínxol de les cèl·lules mare hematopoètiques. Està descrit que la via de Notch és necessària per generar artèries i cèl·lules mare hematopoètiques. Les cèl·lules ...

    Notch ligands orchestrate the endothelial to hematopoietic transition during embryonic development in the mouse 

    Ferrando Martorell, Eva (Date of defense: 2015-11-10)

    The activation of Notch1 receptor triggers differential outcomes depending on the upstream activating ligand. This way, Jag1-Notch1 activation promotes endothelial to hematopoietic transition process for the generation of ...

    Notch signalling in intestinal homeostasis and cancer: orchestrator of stemness 

    López Arribillaga, Erika (Date of defense: 2016-06-17)

    Wnt/β-catenin and Notch signalling cooperate in regulating the transcription of various genes specifically in the small intestinal stem and progenitor cell compartments. We characterized Bmi1 functionally in this context ...

    Novel approaches against pancreatic cancer based on adenoviral targeting and tumor ablation preclinical evaluation of antitumor efficacy 

    José Segarra-Martínez, Anabel (Date of defense: 2011-12-13)

    Els tractaments actuals pel càncer de pàncreas presenten un eficàcia limitada de manera que es necessari el desenvolupament de noves teràpies antitumorals. La teràpia gènica pel càncer de pàncreas basada en l’ús d’adenovirus ...

    Novel approaches for generalized planning 

    Lotinac, Damir (Date of defense: 2017-12-14)

    Classical planning is the problem of finding a sequence of actions, from a given initial state to some goal state. While, in generalized planning, a plan is a solution to a set of planning problems, which belong to the ...

    Novel genetic mechanisms in autoinflammatory diseases : Contribution of somatic and germline variation 

    Solís Moruno, Manuel (Date of defense: 2021-09-14)

    Autoinflammatory diseases are caused by an antigen independent hyperactivation of inflammatory pathways. The first genetic defect linked to an autoinflammatory disease was described almost 25 years ago and, since then, the ...

    Novel insights in nicotine addiction : focus on cognitive function 

    Saravia Santos, Rocio (Date of defense: 2019-01-10)

    Cigarette smoking continues to be leading cause of preventable cause of death worldwide. Cognitive modulation by nicotine seems to be a key factor in nicotine addiction. Several studies indicate that initial nicotine intake ...

    Novel mechanisms of transcriptional regulation by the yeast hog 1 mapk 

    Mas Martín, Glòria (Date of defense: 2007-07-20)

    En la levadura S. cerevisiae, un incremento de la osmolaridad extracelular activa la vía de Hog1, lo que produce una compleja respuesta adaptativa. Entre las respuestas adaptativas que Hog1 coordina, está un importante ...

    Novel methods for multiple sequence alignment and evolutionary modeling 

    Mansouri, Leila (Date of defense: 2023-03-27)

    El continuo aumento de los proyectos de producción de datos genómicos a gran escala, como el "Earth BioGenome Project" (Lewin et al., 2018), pone los métodos de análisis de datos bajo una presión sin precedentes. Es necesario ...

    Novel pharmacological and electroceutical approaches for memory improvement in animal models of intellectual disability 

    Vázquez Oliver, Anna (Date of defense: 2022-02-18)

    Intellectual disability is a term used to describe a group of neurodevelopmental disorders defined by deficits in cognitive and adaptive functioning with onset during the developmental period. Preclinical research suggest ...

    Novel tools in drug discovery : optimising the use of zebrafish for assessing drug safety and antitumoral efficacy 

    Cornet Bartolomé, Carles (Date of defense: 2020-01-17)

    High drug attrition rate during clinical and post market phases is one of the major factors contributing to the pharmaceutical industry productivity crisis. This problem is especially worrisome in the cancer field, where ...

    Novel transcription regulators of tissue macrophages and alternative macrophage polarization 

    Higuera González, Laura (Date of defense: 2021-10-01)

    Macrophages play crucial roles in the defense of the organism against a wide range of pathogens. Macrophages can rapidly adapt to perturbations in the microenvironment due to the existence of a network of transcription ...

    De novo heterochromatin establishment in 2C-like cells and early embryonic development 

    Sebastián Perez, Rubén (Date of defense: 2021-09-10)

    Chromocenters are established after the 2-cell (2C) stage during mouse embryonic development, but the factors that mediate chromocenter formation remain largely unknown. To identify regulators of 2C heterochromatin ...

    Nuclear and non-nuclear roles of the MAP kinase Sty1 on cell cycle, cell polarity and transcription 

    Salat Canela, Clàudia (Date of defense: 2020-09-30)

    Living organisms must respond to changes in their environment in order to overcome stress situations. In Schizosaccharomyces pombe, Sty1 MAP kinase is required to survive to a wide range of environmental stresses. The main ...

    Nuclear DYRK1A :new insights into its role within the nucleus 

    Di Vona, Chiara (Date of defense: 2013-09-20)

    The view on how protein kinases regulate gene expression have recently expanded to include not only transcription factors but also histones, chromatin remodelers or components of the basal transcription machinery, which ...

    Nucleosome dynamics and analysis in breast cancer cells 

    Pohl, Andy (Date of defense: 2014-10-03)

    Genome-wide analysis of the nucleosome positioning and histone H1 isoform content of the T47D breast cancer cell line has found a number of observations, namely that with a gentle digestion of microccocal nuclease (MNase), ...