Àrea de contingut
Universitat Pompeu Fabra
Browsing Universitat Pompeu Fabra by Subject "578"
Now showing items 1-20 of 25
Anàlisi estructural de partícules i proteïnes del virus de la bursitis infecciosa
La malaltia de la bursitis infecciosa, o alaltia de Gumboro, és una patologia aviària d'origen viral que afecta principalment les cries d'aus. En les granges de cria d'aviram, el virus que la origina, l'IBDV, provoca una ...
Arbovirus Persistence In Mosquitoes: The Role Of Translation Control
Mosquito-transmitted viruses infect both vertebrate hosts, where they cause acute disease, and mosquito vectors, where they establish persistent infection. While persistence in mosquito cells is essential for transmission, ...
Asociación entre la infección por el VIH y el Virus del Papiloma Humano: Implicaciones para la prevención del cáncer de cérvix en mujeres VIH positivas
Antecedentes: La infección por el virus del papiloma humano de alto riesgo HPV (HR) es un factor necesario para las lesiones cervicales (SIL) y el cáncer cervical invasivo (ICC). En las mujeres infectadas por el HIV, la ...
Broad-spectrum host-acting antivirals: identification and characterization of anti-HIV drugs
Hundreds of host factors related to viral infections like HIV, hepatitis C virus, dengue virus or West Nile virus have been identified. As many of these host factors are shared by different viruses, chemical blockade of ...
CD4 and CD8 T-cell activation reflect different pathogenic asprects in chronic HIV-treated subjects
La infecció pel virus de la immunodeficiència humana (VIH) provoca una deficiència progressiva del sistema immunològic, caracteritzada per una destrucció massiva de les cèl•lules T CD4 i, una activació i inflamació immune ...
Characterization of UL1, a member of the human cytomegalovirus RL11 gene family
In the present study, we have approached the molecular characterization of the HCMV specific UL1. To this end a HCMV (AD169-derived HB5 background) recombinant with an HA-epitope tagged UL1 and a mutant with a full UL1 ...
Comparative genomics to unravel virulence mechanisms in fungal human pathogens
Las Candidas forman uno de los grupos con mayor n´umero de hongos pat´ogenos en humanos. La relaci ´on que tienen desde un punto de vista filogen´etico demuestra que la capacidad de infectar humanos ha surgido varias ...
Design and implementation of a next-generation sequencing test for the fast and cost-effective SARS-CoV-2 differantial diagnosis and variant detection
In the beginning of 2020 the WHO declared a pandemic that was initiated by the outbreak of a new virus named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that quickly spread globally, challenging our ...
Identification of HIV-1 reactivating quinoline compounds as bromodomain inhibitors
Tras la infección por VIH-1, el establecimiento de un depósito de células T en reposo infectadas latentemente con VIH impide la erradicación del virus en pacientes. Para lograr la erradicación, la terapia retroviral existente ...
Immunotherapeutic strategies for HIV cure: advancements in the characterisation and development of novel immune checkpoints therapeutics for combinatorial HIV1 immune interventions
Human Immunodeficiency Virus Type 1 (HIV-1) remains a global pandemic requiring the development of curative strategies due to the limitations of current antiretroviral treatments (ART). This thesis focuses on the need for ...
Immunotherapy of chronic virus infections : Exhausted CD8+ T cell subsets are differentially regulated by XCR1 + DC
The contribution of cross-presenting XCR1+ dendritic cells (DC) in maintaining T cell function during exhaustion and immuno-therapeutic interventions of chronic infections remains poorly characterized. Using the mouse model ...
Influence of the NKG2C genotype in the development of adaptive NK cells and characterization of the antibody-mediated response to Epstein-Barr virus
El citomegalovirus humano (HCMV) promueve una redistribución del compartimento de células Natural Killer (NK) marcada por un incremento de las células NK maduras que expresan niveles elevados del receptor activador CD94/NKG2C. ...
Influencia de la cromatina en el lugar de integración sobre la actividad del promotor del virus de la immunodeficiencia humana y el establecimiento de la latencia viral
El establecimiento de un reservorio latente del virus del HIV en células T CD4+ es la mayor barrera contra la erradicación de esta enfermedad. Para lograr su erradicación, se necesitaría combinar la terapia antirretroviral ...
Interplay between cancer cells, fibroblasts, immune cells, and resistance to PD-1/PD-L1 inhibition in breast cancer
Although the dual anti-HER2 blockade with trastuzumab and pertuzumab monoclonal antibodies has improved the outcome of patients with HER2+ breast cancer, a significant number of patients relapse. Additional strategies for ...
Linking cell dynamics with coexpression networks to characterize key events in chronic virus infection
The host immune response against infection requires the coordinated action of many diverse cell subsets that dynamically adapt to a pathogen threat. Due to the complexity of such a response, most immunological studies have ...
Multi-epitope peptide platforms for vaccine applications
Vaccination constitutes one of the most efficient and cost-effective methods of promoting global health. Nevertheless, few vaccines are fully effective, for manifold reasons ranging from intrinsic limitations to more ...
PD-L1 blockade : impact on regulatory T cells from HIV-infected individuals
Bloquejar la via PD-1/PD-L1 ha sorgit com una estratègia prometedora per a restaurar la resposta immune efectora en individus infectats amb el virus de la immunodeficiència humana (VIH). Malgrat l’extensa recerca duta a ...
Prior vaccination maintains lymphatic structure organisation and avoids post-acute virus infection sequelae
La síndrome de Post-infecció aguda (PAIS) és un fenomen poc estudiat que es produeix després d’una infecció viral aguda. Malgrat que la infecció inicial es resol en poques setmanes, poden aparèixer símptomes persistents o ...
Role of the cellular decapping activator LSM1-7 complex in the replication of positive-strand RNA viruses
By using the ability of the positive-strand RNA ((+)RNA) virus BMV to replicate in yeast it was previously shown that subunits of the LSm1-7 ring, as well as Pat1 and Dhh1 play an essential role in the transit of the BMV ...
