Roewenstrunk, Julia Maria (Date of defense: 2016-12-19)
Gene dosage alterations of the kinase DYRK1A are linked to disease in humans. To better understand DYRK1A activities an interactome analysis was performed. RNF169, an E3-ubiquitin ligase key component ...
Hernández Ribera, Jordi (Date of defense: 2016-11-23)
Alternative pre-mRNA splicing of the Notch regulator NUMB exon 9 switches between isoforms that promote (exon inclusion) or prevent (exon skipping) cell proliferation. We have studied NUMB alternative ...
Doerr, Stefan (Date of defense: 2016-09-16)
Molecular dynamics has established itself over the last years as a strong tool for structure-based molecular investigation in biology. Stefan Doerr's thesis concerns the application of machine learning ...
Vigevani, Luisa (Date of defense: 2016-11-21)
RNA splicing is the process of removal of introns from pre-mRNAs. It is carried out by the spliceosome, composed of five small nuclear ribonucleoproteins (snRNPs). Several small molecules with antitumor ...
Regot Rodríguez de Mier, Sergi (Date of defense: 2011-07-15)
A fundamental property of living cells is the ability to sense and respond appropriately to changing environmental conditions. In budding yeast (Sacharomyces cerevisiae), changes in extracellular osmotic ...
Ní Chárthaigh, Róisín-Ana (Date of defense: 2020-07-03)
RNA-binding proteins are potent regulators of post-transcriptional gene expression. Among the repertoire of RNAs bound by a particular RNA-binding protein, networks of co-ordinately regulated RNAs, or ...
Kemena, Carsten (Date of defense: 2012-12-12)
Sequence alignment is one of the basic methods to compare biological sequences and the cornerstone of a wide range of different analyses. Due to this privileged position at the beginning of many studies ...
Viéitez Manrique, Cristina (Date of defense: 2014-12-18)
In response to fluctuations in the environment, all living organisms have the ability to sense, respond and adapt to the new conditions. In budding yeast (Saccharomyces cerevisiae) there is a massive ...
Poglayen, Daniel (Date of defense: 2016-01-28)
Cellular behaviour is regulated by a very precise system in which the complex interplay between various types of biomolecules plays a crucial role for the proper functioning of the system itself. Proteins ...
Ashok, Anupama (Date of defense: 2019-01-21)
COPII vesicles of 60-90nm diameter are known to export secretory cargoes from endoplasmic reticulum (ER). However, they cannot be employed to export bulky cargoes like the collagens that can reach up ...