Garcia-Elias Heras, Anna (Date of defense: 2011-06-30)
TRPV4 is a non-selective cation channel with a wide expression and multiple cellular and systemic functions. Described initially as an osmosensor, it can also be activated by temperature and cell swelling. ...
Ivancic, Dimitrie (Date of defense: 2024-04-03)
Methods for genome engineering have enabled construction of synthetic genomes, therapeutically reprogrammed cells, synthetic organs, and modification of human genomes. Design and discovery of genome ...
Morales Pastor, Adrián (Date of defense: 2024-04-11)
G protein-coupled receptors (GPCRs) are central to cellular signaling and pivotal in drug development. This thesis investigates allosteric communication in GPCRs, crucial for their effective modulation ...
Vandelli, Andrea (Date of defense: 2023-04-19)
Ribonucleoprotein condensates such as stress granules (SGs) and processing bodies (PBs) form in response to specific stimuli in the cell. Even though the key protein and RNA elements of these condensates ...
Cabús, Lluc (Date of defense: 2024-03-15)
RNA is a molecule that is released by the different tissues into the circulation. When it is found in the circulation it is called cell-free RNA (cfRNA). This type of molecule has great potential as ...
Kennedy, Keith Endres (Date of defense: 2023-05-30)
This thesis focuses on the multiscale nature of the biological process that underpin the function of all living systems. A first project centers on the disease known as multiple sclerosis, and utilizes ...
Galera Laporta, Letícia (Date of defense: 2019-02-08)
Bacterial proliferation has been studied for more than 100 years, but our knowledge of the mechanisms that control its dynamical aspects is still very limited. In this Thesis we have studied, at both ...