Mostrando ítems 11-20 de 295
Ullrich, Sebastian (Fecha de defensa: 2018-12-19)
Gene regulation orchestrates the development of different cell types and organs from the same genetic blueprint. While the basic mode of gene regulation is driven by transcription factors, there are a ...
Demidov, German (Fecha de defensa: 2019-12-13)
Germline copy-number variants (CNVs), as well as somatic copy-number alterations (CNAs), play an important role in many phenotypic traits, including genetic diseases and cancer. Next Generation Sequencing ...
Mendizábal Eceizabarrena, Isabel (Fecha de defensa: 2012-07-27)
The human colonization of worldwide landmasses occurred through complex patterns of dispersal and admixture. At the same time, the survival in the different areas of the world depended on the adaptation ...
Ylla Bou, Guillem (Fecha de defensa: 2018-01-24)
The evolutionary success of insects was particularly shaped by the innovation of the metamorphosis, especially by the transition from hemimetaboly to holometaboly. The mechanisms underlying this ...
Vicencio, Jeremy (Fecha de defensa: 2021-09-03)
In this thesis, I present an alternative, cloning-free method for the generation of endogenous fluorescent reporters in the nematode Caenorhabditis elegans. I demonstrate that Nested CRISPR is an efficient ...
Laurie, Steven (Fecha de defensa: 2013-07-25)
This thesis comprises comparative genomics analyses primarily focussing on the evolution of mammalian proteins. We concentrate on three species of direct relevance as model organisms, for which high ...
Espeso Gil, Sergio (Fecha de defensa: 2016-12-05)
El reguloma està constituït per un sistema complex de factors que controlen el fenotip molecular de la cèl·lula, que al seu torn està influenciada pel medi ambient. Qualsevol pertorbació pot desencadenar ...
Corrionero Saiz, Ana (Fecha de defensa: 2010-12-16)
Alternative splicing provides the cell the ability to generate, from a single gene, multiple protein isoforms, sometimes with different or even antagonistic functions. This process is tightly regulated ...
Carreté Muñoz, Laia (Fecha de defensa: 2018-01-23)
Infections caused by pathogenic fungi are becoming an increasingly serious threat for human health. Pathogenic fungi such as Candida glabrata or Candida albicans, belong to phylogenetically distinct ...
Belloc Rocasalbas, Eulàlia (Fecha de defensa: 2008-12-15)
Els oòcits de vertebrats es troben aturats a la profase I de la primera meiosi (PI). Durant el procés anomenat oogènesi, els oòctits sintetitzen i emmagatzemen grans quantitats d'ARN missatgers(ARNm)que ...