Schroeder, Michael Philipp (Date of defense: 2014-11-21)
Cancer is a complex disease caused by somatic alterations of the genome and epigenome in tumor cells. Increased investments and cheaper access to various technologies have built momentum for the generation ...
Singh, Babita (Date of defense: 2017-05-11)
RNA processing and their alterations are determinant to understand normal and disease cell phenotypes. In particular, specific alterations in the RNA processing of genes has been linked to widely accepted ...
Inglés Ferrándiz, Marta (Date of defense: 2018-12-14)
In this thesis, we have been studying the role of UNR, and RNA-binding protein that regulates translation and/or stability of its targets. The functional relevance of UNR was studied in two different ...
Mina Ibarra, Leonardo Bruno (Date of defense: 2010-05-21)
The group of positive strand RNA ((+)RNA) viruses includes numerous plant, animal and human pathogens such as the hepatitis C virus (HCV). Their viral genomes mimic cellular mRNAs, however, besides ...
Bosch de Basea i Gómez, Magda (Date of defense: 2016-11-28)
The present thesis introduces the EPI-CT cohort study; a European collaborative effort aimed at quantifying the health risks of computed tomography (CT scan) radiation exposure during childhood and ...
Sala Romanyà, Laura (Date of defense: 2018-06-20)
Snail1 is a transcription factor which activity is required for the fibroblasts-to-myofibroblast differentiation. In the first part of the thesis we characterize a protein complex involving Snail1, PRMT1 ...
Rubio Pérez, Carlota (Date of defense: 2017-11-28)
Cancer is a disease of the genome. The study of tumor genomic alterations is used to guide several precision medicine strategies, some approved and a large number under clinical development. On the other ...
Güney, Emre (Date of defense: 2012-09-25)
The cell is governed by the complex interactions among various types of biomolecules. Coupled with environmental factors, variations in DNA can cause alterations in normal gene function and lead to a ...
Pavlovic, Milica (Date of defense: 2014-03-11)
El objetivo de esta tesis era identificar determinantes genéticos de cáncer de mama con metástasis óseas. Para ello se utilizó un enfoque integral que se sustenta en células humanas de cáncer de mama, ...
Núñez Ollé, Marc (Date of defense: 2014-07-04)
Cyclin O, a novel identified CDK1 and CDK2-binding cyclin, has been demonstrated to be required for γ-radiation induced apoptosis in a lymphoid cell line. Ɣ-radiation induces the formation of DSBs in ...